Field Study of the Possible Effect of Parental Irradiation on the Germline of Children Born to Cleanup Workers and Evacuees of the Chornobyl Nuclear Accident

Abstract Although transgenerational effects of exposure to ionizing radiation have long been a concern, human research to date has been confined to studies of disease phenotypes in groups exposed to high doses and high dose rates, such as the Japanese atomic bomb survivors. Transgenerational effects...

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Veröffentlicht in:American journal of epidemiology 2020-12, Vol.189 (12), p.1451-1460
Hauptverfasser: Bazyka, Dimitry, Hatch, Maureen, Gudzenko, Natalia, Cahoon, Elizabeth K, Drozdovitch, Vladimir, Little, Mark P, Chumak, Vadim, Bakhanova, Elena, Belyi, David, Kryuchkov, Victor, Golovanov, Ivan, Mabuchi, Kiyohiko, Illienko, Iryna, Belayev, Yuri, Bodelon, Clara, Machiela, Mitchell J, Hutchinson, Amy, Yeager, Meredith, de Gonzalez, Amy Berrington, Chanock, Stephen J
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container_issue 12
container_start_page 1451
container_title American journal of epidemiology
container_volume 189
creator Bazyka, Dimitry
Hatch, Maureen
Gudzenko, Natalia
Cahoon, Elizabeth K
Drozdovitch, Vladimir
Little, Mark P
Chumak, Vadim
Bakhanova, Elena
Belyi, David
Kryuchkov, Victor
Golovanov, Ivan
Mabuchi, Kiyohiko
Illienko, Iryna
Belayev, Yuri
Bodelon, Clara
Machiela, Mitchell J
Hutchinson, Amy
Yeager, Meredith
de Gonzalez, Amy Berrington
Chanock, Stephen J
description Abstract Although transgenerational effects of exposure to ionizing radiation have long been a concern, human research to date has been confined to studies of disease phenotypes in groups exposed to high doses and high dose rates, such as the Japanese atomic bomb survivors. Transgenerational effects of parental irradiation can be addressed using powerful new genomic technologies. In collaboration with the Ukrainian National Research Center for Radiation Medicine, the US National Cancer Institute, in 2014–2018, initiated a genomic alterations study among children born in selected regions of Ukraine to cleanup workers and/or evacuees exposed to low–dose-rate radiation after the 1986 Chornobyl (Chernobyl) nuclear accident. To investigate whether parental radiation exposure is associated with germline mutations and genomic alterations in the offspring, we are collecting biospecimens from father-mother-offspring constellations to study de novo mutations, minisatellite mutations, copy-number changes, structural variants, genomic insertions and deletions, methylation profiles, and telomere length. Genomic alterations are being examined in relation to parental gonadal dose, reconstructed using questionnaire and measurement data. Subjects are being recruited in exposure categories that will allow examination of parental origin, duration, and timing of exposure in relation to conception. Here we describe the study methodology and recruitment results and provide descriptive information on the first 150 families (mother-father-child(ren)) enrolled.
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subjects Adult
Atomic bombs
Chernobyl Nuclear Accident
Children
Constellations
Female
Fission weapons
Follow-Up Studies
Genomics
Germ-Line Mutation
Humans
Ionizing radiation
Irradiation
Male
Maternal Exposure - adverse effects
Methylation
Mutation
Nuclear accidents
Nuclear accidents & safety
Nuclear medicine
Nuclear weapons
Occupational exposure
Offspring
Paternal Exposure - adverse effects
Phenotypes
Radiation Dosage
Radiation effects
Research facilities
Study Design
Telomeres
Young Adult
title Field Study of the Possible Effect of Parental Irradiation on the Germline of Children Born to Cleanup Workers and Evacuees of the Chornobyl Nuclear Accident
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