Systemic AAV6-synapsin-GFP administration results in lower liver biodistribution, compared to AAV1&2 and AAV9, with neuronal expression following ultrasound-mediated brain delivery

Non-surgical gene delivery to the brain can be achieved following intravenous injection of viral vectors coupled with transcranial MRI-guided focused ultrasound (MRIgFUS) to temporarily and locally permeabilize the blood–brain barrier. Vector and promoter selection can provide neuronal expression in...

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Veröffentlicht in:	Scientific reports 2021-01, Vol.11 (1), p.1934, Article 1934
Hauptverfasser:	Weber-Adrian, Danielle, Kofoed, Rikke Hahn, Silburt, Joseph, Noroozian, Zeinab, Shah, Kairavi, Burgess, Alison, Rideout, Shawna, Kügler, Sebastian, Hynynen, Kullervo, Aubert, Isabelle
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/1341 631/378/340 Animals Blood-brain barrier Blood-Brain Barrier - drug effects Brain - diagnostic imaging Brain - drug effects Brain - metabolism Dependovirus - genetics Gene transfer Genetic Therapy Genetic Vectors - therapeutic use Green fluorescent protein Green Fluorescent Proteins - chemistry Green Fluorescent Proteins - pharmacology Hippocampus Humanities and Social Sciences Humans Injection Injections, Intravenous Intravenous administration Liver Liver - diagnostic imaging Liver - drug effects Magnetic Resonance Imaging Mice multidisciplinary Neostriatum Neurons - drug effects Promoter Regions, Genetic Science Science (multidisciplinary) Serotypes Synapsin Synapsins - chemistry Synapsins - pharmacology Tissue Distribution Transduction, Genetic Ultrasonic imaging Ultrasonography Ultrasound
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