Selective Affimers Recognise the BCL‐2 Family Proteins BCL‐xL and MCL‐1 through Noncanonical Structural Motifs

: The BCL‐2 family is a challenging group of proteins to target selectively due to sequence and structural homologies across the family. Selective ligands for the BCL‐2 family regulators of apoptosis are useful as probes to understand cell biology and apoptotic signalling pathways, and as starting p...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2021-01, Vol.22 (1), p.232-240
Hauptverfasser:	Miles, Jennifer A., Hobor, Fruzsina, Trinh, Chi H., Taylor, James, Tiede, Christian, Rowell, Philip R., Jackson, Brian R., Nadat, Fatima A., Ramsahye, Pallavi, Kyle, Hannah F., Wicky, Basile I. M., Clarke, Jane, Tomlinson, Darren C., Wilson, Andrew J., Edwards, Thomas A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Affimers BCL-2 family chemical biology non-antibody-binding proteins protein-protein interactions
Online-Zugang:	Volltext
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