Age and Serum AMH and FSH Levels as Predictors of the Number of Oocytes Retrieved from Chromosomal Translocation Carriers after Controlled Ovarian Hyperstimulation: Applicability and Limitations
We studied the impact of age and the serum anti-Müllerian hormone (AMH)/follicle-stimulating hormone (FSH) levels on the number of cumulus-oocyte complexes (COCs) retrieved from female reciprocal and Robertsonian translocation carriers after controlled ovarian hyperstimulation (COH). The number of C...
Gespeichert in:
| Veröffentlicht in: | Genes 2020-12, Vol.12 (1), p.18 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 1 |
| container_start_page | 18 |
| container_title | Genes |
| container_volume | 12 |
| creator | Shilenkova, Yulia V Pendina, Anna A Mekina, Irina D Efimova, Olga A Komarova, Evgeniia M Lesik, Elena A Ishchuk, Mariia A Fedorova, Elena M Chiryaeva, Olga G Petrova, Lubov' I Dudkina, Vera S Talantova, Olga E Gzgzyan, Alexander M Kogan, Igor Yu |
| description | We studied the impact of age and the serum anti-Müllerian hormone (AMH)/follicle-stimulating hormone (FSH) levels on the number of cumulus-oocyte complexes (COCs) retrieved from female reciprocal and Robertsonian translocation carriers after controlled ovarian hyperstimulation (COH). The number of COCs retrieved after COH was retrospectively analyzed in female translocation carriers and 46,XX partners of male translocation carriers from 100 couples. The median number of COCs varied from nine to 16 and did not differ among subgroups of women categorized by age, presence and type of a translocation. The number of COCs correlated negatively with the woman's age in both the reciprocal and the Robertsonian translocation carriers, while in 46,XX women no correlation was detected. The number of COCs did not differ between the reciprocal and the Robertsonian translocation carriers aged either |
| doi_str_mv | 10.3390/genes12010018 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7824090</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2473905027</sourcerecordid><originalsourceid>FETCH-LOGICAL-c387t-eec1f156a7cff716744820e07a3662401a1b13f4792ccef12cad480c07dde3b43</originalsourceid><addsrcrecordid>eNpVUctu1DAUjRCIVqVLtshLNgG_Ms6wQBpFLYM0MIiWdXTjXM8YOXGwnZHm9_gy3GmpWi_se3UePtIpireMfhBiST_ucMTIOGWUsvpFcc6pEqWUvHr5ZD4rLmP8TfORlFNavS7OhBCqquTyvPi72iGBsSc3GOaBrL6tT9v1zZps8IAuEojkR8De6uRDJN6QtEfyfR46DHfb1utjwkh-Ygo2K3pigh9Is8-3j34AR24DjNF5Dcn6kTQQMjFbgUnZovFjCt65LNweIFgYyfo4ZTzZYXYnySeymiZnNXTW2XQ8BdzYwaYTGt8Urwy4iJcP70Xx6_rqtlmXm-2Xr81qU2pRq1QiamZYtQCljVFsoaSsOUWqQCwWXFIGrGPCSLXkWqNhXEMva6qp6nsUnRQXxed732nuBuw15uDg2inYAcKx9WDb58ho9-3OH1pVZ_slzQbvHwyC_zNjTO1go0bnYEQ_x5ZLlUutKFeZWt5TdfAxBjSP3zDa3lXfPqs-8989zfbI_l-0-AdI5K-I</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2473905027</pqid></control><display><type>article</type><title>Age and Serum AMH and FSH Levels as Predictors of the Number of Oocytes Retrieved from Chromosomal Translocation Carriers after Controlled Ovarian Hyperstimulation: Applicability and Limitations</title><source>PubMed Central Open Access</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Shilenkova, Yulia V ; Pendina, Anna A ; Mekina, Irina D ; Efimova, Olga A ; Komarova, Evgeniia M ; Lesik, Elena A ; Ishchuk, Mariia A ; Fedorova, Elena M ; Chiryaeva, Olga G ; Petrova, Lubov' I ; Dudkina, Vera S ; Talantova, Olga E ; Gzgzyan, Alexander M ; Kogan, Igor Yu</creator><creatorcontrib>Shilenkova, Yulia V ; Pendina, Anna A ; Mekina, Irina D ; Efimova, Olga A ; Komarova, Evgeniia M ; Lesik, Elena A ; Ishchuk, Mariia A ; Fedorova, Elena M ; Chiryaeva, Olga G ; Petrova, Lubov' I ; Dudkina, Vera S ; Talantova, Olga E ; Gzgzyan, Alexander M ; Kogan, Igor Yu</creatorcontrib><description>We studied the impact of age and the serum anti-Müllerian hormone (AMH)/follicle-stimulating hormone (FSH) levels on the number of cumulus-oocyte complexes (COCs) retrieved from female reciprocal and Robertsonian translocation carriers after controlled ovarian hyperstimulation (COH). The number of COCs retrieved after COH was retrospectively analyzed in female translocation carriers and 46,XX partners of male translocation carriers from 100 couples. The median number of COCs varied from nine to 16 and did not differ among subgroups of women categorized by age, presence and type of a translocation. The number of COCs correlated negatively with the woman's age in both the reciprocal and the Robertsonian translocation carriers, while in 46,XX women no correlation was detected. The number of COCs did not differ between the reciprocal and the Robertsonian translocation carriers aged either <35 or ≥35 years. In translocation carriers, the number of COCs correlated with the serum AMH level only in the younger-age subgroups; the correlation was strong positive in reciprocal and moderate positive in Robertsonian translocation carriers. The 46,XX women aged both <35 and ≥35 years showed similar moderate positive correlations. Across all subgroups, the number of COCs correlated moderately negatively with the serum FSH level only in Robertsonian translocation carriers aged <35 years. Our results suggest that chromosomal translocations per se do not increase the risk of poor oocyte retrieval outcome after COH. In translocation carriers, oocyte retrieval outcome depends to a large extent on their age. The serum AMH level strongly predicts oocyte retrieval outcomes only in young reciprocal translocation carriers, while the serum FSH level has a moderate predictive value in young Robertsonian translocation carriers.</description><identifier>ISSN: 2073-4425</identifier><identifier>EISSN: 2073-4425</identifier><identifier>DOI: 10.3390/genes12010018</identifier><identifier>PMID: 33375549</identifier><language>eng</language><publisher>Switzerland: MDPI</publisher><ispartof>Genes, 2020-12, Vol.12 (1), p.18</ispartof><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-eec1f156a7cff716744820e07a3662401a1b13f4792ccef12cad480c07dde3b43</citedby><cites>FETCH-LOGICAL-c387t-eec1f156a7cff716744820e07a3662401a1b13f4792ccef12cad480c07dde3b43</cites><orcidid>0000-0003-4495-0983 ; 0000-0003-4992-9905 ; 0000-0002-4443-4287</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824090/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824090/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33375549$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shilenkova, Yulia V</creatorcontrib><creatorcontrib>Pendina, Anna A</creatorcontrib><creatorcontrib>Mekina, Irina D</creatorcontrib><creatorcontrib>Efimova, Olga A</creatorcontrib><creatorcontrib>Komarova, Evgeniia M</creatorcontrib><creatorcontrib>Lesik, Elena A</creatorcontrib><creatorcontrib>Ishchuk, Mariia A</creatorcontrib><creatorcontrib>Fedorova, Elena M</creatorcontrib><creatorcontrib>Chiryaeva, Olga G</creatorcontrib><creatorcontrib>Petrova, Lubov' I</creatorcontrib><creatorcontrib>Dudkina, Vera S</creatorcontrib><creatorcontrib>Talantova, Olga E</creatorcontrib><creatorcontrib>Gzgzyan, Alexander M</creatorcontrib><creatorcontrib>Kogan, Igor Yu</creatorcontrib><title>Age and Serum AMH and FSH Levels as Predictors of the Number of Oocytes Retrieved from Chromosomal Translocation Carriers after Controlled Ovarian Hyperstimulation: Applicability and Limitations</title><title>Genes</title><addtitle>Genes (Basel)</addtitle><description>We studied the impact of age and the serum anti-Müllerian hormone (AMH)/follicle-stimulating hormone (FSH) levels on the number of cumulus-oocyte complexes (COCs) retrieved from female reciprocal and Robertsonian translocation carriers after controlled ovarian hyperstimulation (COH). The number of COCs retrieved after COH was retrospectively analyzed in female translocation carriers and 46,XX partners of male translocation carriers from 100 couples. The median number of COCs varied from nine to 16 and did not differ among subgroups of women categorized by age, presence and type of a translocation. The number of COCs correlated negatively with the woman's age in both the reciprocal and the Robertsonian translocation carriers, while in 46,XX women no correlation was detected. The number of COCs did not differ between the reciprocal and the Robertsonian translocation carriers aged either <35 or ≥35 years. In translocation carriers, the number of COCs correlated with the serum AMH level only in the younger-age subgroups; the correlation was strong positive in reciprocal and moderate positive in Robertsonian translocation carriers. The 46,XX women aged both <35 and ≥35 years showed similar moderate positive correlations. Across all subgroups, the number of COCs correlated moderately negatively with the serum FSH level only in Robertsonian translocation carriers aged <35 years. Our results suggest that chromosomal translocations per se do not increase the risk of poor oocyte retrieval outcome after COH. In translocation carriers, oocyte retrieval outcome depends to a large extent on their age. The serum AMH level strongly predicts oocyte retrieval outcomes only in young reciprocal translocation carriers, while the serum FSH level has a moderate predictive value in young Robertsonian translocation carriers.</description><issn>2073-4425</issn><issn>2073-4425</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNpVUctu1DAUjRCIVqVLtshLNgG_Ms6wQBpFLYM0MIiWdXTjXM8YOXGwnZHm9_gy3GmpWi_se3UePtIpireMfhBiST_ucMTIOGWUsvpFcc6pEqWUvHr5ZD4rLmP8TfORlFNavS7OhBCqquTyvPi72iGBsSc3GOaBrL6tT9v1zZps8IAuEojkR8De6uRDJN6QtEfyfR46DHfb1utjwkh-Ygo2K3pigh9Is8-3j34AR24DjNF5Dcn6kTQQMjFbgUnZovFjCt65LNweIFgYyfo4ZTzZYXYnySeymiZnNXTW2XQ8BdzYwaYTGt8Urwy4iJcP70Xx6_rqtlmXm-2Xr81qU2pRq1QiamZYtQCljVFsoaSsOUWqQCwWXFIGrGPCSLXkWqNhXEMva6qp6nsUnRQXxed732nuBuw15uDg2inYAcKx9WDb58ho9-3OH1pVZ_slzQbvHwyC_zNjTO1go0bnYEQ_x5ZLlUutKFeZWt5TdfAxBjSP3zDa3lXfPqs-8989zfbI_l-0-AdI5K-I</recordid><startdate>20201225</startdate><enddate>20201225</enddate><creator>Shilenkova, Yulia V</creator><creator>Pendina, Anna A</creator><creator>Mekina, Irina D</creator><creator>Efimova, Olga A</creator><creator>Komarova, Evgeniia M</creator><creator>Lesik, Elena A</creator><creator>Ishchuk, Mariia A</creator><creator>Fedorova, Elena M</creator><creator>Chiryaeva, Olga G</creator><creator>Petrova, Lubov' I</creator><creator>Dudkina, Vera S</creator><creator>Talantova, Olga E</creator><creator>Gzgzyan, Alexander M</creator><creator>Kogan, Igor Yu</creator><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4495-0983</orcidid><orcidid>https://orcid.org/0000-0003-4992-9905</orcidid><orcidid>https://orcid.org/0000-0002-4443-4287</orcidid></search><sort><creationdate>20201225</creationdate><title>Age and Serum AMH and FSH Levels as Predictors of the Number of Oocytes Retrieved from Chromosomal Translocation Carriers after Controlled Ovarian Hyperstimulation: Applicability and Limitations</title><author>Shilenkova, Yulia V ; Pendina, Anna A ; Mekina, Irina D ; Efimova, Olga A ; Komarova, Evgeniia M ; Lesik, Elena A ; Ishchuk, Mariia A ; Fedorova, Elena M ; Chiryaeva, Olga G ; Petrova, Lubov' I ; Dudkina, Vera S ; Talantova, Olga E ; Gzgzyan, Alexander M ; Kogan, Igor Yu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-eec1f156a7cff716744820e07a3662401a1b13f4792ccef12cad480c07dde3b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shilenkova, Yulia V</creatorcontrib><creatorcontrib>Pendina, Anna A</creatorcontrib><creatorcontrib>Mekina, Irina D</creatorcontrib><creatorcontrib>Efimova, Olga A</creatorcontrib><creatorcontrib>Komarova, Evgeniia M</creatorcontrib><creatorcontrib>Lesik, Elena A</creatorcontrib><creatorcontrib>Ishchuk, Mariia A</creatorcontrib><creatorcontrib>Fedorova, Elena M</creatorcontrib><creatorcontrib>Chiryaeva, Olga G</creatorcontrib><creatorcontrib>Petrova, Lubov' I</creatorcontrib><creatorcontrib>Dudkina, Vera S</creatorcontrib><creatorcontrib>Talantova, Olga E</creatorcontrib><creatorcontrib>Gzgzyan, Alexander M</creatorcontrib><creatorcontrib>Kogan, Igor Yu</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Genes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shilenkova, Yulia V</au><au>Pendina, Anna A</au><au>Mekina, Irina D</au><au>Efimova, Olga A</au><au>Komarova, Evgeniia M</au><au>Lesik, Elena A</au><au>Ishchuk, Mariia A</au><au>Fedorova, Elena M</au><au>Chiryaeva, Olga G</au><au>Petrova, Lubov' I</au><au>Dudkina, Vera S</au><au>Talantova, Olga E</au><au>Gzgzyan, Alexander M</au><au>Kogan, Igor Yu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age and Serum AMH and FSH Levels as Predictors of the Number of Oocytes Retrieved from Chromosomal Translocation Carriers after Controlled Ovarian Hyperstimulation: Applicability and Limitations</atitle><jtitle>Genes</jtitle><addtitle>Genes (Basel)</addtitle><date>2020-12-25</date><risdate>2020</risdate><volume>12</volume><issue>1</issue><spage>18</spage><pages>18-</pages><issn>2073-4425</issn><eissn>2073-4425</eissn><abstract>We studied the impact of age and the serum anti-Müllerian hormone (AMH)/follicle-stimulating hormone (FSH) levels on the number of cumulus-oocyte complexes (COCs) retrieved from female reciprocal and Robertsonian translocation carriers after controlled ovarian hyperstimulation (COH). The number of COCs retrieved after COH was retrospectively analyzed in female translocation carriers and 46,XX partners of male translocation carriers from 100 couples. The median number of COCs varied from nine to 16 and did not differ among subgroups of women categorized by age, presence and type of a translocation. The number of COCs correlated negatively with the woman's age in both the reciprocal and the Robertsonian translocation carriers, while in 46,XX women no correlation was detected. The number of COCs did not differ between the reciprocal and the Robertsonian translocation carriers aged either <35 or ≥35 years. In translocation carriers, the number of COCs correlated with the serum AMH level only in the younger-age subgroups; the correlation was strong positive in reciprocal and moderate positive in Robertsonian translocation carriers. The 46,XX women aged both <35 and ≥35 years showed similar moderate positive correlations. Across all subgroups, the number of COCs correlated moderately negatively with the serum FSH level only in Robertsonian translocation carriers aged <35 years. Our results suggest that chromosomal translocations per se do not increase the risk of poor oocyte retrieval outcome after COH. In translocation carriers, oocyte retrieval outcome depends to a large extent on their age. The serum AMH level strongly predicts oocyte retrieval outcomes only in young reciprocal translocation carriers, while the serum FSH level has a moderate predictive value in young Robertsonian translocation carriers.</abstract><cop>Switzerland</cop><pub>MDPI</pub><pmid>33375549</pmid><doi>10.3390/genes12010018</doi><orcidid>https://orcid.org/0000-0003-4495-0983</orcidid><orcidid>https://orcid.org/0000-0003-4992-9905</orcidid><orcidid>https://orcid.org/0000-0002-4443-4287</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2073-4425 |
| ispartof | Genes, 2020-12, Vol.12 (1), p.18 |
| issn | 2073-4425 2073-4425 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7824090 |
| source | PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| title | Age and Serum AMH and FSH Levels as Predictors of the Number of Oocytes Retrieved from Chromosomal Translocation Carriers after Controlled Ovarian Hyperstimulation: Applicability and Limitations |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T08%3A42%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Age%20and%20Serum%20AMH%20and%20FSH%20Levels%20as%20Predictors%20of%20the%20Number%20of%20Oocytes%20Retrieved%20from%20Chromosomal%20Translocation%20Carriers%20after%20Controlled%20Ovarian%20Hyperstimulation:%20Applicability%20and%20Limitations&rft.jtitle=Genes&rft.au=Shilenkova,%20Yulia%20V&rft.date=2020-12-25&rft.volume=12&rft.issue=1&rft.spage=18&rft.pages=18-&rft.issn=2073-4425&rft.eissn=2073-4425&rft_id=info:doi/10.3390/genes12010018&rft_dat=%3Cproquest_pubme%3E2473905027%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2473905027&rft_id=info:pmid/33375549&rfr_iscdi=true |