Binding of the SARS-CoV-2 spike protein to glycans

This study systematically investigated the binding of the subunits and spike (S) proteins of SARS-CoV-2 and SARS-CoV, MERS-CoV to heparan sulfate (HS) and sialic acid-containing glycans. Our results revealed that all the tested protein molecules can bind to HS in a sulfation-dependent manner and no...

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Veröffentlicht in:	Science bulletin (Beijing) 2021-06, Vol.66 (12), p.1205-1214
Hauptverfasser:	Hao, Wei, Ma, Bo, Li, Ziheng, Wang, Xiaoyu, Gao, Xiaopan, Li, Yaohao, Qin, Bo, Shang, Shiying, Cui, Sheng, Tan, Zhongping
Format:	Artikel
Sprache:	eng
Schlagworte:	Glycan microarray Heparan sulfate SARS-CoV-2 S protein Sialic acid Sulfation Surface plasmon resonance
Online-Zugang:	Volltext
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