Cigarette smoke induces miR-132 in Th17 cells that enhance osteoclastogenesis in inflammatory arthritis

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by joint destruction and severe morbidity. Cigarette smoking (CS) can exacerbate the incidence and severity of RA. Although Th17 cells and the Aryl hydrocarbon receptor (AhR) have been implicated, the mechanism by which CS ind...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2021-01, Vol.118 (1), p.1-8
Hauptverfasser:	Donate, Paula B., de Lima, Kalil Alves, Peres, Raphael S., Almeida, Fausto, Fukada, Sandra Y., Silva, Tarcilia A., Nascimento, Daniele C., Cecilio, Nerry T., Talbot, Jhimmy, Oliveira, Rene D., Passos, Geraldo A., Alves-Filho, José Carlos, Cunha, Thiago M., Louzada-Junior, Paulo, Liew, Foo Y., Cunha, Fernando Q.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Animal models Animals Aromatic compounds Arthritis Arthritis, Experimental - pathology Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - metabolism Arthritis, Rheumatoid - pathology Basic Helix-Loop-Helix Transcription Factors - metabolism Biological Sciences Biomedical materials Cigarette smoke Cigarette smoking Cigarette Smoking - adverse effects Cigarettes Cyclooxygenase-2 Down-regulation Environmental factors Environmental impact Female Helper cells Humans Inflammatory diseases Joint diseases Lymphocytes T Male Mice Mice, Inbred C57BL MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Middle Aged miRNA Morbidity Osteoclastogenesis Osteoclasts Osteoclasts - metabolism Osteogenesis - drug effects Osteogenesis - physiology Pathogenesis Receptors, Aryl Hydrocarbon - metabolism Rheumatoid arthritis Ribonucleic acid RNA Smoke Smoking Th17 Cells - drug effects Th17 Cells - metabolism Tobacco Smoke Pollution - adverse effects
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