Thermocoagulation versus cryotherapy for the treatment of cervical precancers
Aim To compare thermocoagulation and cryotherapy for treatment of high‐grade cervical intraepithelial neoplasia (CIN). Methods From May 2017 to May 2018, women with CIN2/3 were randomized to thermocoagulation or cryotherapy at Peking University Shenzhen Hospital. Follow‐up at 4 and 8 months included...
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| Veröffentlicht in: | The journal of obstetrics and gynaecology research 2021-01, Vol.47 (1), p.279-286 |
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| container_title | The journal of obstetrics and gynaecology research |
| container_volume | 47 |
| creator | Duan, Lyufang Du, Hui Belinson, Jerome L. Liu, Zhihong Xiao, Aimin Liu, Shuangyan Zhao, Liwei Wang, Chun Qu, Xinfeng Wu, Ruifang |
| description | Aim
To compare thermocoagulation and cryotherapy for treatment of high‐grade cervical intraepithelial neoplasia (CIN).
Methods
From May 2017 to May 2018, women with CIN2/3 were randomized to thermocoagulation or cryotherapy at Peking University Shenzhen Hospital. Follow‐up at 4 and 8 months included cytology and human papillomavirus (HPV) testing. Women who were HPV‐positive or had atypical squamous cells of undetermined significance or higher‐grade disease underwent colposcopy/biopsy.
Results
Among 149 women enrolled, 74 were randomized to thermocoagulation, and 75 to cryotherapy (excluded four were immediately referred for thermocoagulation due to large lesions). At follow‐up, there was no difference between the thermocoagulation and cryotherapy groups in HPV‐negative (4/8 months: 72.5%/86.2% vs 68.6%/80.6%) and pathology‐negative (97.1%/98.5% vs 94.3%/92.3%) rates (all P > 0.05). The cytology‐negative rate was similar for thermocoagulation and cryotherapy at 4 months (79.7% vs 78.9%, P > 0.05), but higher for thermocoagulation at 8 months (100% vs 88.7%, P |
| doi_str_mv | 10.1111/jog.14520 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7820992</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2475618519</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4670-323d3453d664ddf943983ae64c55afb2e0afe876761b25e695ebe320c63f6d9e3</originalsourceid><addsrcrecordid>eNp1kUtLxDAUhYMojq-Ff0AKbnRRJ6-mzUYQ8YkyG12HTHrb6dA2NWlH-u-NjooKZnNvuF8OJ_cgdEjwGQlnurTlGeEJxRtoh3CexjhNxGboGSdxhlMxQbveLzEmqSTZNpowhjMpiNxBj08LcI01VpdDrfvKttEKnB98ZNxo-zDU3RgV1kWhj3oHum-g7SNbRAbcqjK6jjoHRrfh6vfRVqFrDwefdQ89X189Xd7GD7Obu8uLh9hwkeKYUZYznrBcCJ7nheRMZkyD4CZJdDGngHUBWSpSQeY0ASETmAOj2AhWiFwC20Pna91umDeQm-DI6Vp1rmq0G5XVlfo9aauFKu1KpRnFUtIgcPIp4OzLAL5XTeUN1LVuwQ5e0eBOZJwKEdDjP-jSDq4N3wtU2DPJEiIDdbqmjLPeOyi-zRCs3kMKr0r1EVJgj366_ya_UgnAdA28VjWM_yup-9nNWvING6-dCQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2475618519</pqid></control><display><type>article</type><title>Thermocoagulation versus cryotherapy for the treatment of cervical precancers</title><source>Access via Wiley Online Library</source><creator>Duan, Lyufang ; Du, Hui ; Belinson, Jerome L. ; Liu, Zhihong ; Xiao, Aimin ; Liu, Shuangyan ; Zhao, Liwei ; Wang, Chun ; Qu, Xinfeng ; Wu, Ruifang</creator><creatorcontrib>Duan, Lyufang ; Du, Hui ; Belinson, Jerome L. ; Liu, Zhihong ; Xiao, Aimin ; Liu, Shuangyan ; Zhao, Liwei ; Wang, Chun ; Qu, Xinfeng ; Wu, Ruifang</creatorcontrib><description>Aim
To compare thermocoagulation and cryotherapy for treatment of high‐grade cervical intraepithelial neoplasia (CIN).
Methods
From May 2017 to May 2018, women with CIN2/3 were randomized to thermocoagulation or cryotherapy at Peking University Shenzhen Hospital. Follow‐up at 4 and 8 months included cytology and human papillomavirus (HPV) testing. Women who were HPV‐positive or had atypical squamous cells of undetermined significance or higher‐grade disease underwent colposcopy/biopsy.
Results
Among 149 women enrolled, 74 were randomized to thermocoagulation, and 75 to cryotherapy (excluded four were immediately referred for thermocoagulation due to large lesions). At follow‐up, there was no difference between the thermocoagulation and cryotherapy groups in HPV‐negative (4/8 months: 72.5%/86.2% vs 68.6%/80.6%) and pathology‐negative (97.1%/98.5% vs 94.3%/92.3%) rates (all P > 0.05). The cytology‐negative rate was similar for thermocoagulation and cryotherapy at 4 months (79.7% vs 78.9%, P > 0.05), but higher for thermocoagulation at 8 months (100% vs 88.7%, P < 0.05). No lesions were observed among the four referral women at follow‐up. As compared with cryotherapy, thermocoagulation was associated with shorter duration of treatment and less vaginal discharge, but higher pain during application and longer bleeding after treatment.
Conclusion
Thermocoagulation was as effective and safe as cryotherapy and might be easily applied to treat high‐grade cervical lesions.</description><identifier>ISSN: 1341-8076</identifier><identifier>EISSN: 1447-0756</identifier><identifier>DOI: 10.1111/jog.14520</identifier><identifier>PMID: 33089619</identifier><language>eng</language><publisher>Kyoto, Japan: John Wiley & Sons Australia, Ltd</publisher><subject>Ablation ; Biopsy ; Cellular biology ; cervical intraepithelial neoplasia ; Colposcopy ; complication ; Cryotherapy ; Cytology ; efficacy ; Human papillomavirus ; Lesions ; Original ; Squamous cells ; thermocoagulation ; treatment ; Vagina</subject><ispartof>The journal of obstetrics and gynaecology research, 2021-01, Vol.47 (1), p.279-286</ispartof><rights>2020 The Authors. published by John Wiley & Sons Australia, Ltd on behalf of Japan Society of Obstetrics and Gynecology.</rights><rights>2020 The Authors. Journal of Obstetrics and Gynaecology Research published by John Wiley & Sons Australia, Ltd on behalf of Japan Society of Obstetrics and Gynecology.</rights><rights>2020. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4670-323d3453d664ddf943983ae64c55afb2e0afe876761b25e695ebe320c63f6d9e3</citedby><cites>FETCH-LOGICAL-c4670-323d3453d664ddf943983ae64c55afb2e0afe876761b25e695ebe320c63f6d9e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjog.14520$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjog.14520$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33089619$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Duan, Lyufang</creatorcontrib><creatorcontrib>Du, Hui</creatorcontrib><creatorcontrib>Belinson, Jerome L.</creatorcontrib><creatorcontrib>Liu, Zhihong</creatorcontrib><creatorcontrib>Xiao, Aimin</creatorcontrib><creatorcontrib>Liu, Shuangyan</creatorcontrib><creatorcontrib>Zhao, Liwei</creatorcontrib><creatorcontrib>Wang, Chun</creatorcontrib><creatorcontrib>Qu, Xinfeng</creatorcontrib><creatorcontrib>Wu, Ruifang</creatorcontrib><title>Thermocoagulation versus cryotherapy for the treatment of cervical precancers</title><title>The journal of obstetrics and gynaecology research</title><addtitle>J Obstet Gynaecol Res</addtitle><description>Aim
To compare thermocoagulation and cryotherapy for treatment of high‐grade cervical intraepithelial neoplasia (CIN).
Methods
From May 2017 to May 2018, women with CIN2/3 were randomized to thermocoagulation or cryotherapy at Peking University Shenzhen Hospital. Follow‐up at 4 and 8 months included cytology and human papillomavirus (HPV) testing. Women who were HPV‐positive or had atypical squamous cells of undetermined significance or higher‐grade disease underwent colposcopy/biopsy.
Results
Among 149 women enrolled, 74 were randomized to thermocoagulation, and 75 to cryotherapy (excluded four were immediately referred for thermocoagulation due to large lesions). At follow‐up, there was no difference between the thermocoagulation and cryotherapy groups in HPV‐negative (4/8 months: 72.5%/86.2% vs 68.6%/80.6%) and pathology‐negative (97.1%/98.5% vs 94.3%/92.3%) rates (all P > 0.05). The cytology‐negative rate was similar for thermocoagulation and cryotherapy at 4 months (79.7% vs 78.9%, P > 0.05), but higher for thermocoagulation at 8 months (100% vs 88.7%, P < 0.05). No lesions were observed among the four referral women at follow‐up. As compared with cryotherapy, thermocoagulation was associated with shorter duration of treatment and less vaginal discharge, but higher pain during application and longer bleeding after treatment.
Conclusion
Thermocoagulation was as effective and safe as cryotherapy and might be easily applied to treat high‐grade cervical lesions.</description><subject>Ablation</subject><subject>Biopsy</subject><subject>Cellular biology</subject><subject>cervical intraepithelial neoplasia</subject><subject>Colposcopy</subject><subject>complication</subject><subject>Cryotherapy</subject><subject>Cytology</subject><subject>efficacy</subject><subject>Human papillomavirus</subject><subject>Lesions</subject><subject>Original</subject><subject>Squamous cells</subject><subject>thermocoagulation</subject><subject>treatment</subject><subject>Vagina</subject><issn>1341-8076</issn><issn>1447-0756</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><recordid>eNp1kUtLxDAUhYMojq-Ff0AKbnRRJ6-mzUYQ8YkyG12HTHrb6dA2NWlH-u-NjooKZnNvuF8OJ_cgdEjwGQlnurTlGeEJxRtoh3CexjhNxGboGSdxhlMxQbveLzEmqSTZNpowhjMpiNxBj08LcI01VpdDrfvKttEKnB98ZNxo-zDU3RgV1kWhj3oHum-g7SNbRAbcqjK6jjoHRrfh6vfRVqFrDwefdQ89X189Xd7GD7Obu8uLh9hwkeKYUZYznrBcCJ7nheRMZkyD4CZJdDGngHUBWSpSQeY0ASETmAOj2AhWiFwC20Pna91umDeQm-DI6Vp1rmq0G5XVlfo9aauFKu1KpRnFUtIgcPIp4OzLAL5XTeUN1LVuwQ5e0eBOZJwKEdDjP-jSDq4N3wtU2DPJEiIDdbqmjLPeOyi-zRCs3kMKr0r1EVJgj366_ya_UgnAdA28VjWM_yup-9nNWvING6-dCQ</recordid><startdate>202101</startdate><enddate>202101</enddate><creator>Duan, Lyufang</creator><creator>Du, Hui</creator><creator>Belinson, Jerome L.</creator><creator>Liu, Zhihong</creator><creator>Xiao, Aimin</creator><creator>Liu, Shuangyan</creator><creator>Zhao, Liwei</creator><creator>Wang, Chun</creator><creator>Qu, Xinfeng</creator><creator>Wu, Ruifang</creator><general>John Wiley & Sons Australia, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TO</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>202101</creationdate><title>Thermocoagulation versus cryotherapy for the treatment of cervical precancers</title><author>Duan, Lyufang ; Du, Hui ; Belinson, Jerome L. ; Liu, Zhihong ; Xiao, Aimin ; Liu, Shuangyan ; Zhao, Liwei ; Wang, Chun ; Qu, Xinfeng ; Wu, Ruifang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4670-323d3453d664ddf943983ae64c55afb2e0afe876761b25e695ebe320c63f6d9e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Ablation</topic><topic>Biopsy</topic><topic>Cellular biology</topic><topic>cervical intraepithelial neoplasia</topic><topic>Colposcopy</topic><topic>complication</topic><topic>Cryotherapy</topic><topic>Cytology</topic><topic>efficacy</topic><topic>Human papillomavirus</topic><topic>Lesions</topic><topic>Original</topic><topic>Squamous cells</topic><topic>thermocoagulation</topic><topic>treatment</topic><topic>Vagina</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Duan, Lyufang</creatorcontrib><creatorcontrib>Du, Hui</creatorcontrib><creatorcontrib>Belinson, Jerome L.</creatorcontrib><creatorcontrib>Liu, Zhihong</creatorcontrib><creatorcontrib>Xiao, Aimin</creatorcontrib><creatorcontrib>Liu, Shuangyan</creatorcontrib><creatorcontrib>Zhao, Liwei</creatorcontrib><creatorcontrib>Wang, Chun</creatorcontrib><creatorcontrib>Qu, Xinfeng</creatorcontrib><creatorcontrib>Wu, Ruifang</creatorcontrib><collection>Wiley Online Library (Open Access Collection)</collection><collection>Wiley Online Library (Open Access Collection)</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The journal of obstetrics and gynaecology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Duan, Lyufang</au><au>Du, Hui</au><au>Belinson, Jerome L.</au><au>Liu, Zhihong</au><au>Xiao, Aimin</au><au>Liu, Shuangyan</au><au>Zhao, Liwei</au><au>Wang, Chun</au><au>Qu, Xinfeng</au><au>Wu, Ruifang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thermocoagulation versus cryotherapy for the treatment of cervical precancers</atitle><jtitle>The journal of obstetrics and gynaecology research</jtitle><addtitle>J Obstet Gynaecol Res</addtitle><date>2021-01</date><risdate>2021</risdate><volume>47</volume><issue>1</issue><spage>279</spage><epage>286</epage><pages>279-286</pages><issn>1341-8076</issn><eissn>1447-0756</eissn><abstract>Aim
To compare thermocoagulation and cryotherapy for treatment of high‐grade cervical intraepithelial neoplasia (CIN).
Methods
From May 2017 to May 2018, women with CIN2/3 were randomized to thermocoagulation or cryotherapy at Peking University Shenzhen Hospital. Follow‐up at 4 and 8 months included cytology and human papillomavirus (HPV) testing. Women who were HPV‐positive or had atypical squamous cells of undetermined significance or higher‐grade disease underwent colposcopy/biopsy.
Results
Among 149 women enrolled, 74 were randomized to thermocoagulation, and 75 to cryotherapy (excluded four were immediately referred for thermocoagulation due to large lesions). At follow‐up, there was no difference between the thermocoagulation and cryotherapy groups in HPV‐negative (4/8 months: 72.5%/86.2% vs 68.6%/80.6%) and pathology‐negative (97.1%/98.5% vs 94.3%/92.3%) rates (all P > 0.05). The cytology‐negative rate was similar for thermocoagulation and cryotherapy at 4 months (79.7% vs 78.9%, P > 0.05), but higher for thermocoagulation at 8 months (100% vs 88.7%, P < 0.05). No lesions were observed among the four referral women at follow‐up. As compared with cryotherapy, thermocoagulation was associated with shorter duration of treatment and less vaginal discharge, but higher pain during application and longer bleeding after treatment.
Conclusion
Thermocoagulation was as effective and safe as cryotherapy and might be easily applied to treat high‐grade cervical lesions.</abstract><cop>Kyoto, Japan</cop><pub>John Wiley & Sons Australia, Ltd</pub><pmid>33089619</pmid><doi>10.1111/jog.14520</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The journal of obstetrics and gynaecology research, 2021-01, Vol.47 (1), p.279-286 |
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| language | eng |
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| subjects | Ablation Biopsy Cellular biology cervical intraepithelial neoplasia Colposcopy complication Cryotherapy Cytology efficacy Human papillomavirus Lesions Original Squamous cells thermocoagulation treatment Vagina |
| title | Thermocoagulation versus cryotherapy for the treatment of cervical precancers |
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