Pulmonary MTBVAC vaccination induces immune signatures previously correlated with prevention of tuberculosis infection

To fight tuberculosis, better vaccination strategies are needed. Live attenuated Mycobacterium tuberculosis-derived vaccine, MTBVAC, is a promising candidate in the pipeline, proven to be safe and immunogenic in humans so far. Independent studies have shown that pulmonary mucosal delivery of Bacillu...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell reports. Medicine 2021-01, Vol.2 (1), p.100187-100187, Article 100187
Hauptverfasser:	Dijkman, Karin, Aguilo, Nacho, Boot, Charelle, Hofman, Sam O., Sombroek, Claudia C., Vervenne, Richard A.W., Kocken, Clemens H.M., Marinova, Dessislava, Thole, Jelle, Rodríguez, Esteban, Vierboom, Michel P.M., Haanstra, Krista G., Puentes, Eugenia, Martin, Carlos, Verreck, Frank A.W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Animals antibodies BCG BCG Vaccine - administration & dosage Cellular Reprogramming - genetics Cellular Reprogramming - immunology Female Gene Expression Regulation immune correlates Immunity, Mucosal Injections, Intradermal Interleukin-10 - genetics Interleukin-10 - immunology Interleukin-17 - genetics Interleukin-17 - immunology Lung - drug effects Lung - immunology Lung - microbiology Macaca mulatta Male Monocytes - drug effects Monocytes - immunology Monocytes - microbiology MTBVAC mucosal immunity Mycobacterium tuberculosis - immunology Mycobacterium tuberculosis - pathogenicity non-human primate Respiratory Mucosa - immunology Respiratory Mucosa - microbiology Th1 Cells - immunology Th1 Cells - microbiology Th1/Th17 Th17 Cells - immunology Th17 Cells - microbiology tissue-resident memory tuberculosis Tuberculosis Vaccines - administration & dosage Tuberculosis, Pulmonary - genetics Tuberculosis, Pulmonary - immunology Tuberculosis, Pulmonary - microbiology Tuberculosis, Pulmonary - prevention & control Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - immunology vaccination
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!