Making translation work: Harmonizing cross-species methodology in the behavioural neuroscience of Pavlovian fear conditioning
•Considers methodological comparability of translational research in fear conditioning in rodents and humans.•Equips researchers with practical and methodological considerations across species to foster translational behavioural neuroscience.•Aid designing of future experiments that employ more comp...
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| Veröffentlicht in: | Neuroscience and biobehavioral reviews 2019-12, Vol.107, p.329-345 |
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| creator | Haaker, Jan Maren, Stephen Andreatta, Marta Merz, Christian J. Richter, Jan Richter, S. Helene Meir Drexler, Shira Lange, Maren D. Jüngling, Kay Nees, Frauke Seidenbecher, Thomas Fullana, Miquel A. Wotjak, Carsten T. Lonsdorf, Tina B. |
| description | •Considers methodological comparability of translational research in fear conditioning in rodents and humans.•Equips researchers with practical and methodological considerations across species to foster translational behavioural neuroscience.•Aid designing of future experiments that employ more comparable processes in human participants and laboratory rodents in fear conditioning protocols.•Originates from discussions about fear conditioning protocols used in rodents and humans.
Translational neuroscience bridges insights from specific mechanisms in rodents to complex functions in humans and is key to advance our general understanding of central nervous function. A prime example of translational research is the study of cross-species mechanisms that underlie responding to learned threats, by employing Pavlovian fear conditioning protocols in rodents and humans. Hitherto, evidence for (and critique of) these cross-species comparisons in fear conditioning research was based on theoretical viewpoints. Here, we provide a perspective to substantiate these theoretical concepts with empirical considerations of cross-species methodology. This meta-research perspective is expected to foster cross-species comparability and reproducibility to ultimately facilitate successful transfer of results from basic science into clinical applications. |
| doi_str_mv | 10.1016/j.neubiorev.2019.09.020 |
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Translational neuroscience bridges insights from specific mechanisms in rodents to complex functions in humans and is key to advance our general understanding of central nervous function. A prime example of translational research is the study of cross-species mechanisms that underlie responding to learned threats, by employing Pavlovian fear conditioning protocols in rodents and humans. Hitherto, evidence for (and critique of) these cross-species comparisons in fear conditioning research was based on theoretical viewpoints. Here, we provide a perspective to substantiate these theoretical concepts with empirical considerations of cross-species methodology. This meta-research perspective is expected to foster cross-species comparability and reproducibility to ultimately facilitate successful transfer of results from basic science into clinical applications.</description><identifier>ISSN: 0149-7634</identifier><identifier>ISSN: 1873-7528</identifier><identifier>EISSN: 1873-7528</identifier><identifier>DOI: 10.1016/j.neubiorev.2019.09.020</identifier><identifier>PMID: 31521698</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Associative learning ; Conditioning, Classical - physiology ; Extinction, Psychological - physiology ; Fear - physiology ; Fear conditioning ; Fear extinction ; FPS ; Heat-rate ; Human ; Humans ; Individual differences ; Meta-research ; Methods ; Neurosciences ; Paradigm ; Reflex, Startle - physiology ; Rodent ; SCR ; Startle ; Translation ; Translational Research, Biomedical - methods ; Treezing</subject><ispartof>Neuroscience and biobehavioral reviews, 2019-12, Vol.107, p.329-345</ispartof><rights>2019 The Authors</rights><rights>Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-521eed576875281582d4c2b736e5849e8ff0a307c45c3d840112bc41b804a2df3</citedby><cites>FETCH-LOGICAL-c475t-521eed576875281582d4c2b736e5849e8ff0a307c45c3d840112bc41b804a2df3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S014976341930288X$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31521698$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Haaker, Jan</creatorcontrib><creatorcontrib>Maren, Stephen</creatorcontrib><creatorcontrib>Andreatta, Marta</creatorcontrib><creatorcontrib>Merz, Christian J.</creatorcontrib><creatorcontrib>Richter, Jan</creatorcontrib><creatorcontrib>Richter, S. Helene</creatorcontrib><creatorcontrib>Meir Drexler, Shira</creatorcontrib><creatorcontrib>Lange, Maren D.</creatorcontrib><creatorcontrib>Jüngling, Kay</creatorcontrib><creatorcontrib>Nees, Frauke</creatorcontrib><creatorcontrib>Seidenbecher, Thomas</creatorcontrib><creatorcontrib>Fullana, Miquel A.</creatorcontrib><creatorcontrib>Wotjak, Carsten T.</creatorcontrib><creatorcontrib>Lonsdorf, Tina B.</creatorcontrib><title>Making translation work: Harmonizing cross-species methodology in the behavioural neuroscience of Pavlovian fear conditioning</title><title>Neuroscience and biobehavioral reviews</title><addtitle>Neurosci Biobehav Rev</addtitle><description>•Considers methodological comparability of translational research in fear conditioning in rodents and humans.•Equips researchers with practical and methodological considerations across species to foster translational behavioural neuroscience.•Aid designing of future experiments that employ more comparable processes in human participants and laboratory rodents in fear conditioning protocols.•Originates from discussions about fear conditioning protocols used in rodents and humans.
Translational neuroscience bridges insights from specific mechanisms in rodents to complex functions in humans and is key to advance our general understanding of central nervous function. A prime example of translational research is the study of cross-species mechanisms that underlie responding to learned threats, by employing Pavlovian fear conditioning protocols in rodents and humans. Hitherto, evidence for (and critique of) these cross-species comparisons in fear conditioning research was based on theoretical viewpoints. Here, we provide a perspective to substantiate these theoretical concepts with empirical considerations of cross-species methodology. This meta-research perspective is expected to foster cross-species comparability and reproducibility to ultimately facilitate successful transfer of results from basic science into clinical applications.</description><subject>Associative learning</subject><subject>Conditioning, Classical - physiology</subject><subject>Extinction, Psychological - physiology</subject><subject>Fear - physiology</subject><subject>Fear conditioning</subject><subject>Fear extinction</subject><subject>FPS</subject><subject>Heat-rate</subject><subject>Human</subject><subject>Humans</subject><subject>Individual differences</subject><subject>Meta-research</subject><subject>Methods</subject><subject>Neurosciences</subject><subject>Paradigm</subject><subject>Reflex, Startle - physiology</subject><subject>Rodent</subject><subject>SCR</subject><subject>Startle</subject><subject>Translation</subject><subject>Translational Research, Biomedical - methods</subject><subject>Treezing</subject><issn>0149-7634</issn><issn>1873-7528</issn><issn>1873-7528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUGP0zAQhS0EYkvhL4CPXFJsx4kdDkirFbBIi-AAZ8uxJ627iV3sJGiR9r-vQ0sFJ6SRfJjP783MQ-gVJRtKaP1mv_EwtS5EmDeM0GZDcjHyCK2oFGUhKiYfoxWhvClEXfIL9CylPSEZKaun6KKkFaN1I1fo_rO-dX6Lx6h96vXogsc_Q7x9i691HIJ3v5auiSGlIh3AOEh4gHEXbOjD9g47j8cd4BZ2enZhirrHebKMZ9IbwKHDX_Xch9lpjzvQEZvgrVt8svBz9KTTfYIXp3eNvn94_-3qurj58vHT1eVNYbioxiIPC2ArUctlMVpJZrlhrShrqCRvQHYd0SURhlemtJITSllrOG0l4ZrZrlyjd0fdw9QOYA34vG-vDtENOt6poJ36t-PdTm3DrIRkrGZNFnh9EojhxwRpVINLBvpeewhTUow1pMluDcuoOKK_jxahO9tQopbw1F6dw1NLeIrkysms0cu_pzz_-5NWBi6PAORbzQ6iOp3ZughmVDa4_5o8AOG9s_Q</recordid><startdate>20191201</startdate><enddate>20191201</enddate><creator>Haaker, Jan</creator><creator>Maren, Stephen</creator><creator>Andreatta, Marta</creator><creator>Merz, Christian J.</creator><creator>Richter, Jan</creator><creator>Richter, S. Helene</creator><creator>Meir Drexler, Shira</creator><creator>Lange, Maren D.</creator><creator>Jüngling, Kay</creator><creator>Nees, Frauke</creator><creator>Seidenbecher, Thomas</creator><creator>Fullana, Miquel A.</creator><creator>Wotjak, Carsten T.</creator><creator>Lonsdorf, Tina B.</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20191201</creationdate><title>Making translation work: Harmonizing cross-species methodology in the behavioural neuroscience of Pavlovian fear conditioning</title><author>Haaker, Jan ; Maren, Stephen ; Andreatta, Marta ; Merz, Christian J. ; Richter, Jan ; Richter, S. Helene ; Meir Drexler, Shira ; Lange, Maren D. ; Jüngling, Kay ; Nees, Frauke ; Seidenbecher, Thomas ; Fullana, Miquel A. ; Wotjak, Carsten T. ; Lonsdorf, Tina B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-521eed576875281582d4c2b736e5849e8ff0a307c45c3d840112bc41b804a2df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Associative learning</topic><topic>Conditioning, Classical - physiology</topic><topic>Extinction, Psychological - physiology</topic><topic>Fear - physiology</topic><topic>Fear conditioning</topic><topic>Fear extinction</topic><topic>FPS</topic><topic>Heat-rate</topic><topic>Human</topic><topic>Humans</topic><topic>Individual differences</topic><topic>Meta-research</topic><topic>Methods</topic><topic>Neurosciences</topic><topic>Paradigm</topic><topic>Reflex, Startle - physiology</topic><topic>Rodent</topic><topic>SCR</topic><topic>Startle</topic><topic>Translation</topic><topic>Translational Research, Biomedical - methods</topic><topic>Treezing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haaker, Jan</creatorcontrib><creatorcontrib>Maren, Stephen</creatorcontrib><creatorcontrib>Andreatta, Marta</creatorcontrib><creatorcontrib>Merz, Christian J.</creatorcontrib><creatorcontrib>Richter, Jan</creatorcontrib><creatorcontrib>Richter, S. 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Helene</au><au>Meir Drexler, Shira</au><au>Lange, Maren D.</au><au>Jüngling, Kay</au><au>Nees, Frauke</au><au>Seidenbecher, Thomas</au><au>Fullana, Miquel A.</au><au>Wotjak, Carsten T.</au><au>Lonsdorf, Tina B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Making translation work: Harmonizing cross-species methodology in the behavioural neuroscience of Pavlovian fear conditioning</atitle><jtitle>Neuroscience and biobehavioral reviews</jtitle><addtitle>Neurosci Biobehav Rev</addtitle><date>2019-12-01</date><risdate>2019</risdate><volume>107</volume><spage>329</spage><epage>345</epage><pages>329-345</pages><issn>0149-7634</issn><issn>1873-7528</issn><eissn>1873-7528</eissn><abstract>•Considers methodological comparability of translational research in fear conditioning in rodents and humans.•Equips researchers with practical and methodological considerations across species to foster translational behavioural neuroscience.•Aid designing of future experiments that employ more comparable processes in human participants and laboratory rodents in fear conditioning protocols.•Originates from discussions about fear conditioning protocols used in rodents and humans.
Translational neuroscience bridges insights from specific mechanisms in rodents to complex functions in humans and is key to advance our general understanding of central nervous function. A prime example of translational research is the study of cross-species mechanisms that underlie responding to learned threats, by employing Pavlovian fear conditioning protocols in rodents and humans. Hitherto, evidence for (and critique of) these cross-species comparisons in fear conditioning research was based on theoretical viewpoints. Here, we provide a perspective to substantiate these theoretical concepts with empirical considerations of cross-species methodology. This meta-research perspective is expected to foster cross-species comparability and reproducibility to ultimately facilitate successful transfer of results from basic science into clinical applications.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>31521698</pmid><doi>10.1016/j.neubiorev.2019.09.020</doi><tpages>17</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Neuroscience and biobehavioral reviews, 2019-12, Vol.107, p.329-345 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Associative learning Conditioning, Classical - physiology Extinction, Psychological - physiology Fear - physiology Fear conditioning Fear extinction FPS Heat-rate Human Humans Individual differences Meta-research Methods Neurosciences Paradigm Reflex, Startle - physiology Rodent SCR Startle Translation Translational Research, Biomedical - methods Treezing |
| title | Making translation work: Harmonizing cross-species methodology in the behavioural neuroscience of Pavlovian fear conditioning |
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