Diastereoselective Synthesis of 6″‑(Z)- and 6″‑(E)‑Fluoro Analogues of Anti-hepatitis B Virus Agent Entecavir and Its Evaluation of the Activity and Toxicity Profile of the Diastereomers

A method for the diastereoselective synthesis of 6″-(Z)- and 6″‑(E)-fluorinated analogues of the anti-HBV agent entecavir has been developed. Construction of the methylenecyclopentane skeleton of the target molecules has been accomplished by radical-mediated 5-exo-dig cyclization of the selenides 6...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of organic chemistry 2016-04, Vol.81 (7), p.2827-2836
Hauptverfasser: Kumamoto, Hiroki, Fukano, Misato, Nakano, Tomohiko, Iwagami, Keito, Takeyama, Chiaki, Kohgo, Satoru, Imoto, Shuhei, Amano, Masayuki, Kuwata-Higashi, Nobuyo, Aoki, Manabu, Abe, Hiroshi, Mitsuya, Hiroaki, Fukuhara, Kiyoshi, Haraguchi, Kazuhiro
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!