Biological Regulatory Network (BRN) Analysis and Molecular Docking Simulations to Probe the Modulation of IP3R Mediated Ca2+ Signaling in Cancer

Inositol trisphosphate receptor (IP3R) mediated Ca+2 signaling is essential in determining the cell fate by regulating numerous cellular processes, including cell division and cell death. Despite extensive studies about the characterization of IP3R in cancer, the underlying molecular mechanism initi...

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Veröffentlicht in:	Genes 2020-12, Vol.12 (1), p.34
Hauptverfasser:	Ismatullah, Humaira, Jabeen, Ishrat, Saeed, Muhammad Tariq
Format:	Artikel
Sprache:	eng
Schlagworte:	Antagonists Apoptosis Autophagy Biological activity Boolean Calcium signalling Cancer Cell death Cell division Cell fate Cell growth Cell proliferation Conformation Endoplasmic reticulum Homeostasis Inositol 1,4,5-trisphosphate receptors Kinases Ligands Mitochondria Ordinary differential equations Phosphatase Proteins Simulation Software Tumorigenesis
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