Field Study of the Possible Effect of Parental Irradiation on the Germline of Children Born to Cleanup Workers and Evacuees of the Chornobyl Nuclear Accident
Abstract Although transgenerational effects of exposure to ionizing radiation have long been a concern, human research to date has been confined to studies of disease phenotypes in groups exposed to high doses and high dose rates, such as the Japanese atomic bomb survivors. Transgenerational effects...
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creator | Bazyka, Dimitry Hatch, Maureen Gudzenko, Natalia Cahoon, Elizabeth K Drozdovitch, Vladimir Little, Mark P Chumak, Vadim Bakhanova, Elena Belyi, David Kryuchkov, Victor Golovanov, Ivan Mabuchi, Kiyohiko Illienko, Iryna Belayev, Yuri Bodelon, Clara Machiela, Mitchell J Hutchinson, Amy Yeager, Meredith de Gonzalez, Amy Berrington Chanock, Stephen J |
description | Abstract
Although transgenerational effects of exposure to ionizing radiation have long been a concern, human research to date has been confined to studies of disease phenotypes in groups exposed to high doses and high dose rates, such as the Japanese atomic bomb survivors. Transgenerational effects of parental irradiation can be addressed using powerful new genomic technologies. In collaboration with the Ukrainian National Research Center for Radiation Medicine, the US National Cancer Institute, in 2014–2018, initiated a genomic alterations study among children born in selected regions of Ukraine to cleanup workers and/or evacuees exposed to low–dose-rate radiation after the 1986 Chornobyl (Chernobyl) nuclear accident. To investigate whether parental radiation exposure is associated with germline mutations and genomic alterations in the offspring, we are collecting biospecimens from father-mother-offspring constellations to study de novo mutations, minisatellite mutations, copy-number changes, structural variants, genomic insertions and deletions, methylation profiles, and telomere length. Genomic alterations are being examined in relation to parental gonadal dose, reconstructed using questionnaire and measurement data. Subjects are being recruited in exposure categories that will allow examination of parental origin, duration, and timing of exposure in relation to conception. Here we describe the study methodology and recruitment results and provide descriptive information on the first 150 families (mother-father-child(ren)) enrolled. |
doi_str_mv | 10.1093/aje/kwaa095 |
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Although transgenerational effects of exposure to ionizing radiation have long been a concern, human research to date has been confined to studies of disease phenotypes in groups exposed to high doses and high dose rates, such as the Japanese atomic bomb survivors. Transgenerational effects of parental irradiation can be addressed using powerful new genomic technologies. In collaboration with the Ukrainian National Research Center for Radiation Medicine, the US National Cancer Institute, in 2014–2018, initiated a genomic alterations study among children born in selected regions of Ukraine to cleanup workers and/or evacuees exposed to low–dose-rate radiation after the 1986 Chornobyl (Chernobyl) nuclear accident. To investigate whether parental radiation exposure is associated with germline mutations and genomic alterations in the offspring, we are collecting biospecimens from father-mother-offspring constellations to study de novo mutations, minisatellite mutations, copy-number changes, structural variants, genomic insertions and deletions, methylation profiles, and telomere length. Genomic alterations are being examined in relation to parental gonadal dose, reconstructed using questionnaire and measurement data. Subjects are being recruited in exposure categories that will allow examination of parental origin, duration, and timing of exposure in relation to conception. Here we describe the study methodology and recruitment results and provide descriptive information on the first 150 families (mother-father-child(ren)) enrolled.</description><identifier>ISSN: 0002-9262</identifier><identifier>EISSN: 1476-6256</identifier><identifier>DOI: 10.1093/aje/kwaa095</identifier><identifier>PMID: 32613232</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Adult ; Atomic bombs ; Chernobyl Nuclear Accident ; Children ; Constellations ; Female ; Fission weapons ; Follow-Up Studies ; Genomics ; Germ-Line Mutation ; Humans ; Ionizing radiation ; Irradiation ; Male ; Maternal Exposure - adverse effects ; Methylation ; Mutation ; Nuclear accidents ; Nuclear accidents & safety ; Nuclear medicine ; Nuclear weapons ; Occupational exposure ; Offspring ; Paternal Exposure - adverse effects ; Phenotypes ; Radiation Dosage ; Radiation effects ; Research facilities ; Study Design ; Telomeres ; Young Adult</subject><ispartof>American journal of epidemiology, 2020-12, Vol.189 (12), p.1451-1460</ispartof><rights>Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health 2020. This work is written by (a) US Government employee(s) and is in the public domain in the US. 2020</rights><rights>Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health 2020. This work is written by (a) US Government employee(s) and is in the public domain in the US.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-cd725230f1cb32897b512646bd296e5dff006a58a7b99eb6c39c09559d8643463</citedby><cites>FETCH-LOGICAL-c440t-cd725230f1cb32897b512646bd296e5dff006a58a7b99eb6c39c09559d8643463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,1584,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32613232$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bazyka, Dimitry</creatorcontrib><creatorcontrib>Hatch, Maureen</creatorcontrib><creatorcontrib>Gudzenko, Natalia</creatorcontrib><creatorcontrib>Cahoon, Elizabeth K</creatorcontrib><creatorcontrib>Drozdovitch, Vladimir</creatorcontrib><creatorcontrib>Little, Mark P</creatorcontrib><creatorcontrib>Chumak, Vadim</creatorcontrib><creatorcontrib>Bakhanova, Elena</creatorcontrib><creatorcontrib>Belyi, David</creatorcontrib><creatorcontrib>Kryuchkov, Victor</creatorcontrib><creatorcontrib>Golovanov, Ivan</creatorcontrib><creatorcontrib>Mabuchi, Kiyohiko</creatorcontrib><creatorcontrib>Illienko, Iryna</creatorcontrib><creatorcontrib>Belayev, Yuri</creatorcontrib><creatorcontrib>Bodelon, Clara</creatorcontrib><creatorcontrib>Machiela, Mitchell J</creatorcontrib><creatorcontrib>Hutchinson, Amy</creatorcontrib><creatorcontrib>Yeager, Meredith</creatorcontrib><creatorcontrib>de Gonzalez, Amy Berrington</creatorcontrib><creatorcontrib>Chanock, Stephen J</creatorcontrib><title>Field Study of the Possible Effect of Parental Irradiation on the Germline of Children Born to Cleanup Workers and Evacuees of the Chornobyl Nuclear Accident</title><title>American journal of epidemiology</title><addtitle>Am J Epidemiol</addtitle><description>Abstract
Although transgenerational effects of exposure to ionizing radiation have long been a concern, human research to date has been confined to studies of disease phenotypes in groups exposed to high doses and high dose rates, such as the Japanese atomic bomb survivors. Transgenerational effects of parental irradiation can be addressed using powerful new genomic technologies. In collaboration with the Ukrainian National Research Center for Radiation Medicine, the US National Cancer Institute, in 2014–2018, initiated a genomic alterations study among children born in selected regions of Ukraine to cleanup workers and/or evacuees exposed to low–dose-rate radiation after the 1986 Chornobyl (Chernobyl) nuclear accident. To investigate whether parental radiation exposure is associated with germline mutations and genomic alterations in the offspring, we are collecting biospecimens from father-mother-offspring constellations to study de novo mutations, minisatellite mutations, copy-number changes, structural variants, genomic insertions and deletions, methylation profiles, and telomere length. Genomic alterations are being examined in relation to parental gonadal dose, reconstructed using questionnaire and measurement data. Subjects are being recruited in exposure categories that will allow examination of parental origin, duration, and timing of exposure in relation to conception. Here we describe the study methodology and recruitment results and provide descriptive information on the first 150 families (mother-father-child(ren)) enrolled.</description><subject>Adult</subject><subject>Atomic bombs</subject><subject>Chernobyl Nuclear Accident</subject><subject>Children</subject><subject>Constellations</subject><subject>Female</subject><subject>Fission weapons</subject><subject>Follow-Up Studies</subject><subject>Genomics</subject><subject>Germ-Line Mutation</subject><subject>Humans</subject><subject>Ionizing radiation</subject><subject>Irradiation</subject><subject>Male</subject><subject>Maternal Exposure - adverse effects</subject><subject>Methylation</subject><subject>Mutation</subject><subject>Nuclear accidents</subject><subject>Nuclear accidents & safety</subject><subject>Nuclear medicine</subject><subject>Nuclear weapons</subject><subject>Occupational exposure</subject><subject>Offspring</subject><subject>Paternal Exposure - adverse effects</subject><subject>Phenotypes</subject><subject>Radiation Dosage</subject><subject>Radiation effects</subject><subject>Research facilities</subject><subject>Study Design</subject><subject>Telomeres</subject><subject>Young Adult</subject><issn>0002-9262</issn><issn>1476-6256</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9r3DAQxUVpabZpT70XQSGX4kZ_LHl1KaRmkwZCGkhCjkKWxl1ttNZWthP2w_S7VmY3ob0EBgZmfrw3zEPoIyVfKVH82Kzg-P7RGKLEKzSjZSULyYR8jWaEEFYoJtkBetf3K0IoVYK8RQecScoZZzP059RDcPh6GN0WxxYPS8BXse99EwAv2hbsMI2vTIJuMAGfp2ScN4OPHc414WeQ1sF3MHH10geXUfw9pryNuA5gunGD72K6h9Rj0zm8eDB2BOif_OplhmOzDfhytJlP-MRa77Lhe_SmNaGHD_t-iG5PFzf1j-Li59l5fXJR2LIkQ2FdxQTjpKW24WyuqkZQJkvZOKYkCNe2hEgj5qZqlIJGWq5s_pZQbi5LXkp-iL7tdDdjswZns3UyQW-SX5u01dF4_f-m80v9Kz7oas6yEckCn_cCKf4eoR_0Ko6pyzdrlgOhgjE1UV92lE35xQnaZwdK9JSlzlnqfZaZ_vTvUc_sU3gZONoBcdy8qPQX7kKqHQ</recordid><startdate>20201201</startdate><enddate>20201201</enddate><creator>Bazyka, Dimitry</creator><creator>Hatch, Maureen</creator><creator>Gudzenko, Natalia</creator><creator>Cahoon, Elizabeth K</creator><creator>Drozdovitch, Vladimir</creator><creator>Little, Mark P</creator><creator>Chumak, Vadim</creator><creator>Bakhanova, Elena</creator><creator>Belyi, David</creator><creator>Kryuchkov, Victor</creator><creator>Golovanov, Ivan</creator><creator>Mabuchi, Kiyohiko</creator><creator>Illienko, Iryna</creator><creator>Belayev, Yuri</creator><creator>Bodelon, Clara</creator><creator>Machiela, Mitchell J</creator><creator>Hutchinson, Amy</creator><creator>Yeager, Meredith</creator><creator>de Gonzalez, Amy Berrington</creator><creator>Chanock, Stephen J</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T2</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>5PM</scope></search><sort><creationdate>20201201</creationdate><title>Field Study of the Possible Effect of Parental Irradiation on the Germline of Children Born to Cleanup Workers and Evacuees of the Chornobyl Nuclear Accident</title><author>Bazyka, Dimitry ; Hatch, Maureen ; Gudzenko, Natalia ; Cahoon, Elizabeth K ; Drozdovitch, Vladimir ; Little, Mark P ; Chumak, Vadim ; Bakhanova, Elena ; Belyi, David ; Kryuchkov, Victor ; Golovanov, Ivan ; Mabuchi, Kiyohiko ; Illienko, Iryna ; Belayev, Yuri ; Bodelon, Clara ; Machiela, Mitchell J ; Hutchinson, Amy ; Yeager, Meredith ; de Gonzalez, Amy Berrington ; Chanock, Stephen J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-cd725230f1cb32897b512646bd296e5dff006a58a7b99eb6c39c09559d8643463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Atomic bombs</topic><topic>Chernobyl Nuclear Accident</topic><topic>Children</topic><topic>Constellations</topic><topic>Female</topic><topic>Fission weapons</topic><topic>Follow-Up Studies</topic><topic>Genomics</topic><topic>Germ-Line Mutation</topic><topic>Humans</topic><topic>Ionizing radiation</topic><topic>Irradiation</topic><topic>Male</topic><topic>Maternal Exposure - adverse effects</topic><topic>Methylation</topic><topic>Mutation</topic><topic>Nuclear accidents</topic><topic>Nuclear accidents & safety</topic><topic>Nuclear medicine</topic><topic>Nuclear weapons</topic><topic>Occupational exposure</topic><topic>Offspring</topic><topic>Paternal Exposure - adverse effects</topic><topic>Phenotypes</topic><topic>Radiation Dosage</topic><topic>Radiation effects</topic><topic>Research facilities</topic><topic>Study Design</topic><topic>Telomeres</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bazyka, Dimitry</creatorcontrib><creatorcontrib>Hatch, Maureen</creatorcontrib><creatorcontrib>Gudzenko, Natalia</creatorcontrib><creatorcontrib>Cahoon, Elizabeth K</creatorcontrib><creatorcontrib>Drozdovitch, Vladimir</creatorcontrib><creatorcontrib>Little, Mark P</creatorcontrib><creatorcontrib>Chumak, Vadim</creatorcontrib><creatorcontrib>Bakhanova, Elena</creatorcontrib><creatorcontrib>Belyi, David</creatorcontrib><creatorcontrib>Kryuchkov, Victor</creatorcontrib><creatorcontrib>Golovanov, Ivan</creatorcontrib><creatorcontrib>Mabuchi, Kiyohiko</creatorcontrib><creatorcontrib>Illienko, Iryna</creatorcontrib><creatorcontrib>Belayev, Yuri</creatorcontrib><creatorcontrib>Bodelon, Clara</creatorcontrib><creatorcontrib>Machiela, Mitchell J</creatorcontrib><creatorcontrib>Hutchinson, Amy</creatorcontrib><creatorcontrib>Yeager, Meredith</creatorcontrib><creatorcontrib>de Gonzalez, Amy Berrington</creatorcontrib><creatorcontrib>Chanock, Stephen J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bazyka, Dimitry</au><au>Hatch, Maureen</au><au>Gudzenko, Natalia</au><au>Cahoon, Elizabeth K</au><au>Drozdovitch, Vladimir</au><au>Little, Mark P</au><au>Chumak, Vadim</au><au>Bakhanova, Elena</au><au>Belyi, David</au><au>Kryuchkov, Victor</au><au>Golovanov, Ivan</au><au>Mabuchi, Kiyohiko</au><au>Illienko, Iryna</au><au>Belayev, Yuri</au><au>Bodelon, Clara</au><au>Machiela, Mitchell J</au><au>Hutchinson, Amy</au><au>Yeager, Meredith</au><au>de Gonzalez, Amy Berrington</au><au>Chanock, Stephen J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Field Study of the Possible Effect of Parental Irradiation on the Germline of Children Born to Cleanup Workers and Evacuees of the Chornobyl Nuclear Accident</atitle><jtitle>American journal of epidemiology</jtitle><addtitle>Am J Epidemiol</addtitle><date>2020-12-01</date><risdate>2020</risdate><volume>189</volume><issue>12</issue><spage>1451</spage><epage>1460</epage><pages>1451-1460</pages><issn>0002-9262</issn><eissn>1476-6256</eissn><abstract>Abstract
Although transgenerational effects of exposure to ionizing radiation have long been a concern, human research to date has been confined to studies of disease phenotypes in groups exposed to high doses and high dose rates, such as the Japanese atomic bomb survivors. Transgenerational effects of parental irradiation can be addressed using powerful new genomic technologies. In collaboration with the Ukrainian National Research Center for Radiation Medicine, the US National Cancer Institute, in 2014–2018, initiated a genomic alterations study among children born in selected regions of Ukraine to cleanup workers and/or evacuees exposed to low–dose-rate radiation after the 1986 Chornobyl (Chernobyl) nuclear accident. To investigate whether parental radiation exposure is associated with germline mutations and genomic alterations in the offspring, we are collecting biospecimens from father-mother-offspring constellations to study de novo mutations, minisatellite mutations, copy-number changes, structural variants, genomic insertions and deletions, methylation profiles, and telomere length. Genomic alterations are being examined in relation to parental gonadal dose, reconstructed using questionnaire and measurement data. Subjects are being recruited in exposure categories that will allow examination of parental origin, duration, and timing of exposure in relation to conception. Here we describe the study methodology and recruitment results and provide descriptive information on the first 150 families (mother-father-child(ren)) enrolled.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>32613232</pmid><doi>10.1093/aje/kwaa095</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adult Atomic bombs Chernobyl Nuclear Accident Children Constellations Female Fission weapons Follow-Up Studies Genomics Germ-Line Mutation Humans Ionizing radiation Irradiation Male Maternal Exposure - adverse effects Methylation Mutation Nuclear accidents Nuclear accidents & safety Nuclear medicine Nuclear weapons Occupational exposure Offspring Paternal Exposure - adverse effects Phenotypes Radiation Dosage Radiation effects Research facilities Study Design Telomeres Young Adult |
title | Field Study of the Possible Effect of Parental Irradiation on the Germline of Children Born to Cleanup Workers and Evacuees of the Chornobyl Nuclear Accident |
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