Diastereoselective Synthesis of 6″‑(Z)- and 6″‑(E)‑Fluoro Analogues of Anti-hepatitis B Virus Agent Entecavir and Its Evaluation of the Activity and Toxicity Profile of the Diastereomers
A method for the diastereoselective synthesis of 6″-(Z)- and 6″‑(E)-fluorinated analogues of the anti-HBV agent entecavir has been developed. Construction of the methylenecyclopentane skeleton of the target molecules has been accomplished by radical-mediated 5-exo-dig cyclization of the selenides 6...
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Veröffentlicht in: | Journal of organic chemistry 2016-04, Vol.81 (7), p.2827-2836 |
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Sprache: | eng |
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