The common marmoset as suitable nonhuman alternative for the analysis of primate cochlear development
Cochlear development is a complex process with precise spatiotemporal patterns. A detailed understanding of this process is important for studies of congenital hearing loss and regenerative medicine. However, much of our understanding of cochlear development is based on rodent models. Animal models...
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| Veröffentlicht in: | The FEBS journal 2021-01, Vol.288 (1), p.325-353 |
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| creator | Hosoya, Makoto Fujioka, Masato Murayama, Ayako Y. Okano, Hideyuki Ogawa, Kaoru |
| description | Cochlear development is a complex process with precise spatiotemporal patterns. A detailed understanding of this process is important for studies of congenital hearing loss and regenerative medicine. However, much of our understanding of cochlear development is based on rodent models. Animal models that bridge the gap between humans and rodents are needed. In this study, we investigated the development of hearing organs in a small New World monkey species, the common marmoset (Callithrix jacchus). We describe the general stages of cochlear development in comparison with those of humans and mice. Moreover, we examined more than 25 proteins involved in cochlear development and found that expression patterns were generally conserved between rodents and primates. However, several proteins involved in supporting cell processes and neuronal development exhibited interspecific expression differences. Human fetal samples for studies of primate‐specific cochlear development are extremely rare, especially for late developmental stages. Our results support the use of the common marmoset as an effective alternative for analyses of primate cochlear development.
We investigated cochlear development in a small New World monkey species, the common marmoset (Callithrix jacchus). We found that expression patterns of the proteins involved in cochlear development were generally conserved between rodents and primates. However, several proteins involved in supporting cell processes and neuronal development exhibited interspecific expression differences. Our results support the use of the common marmoset as an effective alternative for analyses of primate cochlear development. |
| doi_str_mv | 10.1111/febs.15341 |
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We investigated cochlear development in a small New World monkey species, the common marmoset (Callithrix jacchus). We found that expression patterns of the proteins involved in cochlear development were generally conserved between rodents and primates. However, several proteins involved in supporting cell processes and neuronal development exhibited interspecific expression differences. Our results support the use of the common marmoset as an effective alternative for analyses of primate cochlear development.</description><identifier>ISSN: 1742-464X</identifier><identifier>EISSN: 1742-4658</identifier><identifier>DOI: 10.1111/febs.15341</identifier><identifier>PMID: 32323465</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Animal models ; Cochlea ; common marmoset ; Developmental stages ; Fetuses ; Hearing ; Hearing loss ; inner ear ; Interspecific ; Organs ; Original ; primate ; Primates ; Proteins ; Regenerative medicine ; Rodents</subject><ispartof>The FEBS journal, 2021-01, Vol.288 (1), p.325-353</ispartof><rights>2020 The Authors. The published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies</rights><rights>2020 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.</rights><rights>2020. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5141-420640fb8fa68f6493b92ad52a4b7b0d85c9f106e14a543817cafa3b68a7653</citedby><cites>FETCH-LOGICAL-c5141-420640fb8fa68f6493b92ad52a4b7b0d85c9f106e14a543817cafa3b68a7653</cites><orcidid>0000-0002-5317-0885</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Ffebs.15341$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Ffebs.15341$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,1416,1432,27922,27923,45572,45573,46407,46831</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32323465$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hosoya, Makoto</creatorcontrib><creatorcontrib>Fujioka, Masato</creatorcontrib><creatorcontrib>Murayama, Ayako Y.</creatorcontrib><creatorcontrib>Okano, Hideyuki</creatorcontrib><creatorcontrib>Ogawa, Kaoru</creatorcontrib><title>The common marmoset as suitable nonhuman alternative for the analysis of primate cochlear development</title><title>The FEBS journal</title><addtitle>FEBS J</addtitle><description>Cochlear development is a complex process with precise spatiotemporal patterns. A detailed understanding of this process is important for studies of congenital hearing loss and regenerative medicine. However, much of our understanding of cochlear development is based on rodent models. Animal models that bridge the gap between humans and rodents are needed. In this study, we investigated the development of hearing organs in a small New World monkey species, the common marmoset (Callithrix jacchus). We describe the general stages of cochlear development in comparison with those of humans and mice. Moreover, we examined more than 25 proteins involved in cochlear development and found that expression patterns were generally conserved between rodents and primates. However, several proteins involved in supporting cell processes and neuronal development exhibited interspecific expression differences. Human fetal samples for studies of primate‐specific cochlear development are extremely rare, especially for late developmental stages. Our results support the use of the common marmoset as an effective alternative for analyses of primate cochlear development.
We investigated cochlear development in a small New World monkey species, the common marmoset (Callithrix jacchus). We found that expression patterns of the proteins involved in cochlear development were generally conserved between rodents and primates. However, several proteins involved in supporting cell processes and neuronal development exhibited interspecific expression differences. Our results support the use of the common marmoset as an effective alternative for analyses of primate cochlear development.</description><subject>Animal models</subject><subject>Cochlea</subject><subject>common marmoset</subject><subject>Developmental stages</subject><subject>Fetuses</subject><subject>Hearing</subject><subject>Hearing loss</subject><subject>inner ear</subject><subject>Interspecific</subject><subject>Organs</subject><subject>Original</subject><subject>primate</subject><subject>Primates</subject><subject>Proteins</subject><subject>Regenerative medicine</subject><subject>Rodents</subject><issn>1742-464X</issn><issn>1742-4658</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><recordid>eNp9kU9rHCEYxqU0NGnaSz5AEXoJhU11dBznEmhC_kEgh-TQm7wz-9qd4J-NzmzZb183my5pD9GDgj9_PvgQcsTZCS_ju8Uun_BaSP6OHPBGVjOpav1-t5c_98nHnB8ZE7Vs2w9kX1RlFuiA4MMCaR-9j4F6SD5mHClkmqdhhM4hDTEsJg-BghsxBRiHFVIbEx3LRQjg1nnINFq6TIOHcSPrFw4h0Tmu0MWlxzB-InsWXMbPL-shub-8eDi_nt3eXd2c_7id9TWXfCYrpiSznbagtFWyFV1bwbyuQHZNx-a67lvLmUIuoZZC86YHC6JTGhpVi0NyurUup87jvC8PJ3DmOVhamwiD-fckDAvzK65Mo7muRFsExy-CFJ8mzKPxQ-7ROQgYp2wKIyvFZNMU9Ot_6GOcyve4QslGat4qwQv1bUv1Keac0O7CcGY23ZlNd-a5uwJ_eR1_h_4tqwB8C_weHK7fUJnLi7P7rfQPWeCmLA</recordid><startdate>202101</startdate><enddate>202101</enddate><creator>Hosoya, Makoto</creator><creator>Fujioka, Masato</creator><creator>Murayama, Ayako Y.</creator><creator>Okano, Hideyuki</creator><creator>Ogawa, Kaoru</creator><general>Blackwell Publishing Ltd</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5317-0885</orcidid></search><sort><creationdate>202101</creationdate><title>The common marmoset as suitable nonhuman alternative for the analysis of primate cochlear development</title><author>Hosoya, Makoto ; Fujioka, Masato ; Murayama, Ayako Y. ; Okano, Hideyuki ; Ogawa, Kaoru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5141-420640fb8fa68f6493b92ad52a4b7b0d85c9f106e14a543817cafa3b68a7653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animal models</topic><topic>Cochlea</topic><topic>common marmoset</topic><topic>Developmental stages</topic><topic>Fetuses</topic><topic>Hearing</topic><topic>Hearing loss</topic><topic>inner ear</topic><topic>Interspecific</topic><topic>Organs</topic><topic>Original</topic><topic>primate</topic><topic>Primates</topic><topic>Proteins</topic><topic>Regenerative medicine</topic><topic>Rodents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hosoya, Makoto</creatorcontrib><creatorcontrib>Fujioka, Masato</creatorcontrib><creatorcontrib>Murayama, Ayako Y.</creatorcontrib><creatorcontrib>Okano, Hideyuki</creatorcontrib><creatorcontrib>Ogawa, Kaoru</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The FEBS journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hosoya, Makoto</au><au>Fujioka, Masato</au><au>Murayama, Ayako Y.</au><au>Okano, Hideyuki</au><au>Ogawa, Kaoru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The common marmoset as suitable nonhuman alternative for the analysis of primate cochlear development</atitle><jtitle>The FEBS journal</jtitle><addtitle>FEBS J</addtitle><date>2021-01</date><risdate>2021</risdate><volume>288</volume><issue>1</issue><spage>325</spage><epage>353</epage><pages>325-353</pages><issn>1742-464X</issn><eissn>1742-4658</eissn><abstract>Cochlear development is a complex process with precise spatiotemporal patterns. A detailed understanding of this process is important for studies of congenital hearing loss and regenerative medicine. However, much of our understanding of cochlear development is based on rodent models. Animal models that bridge the gap between humans and rodents are needed. In this study, we investigated the development of hearing organs in a small New World monkey species, the common marmoset (Callithrix jacchus). We describe the general stages of cochlear development in comparison with those of humans and mice. Moreover, we examined more than 25 proteins involved in cochlear development and found that expression patterns were generally conserved between rodents and primates. However, several proteins involved in supporting cell processes and neuronal development exhibited interspecific expression differences. Human fetal samples for studies of primate‐specific cochlear development are extremely rare, especially for late developmental stages. Our results support the use of the common marmoset as an effective alternative for analyses of primate cochlear development.
We investigated cochlear development in a small New World monkey species, the common marmoset (Callithrix jacchus). We found that expression patterns of the proteins involved in cochlear development were generally conserved between rodents and primates. However, several proteins involved in supporting cell processes and neuronal development exhibited interspecific expression differences. Our results support the use of the common marmoset as an effective alternative for analyses of primate cochlear development.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>32323465</pmid><doi>10.1111/febs.15341</doi><tpages>29</tpages><orcidid>https://orcid.org/0000-0002-5317-0885</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animal models Cochlea common marmoset Developmental stages Fetuses Hearing Hearing loss inner ear Interspecific Organs Original primate Primates Proteins Regenerative medicine Rodents |
| title | The common marmoset as suitable nonhuman alternative for the analysis of primate cochlear development |
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