Effects of the herbal medicine Rikkunshito, for functional dyspepsia: A systematic review and meta‐analysis
Background and Aim Functional dyspepsia (FD) is characterized by chronic and unexplained indigestion at upper abdomen. Because of unsatisfactory effect of conventional treatments, demand is growing for complementary and alternative medicine. Rikkunshito (RKT) is a herbal medicine, which has been wid...
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| Veröffentlicht in: | Journal of gastroenterology and hepatology 2021-01, Vol.36 (1), p.64-74 |
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| creator | Ko, Seok‐Jae Park, Jiseon Kim, Min‐ji Kim, Jinsung Park, Jae‐Woo |
| description | Background and Aim
Functional dyspepsia (FD) is characterized by chronic and unexplained indigestion at upper abdomen. Because of unsatisfactory effect of conventional treatments, demand is growing for complementary and alternative medicine. Rikkunshito (RKT) is a herbal medicine, which has been widely used for FD in Asia; however, the evidence is lacking. We carried out systematic review and meta‐analysis to evaluate the effect and safety of RKT in the treatment of FD.
Methods
Electronic databases were searched in April 2019, including PUBMED, EMBASE, and Cochrane Library. All eligible studies should be randomized controlled trials (RCTs) comparing RKT or combination therapy (RKT and western medicine) group to western medicine group. The primary outcome measure was the total clinical efficacy rate (TCE). The secondary outcomes were total dyspepsia symptom scale, gastric emptying rate, gastrin, motilin, recurrence 6 months after treatment, and Hamilton depression rating scale.
Results
Fifty‐two RCTs with 5475 patients were involved in this systematic review and meta‐analysis. Compared with western medicine, RKT showed significant better result, with higher TCE (relative risk = 1.21, 95% confidence interval 1.17 to 1.25, P |
| doi_str_mv | 10.1111/jgh.15208 |
| format | Article |
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Functional dyspepsia (FD) is characterized by chronic and unexplained indigestion at upper abdomen. Because of unsatisfactory effect of conventional treatments, demand is growing for complementary and alternative medicine. Rikkunshito (RKT) is a herbal medicine, which has been widely used for FD in Asia; however, the evidence is lacking. We carried out systematic review and meta‐analysis to evaluate the effect and safety of RKT in the treatment of FD.
Methods
Electronic databases were searched in April 2019, including PUBMED, EMBASE, and Cochrane Library. All eligible studies should be randomized controlled trials (RCTs) comparing RKT or combination therapy (RKT and western medicine) group to western medicine group. The primary outcome measure was the total clinical efficacy rate (TCE). The secondary outcomes were total dyspepsia symptom scale, gastric emptying rate, gastrin, motilin, recurrence 6 months after treatment, and Hamilton depression rating scale.
Results
Fifty‐two RCTs with 5475 patients were involved in this systematic review and meta‐analysis. Compared with western medicine, RKT showed significant better result, with higher TCE (relative risk = 1.21, 95% confidence interval 1.17 to 1.25, P < 0.001). RKT presented higher reduction of total dyspepsia symptom scale, more improved gastric emptying rate, and lower recurrence 6 months after treatment compared with western medicine. However, there was no significant difference in Hamilton depression rating scale between RKT and western medicine group. Combination therapy brought significant symptom improvement with TCE compared with western medicine alone.
Conclusions
Rikkunshito and combination therapy might be considered an effective alternative treatment for FD. Further rigorously designed and high‐quality RCTs are needed.</description><identifier>ISSN: 0815-9319</identifier><identifier>EISSN: 1440-1746</identifier><identifier>DOI: 10.1111/jgh.15208</identifier><identifier>PMID: 32767596</identifier><language>eng</language><publisher>Australia: Wiley Subscription Services, Inc</publisher><subject>Clinical trials ; Dyspepsia ; Functional dyspepsia ; Gastric emptying ; Gastrin ; Herbal medicine ; Medicine ; Meta Analysis and Systematic Review ; Meta-analysis ; Regular ; Rikkunshito ; Systematic review ; Western medicine</subject><ispartof>Journal of gastroenterology and hepatology, 2021-01, Vol.36 (1), p.64-74</ispartof><rights>2020 The Authors. Journal of Gastroenterology and Hepatology published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd</rights><rights>2020 The Authors. Journal of Gastroenterology and Hepatology published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.</rights><rights>2020. This article is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5098-512ad5f2d792b1fe3afc7b4c403933d6e7776a11a363a0833721f3f6bc934493</citedby><cites>FETCH-LOGICAL-c5098-512ad5f2d792b1fe3afc7b4c403933d6e7776a11a363a0833721f3f6bc934493</cites><orcidid>0000-0002-9902-0938</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjgh.15208$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjgh.15208$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32767596$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ko, Seok‐Jae</creatorcontrib><creatorcontrib>Park, Jiseon</creatorcontrib><creatorcontrib>Kim, Min‐ji</creatorcontrib><creatorcontrib>Kim, Jinsung</creatorcontrib><creatorcontrib>Park, Jae‐Woo</creatorcontrib><title>Effects of the herbal medicine Rikkunshito, for functional dyspepsia: A systematic review and meta‐analysis</title><title>Journal of gastroenterology and hepatology</title><addtitle>J Gastroenterol Hepatol</addtitle><description>Background and Aim
Functional dyspepsia (FD) is characterized by chronic and unexplained indigestion at upper abdomen. Because of unsatisfactory effect of conventional treatments, demand is growing for complementary and alternative medicine. Rikkunshito (RKT) is a herbal medicine, which has been widely used for FD in Asia; however, the evidence is lacking. We carried out systematic review and meta‐analysis to evaluate the effect and safety of RKT in the treatment of FD.
Methods
Electronic databases were searched in April 2019, including PUBMED, EMBASE, and Cochrane Library. All eligible studies should be randomized controlled trials (RCTs) comparing RKT or combination therapy (RKT and western medicine) group to western medicine group. The primary outcome measure was the total clinical efficacy rate (TCE). The secondary outcomes were total dyspepsia symptom scale, gastric emptying rate, gastrin, motilin, recurrence 6 months after treatment, and Hamilton depression rating scale.
Results
Fifty‐two RCTs with 5475 patients were involved in this systematic review and meta‐analysis. Compared with western medicine, RKT showed significant better result, with higher TCE (relative risk = 1.21, 95% confidence interval 1.17 to 1.25, P < 0.001). RKT presented higher reduction of total dyspepsia symptom scale, more improved gastric emptying rate, and lower recurrence 6 months after treatment compared with western medicine. However, there was no significant difference in Hamilton depression rating scale between RKT and western medicine group. Combination therapy brought significant symptom improvement with TCE compared with western medicine alone.
Conclusions
Rikkunshito and combination therapy might be considered an effective alternative treatment for FD. Further rigorously designed and high‐quality RCTs are needed.</description><subject>Clinical trials</subject><subject>Dyspepsia</subject><subject>Functional dyspepsia</subject><subject>Gastric emptying</subject><subject>Gastrin</subject><subject>Herbal medicine</subject><subject>Medicine</subject><subject>Meta Analysis and Systematic Review</subject><subject>Meta-analysis</subject><subject>Regular</subject><subject>Rikkunshito</subject><subject>Systematic review</subject><subject>Western medicine</subject><issn>0815-9319</issn><issn>1440-1746</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><recordid>eNp10c1qFTEYBuAgij22LrwBCbhR6LT5mUySLoRS-qMUCtJ9yGSSTk5nJsck0zI7L8Fr9EpMPbWoYDbfIg8v38cLwBuMDnB5h-ub_gAzgsQzsMJ1jSrM6-Y5WCGBWSUpljvgVUprhFCNOHsJdijhDWeyWYHx1DlrcoLBwdxb2NvY6gGOtvPGTxZ-8be385R6n8M-dCFCN08m-zAV1C1pYzfJ6yN4DNOSsh119gZGe-ftPdRTV3Ky_vHtuy58ST7tgRdOD8m-fpy74Prs9Prkorq8Ov90cnxZGYakqBgmumOOdFySFjtLtTO8rU2NqKS0ayznvNEYa9pQjQSlnGBHXdMaSeta0l3wcRu7mdtyibFTjnpQm-hHHRcVtFd__0y-VzfhTnGBBZaoBLx_DIjh62xTVqNPxg6DnmyYkyI1xYIwQXih7_6h6zDHcu-D4lxIKSgr6sNWmRhSitY9LYOReuhQlQ7Vrw6Lffvn9k_yd2kFHG7BvR_s8v8k9fn8Yhv5E_YJp_s</recordid><startdate>202101</startdate><enddate>202101</enddate><creator>Ko, Seok‐Jae</creator><creator>Park, Jiseon</creator><creator>Kim, Min‐ji</creator><creator>Kim, Jinsung</creator><creator>Park, Jae‐Woo</creator><general>Wiley Subscription Services, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9902-0938</orcidid></search><sort><creationdate>202101</creationdate><title>Effects of the herbal medicine Rikkunshito, for functional dyspepsia: A systematic review and meta‐analysis</title><author>Ko, Seok‐Jae ; Park, Jiseon ; Kim, Min‐ji ; Kim, Jinsung ; Park, Jae‐Woo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5098-512ad5f2d792b1fe3afc7b4c403933d6e7776a11a363a0833721f3f6bc934493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Clinical trials</topic><topic>Dyspepsia</topic><topic>Functional dyspepsia</topic><topic>Gastric emptying</topic><topic>Gastrin</topic><topic>Herbal medicine</topic><topic>Medicine</topic><topic>Meta Analysis and Systematic Review</topic><topic>Meta-analysis</topic><topic>Regular</topic><topic>Rikkunshito</topic><topic>Systematic review</topic><topic>Western medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ko, Seok‐Jae</creatorcontrib><creatorcontrib>Park, Jiseon</creatorcontrib><creatorcontrib>Kim, Min‐ji</creatorcontrib><creatorcontrib>Kim, Jinsung</creatorcontrib><creatorcontrib>Park, Jae‐Woo</creatorcontrib><collection>Wiley Online Library (Open Access Collection)</collection><collection>Wiley Online Library (Open Access Collection)</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of gastroenterology and hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ko, Seok‐Jae</au><au>Park, Jiseon</au><au>Kim, Min‐ji</au><au>Kim, Jinsung</au><au>Park, Jae‐Woo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of the herbal medicine Rikkunshito, for functional dyspepsia: A systematic review and meta‐analysis</atitle><jtitle>Journal of gastroenterology and hepatology</jtitle><addtitle>J Gastroenterol Hepatol</addtitle><date>2021-01</date><risdate>2021</risdate><volume>36</volume><issue>1</issue><spage>64</spage><epage>74</epage><pages>64-74</pages><issn>0815-9319</issn><eissn>1440-1746</eissn><abstract>Background and Aim
Functional dyspepsia (FD) is characterized by chronic and unexplained indigestion at upper abdomen. Because of unsatisfactory effect of conventional treatments, demand is growing for complementary and alternative medicine. Rikkunshito (RKT) is a herbal medicine, which has been widely used for FD in Asia; however, the evidence is lacking. We carried out systematic review and meta‐analysis to evaluate the effect and safety of RKT in the treatment of FD.
Methods
Electronic databases were searched in April 2019, including PUBMED, EMBASE, and Cochrane Library. All eligible studies should be randomized controlled trials (RCTs) comparing RKT or combination therapy (RKT and western medicine) group to western medicine group. The primary outcome measure was the total clinical efficacy rate (TCE). The secondary outcomes were total dyspepsia symptom scale, gastric emptying rate, gastrin, motilin, recurrence 6 months after treatment, and Hamilton depression rating scale.
Results
Fifty‐two RCTs with 5475 patients were involved in this systematic review and meta‐analysis. Compared with western medicine, RKT showed significant better result, with higher TCE (relative risk = 1.21, 95% confidence interval 1.17 to 1.25, P < 0.001). RKT presented higher reduction of total dyspepsia symptom scale, more improved gastric emptying rate, and lower recurrence 6 months after treatment compared with western medicine. However, there was no significant difference in Hamilton depression rating scale between RKT and western medicine group. Combination therapy brought significant symptom improvement with TCE compared with western medicine alone.
Conclusions
Rikkunshito and combination therapy might be considered an effective alternative treatment for FD. Further rigorously designed and high‐quality RCTs are needed.</abstract><cop>Australia</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32767596</pmid><doi>10.1111/jgh.15208</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-9902-0938</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Clinical trials Dyspepsia Functional dyspepsia Gastric emptying Gastrin Herbal medicine Medicine Meta Analysis and Systematic Review Meta-analysis Regular Rikkunshito Systematic review Western medicine |
| title | Effects of the herbal medicine Rikkunshito, for functional dyspepsia: A systematic review and meta‐analysis |
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