Senescence in Post-Mitotic Cells: A Driver of Aging?

Cell senescence was originally defined by an acute loss of replicative capacity and thus believed to be restricted to proliferation-competent cells. More recently, senescence has been recognized as a cellular stress and damage response encompassing multiple pathways or senescence domains, namely DNA...

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Veröffentlicht in:	Antioxidants & redox signaling 2021-02, Vol.34 (4), p.308-323
Hauptverfasser:	von Zglinicki, Thomas, Wan, Tengfei, Miwa, Satomi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Autophagy Cardiac muscle Cell cycle Cell proliferation Cellular stress response Damage DNA damage DNA Damage, Cellular Senescence and Human Aging (Ed. Manlio Vinciguerra) Domains Epigenetics Mammals Mitochondria Muscles Nutrient cycles Phagocytosis Phenotypes Senescence
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