The evolution of skin pigmentation-associated variation in West Eurasia

Skin pigmentation is a classic example of a polygenic trait that has experienced directional selection in humans. Genome-wide association studies have identified well over a hundred pigmentation-associated loci, and genomic scans in present-day and ancient populations have identified selective sweep...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2021-01, Vol.118 (1), p.1-8
Hauptverfasser:	Ju, Dan, Mathieson, Iain
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Asia Asian Continental Ancestry Group - genetics Biobanks Biological Evolution Biological Sciences Databases, Genetic Deoxyribonucleic acid DNA DNA, Ancient - analysis Europe European Continental Ancestry Group - genetics Gene Frequency - genetics Genetic diversity Genome-wide association studies Genome-Wide Association Study - methods Genomes Genotype Haplotypes - genetics Humans Multifactorial Inheritance - genetics Phenotypic variations Pigmentation Polygenic inheritance Polymorphism, Single Nucleotide - genetics Populations Selection, Genetic - genetics Skin Skin pigmentation Skin Pigmentation - genetics Skin Pigmentation - physiology Stone Age
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