The clonal relation of primary upper urinary tract urothelial carcinoma and paired urothelial carcinoma of the bladder
The risk of developing urothelial carcinoma of the bladder (UCB) in patients treated by radical nephroureterectomy (RNU) for an upper urinary tract urothelial carcinoma (UTUC) is 22% to 47% in the 2 years after surgery. Subject of debate remains whether UTUC and the subsequent UCB are clonally relat...
Gespeichert in:
| Veröffentlicht in: | International journal of cancer 2021-02, Vol.148 (4), p.981-987 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 987 |
|---|---|
| container_issue | 4 |
| container_start_page | 981 |
| container_title | International journal of cancer |
| container_volume | 148 |
| creator | Doeveren, Thomas Nakauma‐Gonzalez, Jose A. Mason, Andrew S. Leenders, Geert J. L. H. Zuiverloon, Tahlita C. M. Zwarthoff, Ellen C. Meijssen, Isabelle C. Made, Angelique C. Heijden, Antoine G. Hendricksen, Kees Rhijn, Bas W. G. Voskuilen, Charlotte S. Riet, Job Dinjens, Winand N. M. Dubbink, Hendrikus J. Werken, Harmen J. G. Boormans, Joost L. |
| description | The risk of developing urothelial carcinoma of the bladder (UCB) in patients treated by radical nephroureterectomy (RNU) for an upper urinary tract urothelial carcinoma (UTUC) is 22% to 47% in the 2 years after surgery. Subject of debate remains whether UTUC and the subsequent UCB are clonally related or represent separate origins. To investigate the clonal relationship between both entities, we performed targeted DNA sequencing of a panel of 41 genes on matched normal and tumor tissue of 15 primary UTUC patients treated by RNU who later developed 19 UCBs. Based on the detected tumor‐specific DNA aberrations, the paired UTUC and UCB(s) of 11 patients (73.3%) showed a clonal relation, whereas in four patients the molecular results did not indicate a clear clonal relationship. Our results support the hypothesis that UCBs following a primary surgically resected UTUC are predominantly clonally derived recurrences and not separate entities.
What's new?
Patients treated by radical nephroureterectomy for upper urinary tract cancer have an increased risk of developing bladder carcinoma following surgery. It remains unclear, however, whether the upper urinary tract cancer and subsequent bladder carcinoma are clonally related or have separate origins. This targeted DNA sequencing study shows that almost 75% of patients have tumors that are clonally related, suggesting that seeding of tumor cells is the main mechanism of bladder carcinoma development following radical nephroureterectomy. This result underscores the need to minimalize the risk of seeding during surgery and/or diagnostic ureterorenoscopy plus biopsy, and to apply peri‐operative intravesical instillations with chemotherapy. |
| doi_str_mv | 10.1002/ijc.33327 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7821318</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2471058002</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5097-abc9aaead25a7c193f15a3598b17dec4897ca49f6f635072a6e5b2238d79cf713</originalsourceid><addsrcrecordid>eNp1kctOwzAQRS0EoqWw4AeQJVYs0vpRx8kGCVU8iiqxKWtr4jjUVRoHJynq3-PSUoEEK2s8x3d85yJ0ScmQEsJGdqmHnHMmj1CfklRGhFFxjPqhRyJJedxDZ02zJIRSQcanqMc5ITGXso_W84XBunQVlNibElrrKuwKXHu7Ar_BXV0bjztvq23VetBtqFy7MKUNTzR4bSu3AgxVjmuw3uR_94NmuMRZCXlu_Dk6KaBszMX-HKDXh_v55CmavTxOJ3ezSIutD8h0CmAgZwKkpikvqAAu0iSjMjd6nKRSwzgt4iLmgkgGsREZYzzJZaqL4HyAbne6dZetTK5NFSyUau9OObDqd6eyC_Xm1komjHKaBIHrvYB3751pWrV0nQ_bahQbS0pEEpYcqJsdpb1rGm-KwwRK1DYiFSJSXxEF9urnlw7kdyYBGO2AD1uazf9Kavo82Ul-AlV6neE</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2471058002</pqid></control><display><type>article</type><title>The clonal relation of primary upper urinary tract urothelial carcinoma and paired urothelial carcinoma of the bladder</title><source>Wiley Online Library Journals Frontfile Complete</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Doeveren, Thomas ; Nakauma‐Gonzalez, Jose A. ; Mason, Andrew S. ; Leenders, Geert J. L. H. ; Zuiverloon, Tahlita C. M. ; Zwarthoff, Ellen C. ; Meijssen, Isabelle C. ; Made, Angelique C. ; Heijden, Antoine G. ; Hendricksen, Kees ; Rhijn, Bas W. G. ; Voskuilen, Charlotte S. ; Riet, Job ; Dinjens, Winand N. M. ; Dubbink, Hendrikus J. ; Werken, Harmen J. G. ; Boormans, Joost L.</creator><creatorcontrib>Doeveren, Thomas ; Nakauma‐Gonzalez, Jose A. ; Mason, Andrew S. ; Leenders, Geert J. L. H. ; Zuiverloon, Tahlita C. M. ; Zwarthoff, Ellen C. ; Meijssen, Isabelle C. ; Made, Angelique C. ; Heijden, Antoine G. ; Hendricksen, Kees ; Rhijn, Bas W. G. ; Voskuilen, Charlotte S. ; Riet, Job ; Dinjens, Winand N. M. ; Dubbink, Hendrikus J. ; Werken, Harmen J. G. ; Boormans, Joost L.</creatorcontrib><description>The risk of developing urothelial carcinoma of the bladder (UCB) in patients treated by radical nephroureterectomy (RNU) for an upper urinary tract urothelial carcinoma (UTUC) is 22% to 47% in the 2 years after surgery. Subject of debate remains whether UTUC and the subsequent UCB are clonally related or represent separate origins. To investigate the clonal relationship between both entities, we performed targeted DNA sequencing of a panel of 41 genes on matched normal and tumor tissue of 15 primary UTUC patients treated by RNU who later developed 19 UCBs. Based on the detected tumor‐specific DNA aberrations, the paired UTUC and UCB(s) of 11 patients (73.3%) showed a clonal relation, whereas in four patients the molecular results did not indicate a clear clonal relationship. Our results support the hypothesis that UCBs following a primary surgically resected UTUC are predominantly clonally derived recurrences and not separate entities.
What's new?
Patients treated by radical nephroureterectomy for upper urinary tract cancer have an increased risk of developing bladder carcinoma following surgery. It remains unclear, however, whether the upper urinary tract cancer and subsequent bladder carcinoma are clonally related or have separate origins. This targeted DNA sequencing study shows that almost 75% of patients have tumors that are clonally related, suggesting that seeding of tumor cells is the main mechanism of bladder carcinoma development following radical nephroureterectomy. This result underscores the need to minimalize the risk of seeding during surgery and/or diagnostic ureterorenoscopy plus biopsy, and to apply peri‐operative intravesical instillations with chemotherapy.</description><identifier>ISSN: 0020-7136</identifier><identifier>EISSN: 1097-0215</identifier><identifier>DOI: 10.1002/ijc.33327</identifier><identifier>PMID: 33006377</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Bladder cancer ; bladder carcinoma ; Cancer ; clonality ; Deoxyribonucleic acid ; DNA ; DNA sequencing ; Medical research ; Molecular Cancer Biology ; Surgery ; upper urinary tract carcinoma ; Urinary tract ; Urogenital system ; Urothelial carcinoma</subject><ispartof>International journal of cancer, 2021-02, Vol.148 (4), p.981-987</ispartof><rights>2020 The Authors. published by John Wiley & Sons Ltd on behalf of Union for International Cancer Control.</rights><rights>2020 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of Union for International Cancer Control.</rights><rights>2020. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5097-abc9aaead25a7c193f15a3598b17dec4897ca49f6f635072a6e5b2238d79cf713</citedby><cites>FETCH-LOGICAL-c5097-abc9aaead25a7c193f15a3598b17dec4897ca49f6f635072a6e5b2238d79cf713</cites><orcidid>0000-0002-9794-1477 ; 0000-0002-2160-5207 ; 0000-0002-9853-4953 ; 0000-0002-8222-3974 ; 0000-0002-7580-106X ; 0000-0002-9697-4293 ; 0000-0002-8839-8601 ; 0000-0002-9298-8380 ; 0000-0002-6507-118X ; 0000-0002-5127-0436 ; 0000-0003-2176-9102 ; 0000-0003-0991-0812 ; 0000-0001-7767-7923</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fijc.33327$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fijc.33327$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33006377$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Doeveren, Thomas</creatorcontrib><creatorcontrib>Nakauma‐Gonzalez, Jose A.</creatorcontrib><creatorcontrib>Mason, Andrew S.</creatorcontrib><creatorcontrib>Leenders, Geert J. L. H.</creatorcontrib><creatorcontrib>Zuiverloon, Tahlita C. M.</creatorcontrib><creatorcontrib>Zwarthoff, Ellen C.</creatorcontrib><creatorcontrib>Meijssen, Isabelle C.</creatorcontrib><creatorcontrib>Made, Angelique C.</creatorcontrib><creatorcontrib>Heijden, Antoine G.</creatorcontrib><creatorcontrib>Hendricksen, Kees</creatorcontrib><creatorcontrib>Rhijn, Bas W. G.</creatorcontrib><creatorcontrib>Voskuilen, Charlotte S.</creatorcontrib><creatorcontrib>Riet, Job</creatorcontrib><creatorcontrib>Dinjens, Winand N. M.</creatorcontrib><creatorcontrib>Dubbink, Hendrikus J.</creatorcontrib><creatorcontrib>Werken, Harmen J. G.</creatorcontrib><creatorcontrib>Boormans, Joost L.</creatorcontrib><title>The clonal relation of primary upper urinary tract urothelial carcinoma and paired urothelial carcinoma of the bladder</title><title>International journal of cancer</title><addtitle>Int J Cancer</addtitle><description>The risk of developing urothelial carcinoma of the bladder (UCB) in patients treated by radical nephroureterectomy (RNU) for an upper urinary tract urothelial carcinoma (UTUC) is 22% to 47% in the 2 years after surgery. Subject of debate remains whether UTUC and the subsequent UCB are clonally related or represent separate origins. To investigate the clonal relationship between both entities, we performed targeted DNA sequencing of a panel of 41 genes on matched normal and tumor tissue of 15 primary UTUC patients treated by RNU who later developed 19 UCBs. Based on the detected tumor‐specific DNA aberrations, the paired UTUC and UCB(s) of 11 patients (73.3%) showed a clonal relation, whereas in four patients the molecular results did not indicate a clear clonal relationship. Our results support the hypothesis that UCBs following a primary surgically resected UTUC are predominantly clonally derived recurrences and not separate entities.
What's new?
Patients treated by radical nephroureterectomy for upper urinary tract cancer have an increased risk of developing bladder carcinoma following surgery. It remains unclear, however, whether the upper urinary tract cancer and subsequent bladder carcinoma are clonally related or have separate origins. This targeted DNA sequencing study shows that almost 75% of patients have tumors that are clonally related, suggesting that seeding of tumor cells is the main mechanism of bladder carcinoma development following radical nephroureterectomy. This result underscores the need to minimalize the risk of seeding during surgery and/or diagnostic ureterorenoscopy plus biopsy, and to apply peri‐operative intravesical instillations with chemotherapy.</description><subject>Bladder cancer</subject><subject>bladder carcinoma</subject><subject>Cancer</subject><subject>clonality</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA sequencing</subject><subject>Medical research</subject><subject>Molecular Cancer Biology</subject><subject>Surgery</subject><subject>upper urinary tract carcinoma</subject><subject>Urinary tract</subject><subject>Urogenital system</subject><subject>Urothelial carcinoma</subject><issn>0020-7136</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><recordid>eNp1kctOwzAQRS0EoqWw4AeQJVYs0vpRx8kGCVU8iiqxKWtr4jjUVRoHJynq3-PSUoEEK2s8x3d85yJ0ScmQEsJGdqmHnHMmj1CfklRGhFFxjPqhRyJJedxDZ02zJIRSQcanqMc5ITGXso_W84XBunQVlNibElrrKuwKXHu7Ar_BXV0bjztvq23VetBtqFy7MKUNTzR4bSu3AgxVjmuw3uR_94NmuMRZCXlu_Dk6KaBszMX-HKDXh_v55CmavTxOJ3ezSIutD8h0CmAgZwKkpikvqAAu0iSjMjd6nKRSwzgt4iLmgkgGsREZYzzJZaqL4HyAbne6dZetTK5NFSyUau9OObDqd6eyC_Xm1komjHKaBIHrvYB3751pWrV0nQ_bahQbS0pEEpYcqJsdpb1rGm-KwwRK1DYiFSJSXxEF9urnlw7kdyYBGO2AD1uazf9Kavo82Ul-AlV6neE</recordid><startdate>20210215</startdate><enddate>20210215</enddate><creator>Doeveren, Thomas</creator><creator>Nakauma‐Gonzalez, Jose A.</creator><creator>Mason, Andrew S.</creator><creator>Leenders, Geert J. L. H.</creator><creator>Zuiverloon, Tahlita C. M.</creator><creator>Zwarthoff, Ellen C.</creator><creator>Meijssen, Isabelle C.</creator><creator>Made, Angelique C.</creator><creator>Heijden, Antoine G.</creator><creator>Hendricksen, Kees</creator><creator>Rhijn, Bas W. G.</creator><creator>Voskuilen, Charlotte S.</creator><creator>Riet, Job</creator><creator>Dinjens, Winand N. M.</creator><creator>Dubbink, Hendrikus J.</creator><creator>Werken, Harmen J. G.</creator><creator>Boormans, Joost L.</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9794-1477</orcidid><orcidid>https://orcid.org/0000-0002-2160-5207</orcidid><orcidid>https://orcid.org/0000-0002-9853-4953</orcidid><orcidid>https://orcid.org/0000-0002-8222-3974</orcidid><orcidid>https://orcid.org/0000-0002-7580-106X</orcidid><orcidid>https://orcid.org/0000-0002-9697-4293</orcidid><orcidid>https://orcid.org/0000-0002-8839-8601</orcidid><orcidid>https://orcid.org/0000-0002-9298-8380</orcidid><orcidid>https://orcid.org/0000-0002-6507-118X</orcidid><orcidid>https://orcid.org/0000-0002-5127-0436</orcidid><orcidid>https://orcid.org/0000-0003-2176-9102</orcidid><orcidid>https://orcid.org/0000-0003-0991-0812</orcidid><orcidid>https://orcid.org/0000-0001-7767-7923</orcidid></search><sort><creationdate>20210215</creationdate><title>The clonal relation of primary upper urinary tract urothelial carcinoma and paired urothelial carcinoma of the bladder</title><author>Doeveren, Thomas ; Nakauma‐Gonzalez, Jose A. ; Mason, Andrew S. ; Leenders, Geert J. L. H. ; Zuiverloon, Tahlita C. M. ; Zwarthoff, Ellen C. ; Meijssen, Isabelle C. ; Made, Angelique C. ; Heijden, Antoine G. ; Hendricksen, Kees ; Rhijn, Bas W. G. ; Voskuilen, Charlotte S. ; Riet, Job ; Dinjens, Winand N. M. ; Dubbink, Hendrikus J. ; Werken, Harmen J. G. ; Boormans, Joost L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5097-abc9aaead25a7c193f15a3598b17dec4897ca49f6f635072a6e5b2238d79cf713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Bladder cancer</topic><topic>bladder carcinoma</topic><topic>Cancer</topic><topic>clonality</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA sequencing</topic><topic>Medical research</topic><topic>Molecular Cancer Biology</topic><topic>Surgery</topic><topic>upper urinary tract carcinoma</topic><topic>Urinary tract</topic><topic>Urogenital system</topic><topic>Urothelial carcinoma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Doeveren, Thomas</creatorcontrib><creatorcontrib>Nakauma‐Gonzalez, Jose A.</creatorcontrib><creatorcontrib>Mason, Andrew S.</creatorcontrib><creatorcontrib>Leenders, Geert J. L. H.</creatorcontrib><creatorcontrib>Zuiverloon, Tahlita C. M.</creatorcontrib><creatorcontrib>Zwarthoff, Ellen C.</creatorcontrib><creatorcontrib>Meijssen, Isabelle C.</creatorcontrib><creatorcontrib>Made, Angelique C.</creatorcontrib><creatorcontrib>Heijden, Antoine G.</creatorcontrib><creatorcontrib>Hendricksen, Kees</creatorcontrib><creatorcontrib>Rhijn, Bas W. G.</creatorcontrib><creatorcontrib>Voskuilen, Charlotte S.</creatorcontrib><creatorcontrib>Riet, Job</creatorcontrib><creatorcontrib>Dinjens, Winand N. M.</creatorcontrib><creatorcontrib>Dubbink, Hendrikus J.</creatorcontrib><creatorcontrib>Werken, Harmen J. G.</creatorcontrib><creatorcontrib>Boormans, Joost L.</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Online Library Free Content</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Doeveren, Thomas</au><au>Nakauma‐Gonzalez, Jose A.</au><au>Mason, Andrew S.</au><au>Leenders, Geert J. L. H.</au><au>Zuiverloon, Tahlita C. M.</au><au>Zwarthoff, Ellen C.</au><au>Meijssen, Isabelle C.</au><au>Made, Angelique C.</au><au>Heijden, Antoine G.</au><au>Hendricksen, Kees</au><au>Rhijn, Bas W. G.</au><au>Voskuilen, Charlotte S.</au><au>Riet, Job</au><au>Dinjens, Winand N. M.</au><au>Dubbink, Hendrikus J.</au><au>Werken, Harmen J. G.</au><au>Boormans, Joost L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The clonal relation of primary upper urinary tract urothelial carcinoma and paired urothelial carcinoma of the bladder</atitle><jtitle>International journal of cancer</jtitle><addtitle>Int J Cancer</addtitle><date>2021-02-15</date><risdate>2021</risdate><volume>148</volume><issue>4</issue><spage>981</spage><epage>987</epage><pages>981-987</pages><issn>0020-7136</issn><eissn>1097-0215</eissn><abstract>The risk of developing urothelial carcinoma of the bladder (UCB) in patients treated by radical nephroureterectomy (RNU) for an upper urinary tract urothelial carcinoma (UTUC) is 22% to 47% in the 2 years after surgery. Subject of debate remains whether UTUC and the subsequent UCB are clonally related or represent separate origins. To investigate the clonal relationship between both entities, we performed targeted DNA sequencing of a panel of 41 genes on matched normal and tumor tissue of 15 primary UTUC patients treated by RNU who later developed 19 UCBs. Based on the detected tumor‐specific DNA aberrations, the paired UTUC and UCB(s) of 11 patients (73.3%) showed a clonal relation, whereas in four patients the molecular results did not indicate a clear clonal relationship. Our results support the hypothesis that UCBs following a primary surgically resected UTUC are predominantly clonally derived recurrences and not separate entities.
What's new?
Patients treated by radical nephroureterectomy for upper urinary tract cancer have an increased risk of developing bladder carcinoma following surgery. It remains unclear, however, whether the upper urinary tract cancer and subsequent bladder carcinoma are clonally related or have separate origins. This targeted DNA sequencing study shows that almost 75% of patients have tumors that are clonally related, suggesting that seeding of tumor cells is the main mechanism of bladder carcinoma development following radical nephroureterectomy. This result underscores the need to minimalize the risk of seeding during surgery and/or diagnostic ureterorenoscopy plus biopsy, and to apply peri‐operative intravesical instillations with chemotherapy.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>33006377</pmid><doi>10.1002/ijc.33327</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-9794-1477</orcidid><orcidid>https://orcid.org/0000-0002-2160-5207</orcidid><orcidid>https://orcid.org/0000-0002-9853-4953</orcidid><orcidid>https://orcid.org/0000-0002-8222-3974</orcidid><orcidid>https://orcid.org/0000-0002-7580-106X</orcidid><orcidid>https://orcid.org/0000-0002-9697-4293</orcidid><orcidid>https://orcid.org/0000-0002-8839-8601</orcidid><orcidid>https://orcid.org/0000-0002-9298-8380</orcidid><orcidid>https://orcid.org/0000-0002-6507-118X</orcidid><orcidid>https://orcid.org/0000-0002-5127-0436</orcidid><orcidid>https://orcid.org/0000-0003-2176-9102</orcidid><orcidid>https://orcid.org/0000-0003-0991-0812</orcidid><orcidid>https://orcid.org/0000-0001-7767-7923</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0020-7136 |
| ispartof | International journal of cancer, 2021-02, Vol.148 (4), p.981-987 |
| issn | 0020-7136 1097-0215 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7821318 |
| source | Wiley Online Library Journals Frontfile Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Bladder cancer bladder carcinoma Cancer clonality Deoxyribonucleic acid DNA DNA sequencing Medical research Molecular Cancer Biology Surgery upper urinary tract carcinoma Urinary tract Urogenital system Urothelial carcinoma |
| title | The clonal relation of primary upper urinary tract urothelial carcinoma and paired urothelial carcinoma of the bladder |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T10%3A49%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20clonal%20relation%20of%20primary%20upper%20urinary%20tract%20urothelial%20carcinoma%20and%20paired%20urothelial%20carcinoma%20of%20the%20bladder&rft.jtitle=International%20journal%20of%20cancer&rft.au=Doeveren,%20Thomas&rft.date=2021-02-15&rft.volume=148&rft.issue=4&rft.spage=981&rft.epage=987&rft.pages=981-987&rft.issn=0020-7136&rft.eissn=1097-0215&rft_id=info:doi/10.1002/ijc.33327&rft_dat=%3Cproquest_pubme%3E2471058002%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2471058002&rft_id=info:pmid/33006377&rfr_iscdi=true |