Acral lentiginous melanoma: Basic facts, biological characteristics and research perspectives of an understudied disease
Acral lentiginous melanoma is a histological subtype of cutaneous melanoma that occurs in the glabrous skin of the palms, soles and the nail unit. Although in some countries, particularly in Latin America, Africa and Asia, it represents the most frequently diagnosed subtype of the disease, it only r...
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| Veröffentlicht in: | Pigment cell and melanoma research 2021-01, Vol.34 (1), p.59-71 |
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| creator | Basurto‐Lozada, Patricia Molina‐Aguilar, Christian Castaneda‐Garcia, Carolina Vázquez‐Cruz, Martha Estefania Garcia‐Salinas, Omar Isaac Álvarez‐Cano, Alethia Martínez‐Said, Héctor Roldán‐Marín, Rodrigo Adams, David J. Possik, Patricia A. Robles‐Espinoza, Carla Daniela |
| description | Acral lentiginous melanoma is a histological subtype of cutaneous melanoma that occurs in the glabrous skin of the palms, soles and the nail unit. Although in some countries, particularly in Latin America, Africa and Asia, it represents the most frequently diagnosed subtype of the disease, it only represents a small proportion of melanoma cases in European‐descent populations, which is partially why it has not been studied to the same extent as other forms of melanoma. As a result, its unique genomic drivers remain comparatively poorly explored, as well as its causes, with current evidence supporting a UV‐independent path to tumorigenesis. In this review, we discuss current knowledge of the aetiology and diagnostic criteria of acral lentiginous melanoma, as well as its epidemiological and histopathological characteristics. We also describe what is known about the genomic landscape of this disease and review the available biological models to explore potential therapeutic targets. |
| doi_str_mv | 10.1111/pcmr.12885 |
| format | Article |
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Although in some countries, particularly in Latin America, Africa and Asia, it represents the most frequently diagnosed subtype of the disease, it only represents a small proportion of melanoma cases in European‐descent populations, which is partially why it has not been studied to the same extent as other forms of melanoma. As a result, its unique genomic drivers remain comparatively poorly explored, as well as its causes, with current evidence supporting a UV‐independent path to tumorigenesis. In this review, we discuss current knowledge of the aetiology and diagnostic criteria of acral lentiginous melanoma, as well as its epidemiological and histopathological characteristics. 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We also describe what is known about the genomic landscape of this disease and review the available biological models to explore potential therapeutic targets.</description><subject>acral melanoma</subject><subject>Biological models (mathematics)</subject><subject>diagnosis</subject><subject>Diagnostic systems</subject><subject>Epidemiology</subject><subject>Foot Diseases - pathology</subject><subject>genomics</subject><subject>Humans</subject><subject>Melanocytes - pathology</subject><subject>Melanoma</subject><subject>Melanoma - pathology</subject><subject>microenvironment</subject><subject>Nail Diseases - pathology</subject><subject>Review</subject><subject>Reviews</subject><subject>Skin Neoplasms - pathology</subject><subject>Tumorigenesis</subject><issn>1755-1471</issn><issn>1755-148X</issn><issn>1755-148X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp9kU2LFDEQhhtR3HX14g-QgBcRZ81Xd5I9COvgF6woouAtpCvVM1m6O23Svbr_3oyzDurBXCpUPbzUW29VPWT0lJX3fIIhnTKudX2rOmaqrldM6q-3D3_Fjqp7OV9S2tDaiLvVkeBCUNGo4-rHOSTXkx7HOWzCGJdMBuzdGAd3Rl66HIB0Dub8jLQh9nEToNCwdak0MYU8B8jEjZ4kzOgSbMmEKU8Ic7jCTGJXhmQZfWnOiw_oiQ8FzHi_utO5PuODm3pSfXn96vP67eriw5t36_OLFdRM1qtG-ZoJKg13DIThjHkQnW5Mw4EbwFZ1XrAWW0mR11oyMLQznQbqlXQMxUn1Yq87Le2AHorRYthOKQwuXdvogv17Moat3cQrqzTTksoi8ORGIMVvC-bZDiED9uVIWM5luTBSK90IVtDH_6CXcUljsWe5VLw2Spmd4NM9BSnmnLA7LMOo3QVqd4HaX4EW-NGf6x_Q3wkWgO2B76HH6_9I2Y_r95_2oj8BJKuuKQ</recordid><startdate>202101</startdate><enddate>202101</enddate><creator>Basurto‐Lozada, Patricia</creator><creator>Molina‐Aguilar, Christian</creator><creator>Castaneda‐Garcia, Carolina</creator><creator>Vázquez‐Cruz, Martha Estefania</creator><creator>Garcia‐Salinas, Omar Isaac</creator><creator>Álvarez‐Cano, Alethia</creator><creator>Martínez‐Said, Héctor</creator><creator>Roldán‐Marín, Rodrigo</creator><creator>Adams, David J.</creator><creator>Possik, Patricia A.</creator><creator>Robles‐Espinoza, Carla Daniela</creator><general>Wiley Subscription Services, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TO</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9490-0306</orcidid><orcidid>https://orcid.org/0000-0003-2899-0969</orcidid><orcidid>https://orcid.org/0000-0003-3277-7466</orcidid></search><sort><creationdate>202101</creationdate><title>Acral lentiginous melanoma: Basic facts, biological characteristics and research perspectives of an understudied disease</title><author>Basurto‐Lozada, Patricia ; 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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | acral melanoma Biological models (mathematics) diagnosis Diagnostic systems Epidemiology Foot Diseases - pathology genomics Humans Melanocytes - pathology Melanoma Melanoma - pathology microenvironment Nail Diseases - pathology Review Reviews Skin Neoplasms - pathology Tumorigenesis |
| title | Acral lentiginous melanoma: Basic facts, biological characteristics and research perspectives of an understudied disease |
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