Altered urinary tetrahydroisoquinoline derivatives in patients with Tourette syndrome: reflection of dopaminergic hyperactivity?
Tetrahydroisoquinolines (TIQs) such as salsolinol (SAL), norsalsolinol (NSAL) and their methylated derivatives N-methyl-norsalsolinol (NMNSAL) and N -methyl-salsolinol (NMSAL), modulate dopaminergic neurotransmission and metabolism in the central nervous system. Dopaminergic neurotransmission is tho...
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| Veröffentlicht in: | Journal of Neural Transmission 2021-01, Vol.128 (1), p.115-120 |
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| creator | Capetian, Philipp Roessner, Veit Korte, Caroline Walitza, Susanne Riederer, Franz Taurines, Regina Gerlach, Manfred Moser, Andreas |
| description | Tetrahydroisoquinolines (TIQs) such as salsolinol (SAL), norsalsolinol (NSAL) and their methylated derivatives N-methyl-norsalsolinol (NMNSAL) and
N
-methyl-salsolinol (NMSAL), modulate dopaminergic neurotransmission and metabolism in the central nervous system. Dopaminergic neurotransmission is thought to play an important role in the pathophysiology of chronic tic disorders, such as Tourette syndrome (TS). Therefore, the urinary concentrations of these TIQ derivatives were measured in patients with TS and patients with comorbid attention-deficit/hyperactivity disorder (TS + ADHD) compared with controls. Seventeen patients with TS, 12 with TS and ADHD, and 19 age-matched healthy controls with no medication took part in this study. Free levels of NSAL, NMNSAL, SAL, and NMSAL in urine were measured by a two-phase chromatographic approach. Furthermore, individual TIQ concentrations in TS patients were used in receiver-operating characteristics (ROC) curve analysis to examine the diagnostic value. NSAL concentrations were elevated significantly in TS [434.67 ± 55.4 nmol/l (standard error of mean = S.E.M.), two-way ANOVA,
p
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| doi_str_mv | 10.1007/s00702-020-02289-6 |
| format | Article |
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N
-methyl-salsolinol (NMSAL), modulate dopaminergic neurotransmission and metabolism in the central nervous system. Dopaminergic neurotransmission is thought to play an important role in the pathophysiology of chronic tic disorders, such as Tourette syndrome (TS). Therefore, the urinary concentrations of these TIQ derivatives were measured in patients with TS and patients with comorbid attention-deficit/hyperactivity disorder (TS + ADHD) compared with controls. Seventeen patients with TS, 12 with TS and ADHD, and 19 age-matched healthy controls with no medication took part in this study. Free levels of NSAL, NMNSAL, SAL, and NMSAL in urine were measured by a two-phase chromatographic approach. Furthermore, individual TIQ concentrations in TS patients were used in receiver-operating characteristics (ROC) curve analysis to examine the diagnostic value. NSAL concentrations were elevated significantly in TS [434.67 ± 55.4 nmol/l (standard error of mean = S.E.M.), two-way ANOVA,
p
< 0.0001] and TS + ADHD patients [605.18 ± 170.21 nmol/l (S.E.M.), two-way ANOVA,
p
< 0.0001] compared with controls [107.02 ± 33.18 nmol/l (S.E.M.), two-way ANOVA,
p
< 0.0001] and NSAL levels in TS + ADHD patients were elevated significantly in comparison with TS patients (two-way ANOVA,
p
= 0.017). NSAL demonstrated an AUC of 0.93 ± 0.046 (S.E.M) the highest diagnostic value of all metabolites for the diagnosis of TS. Our results suggest a dopaminergic hyperactivity underlying the pathophysiology of TS and ADHD. In addition, NSAL concentrations in urine may be a potential diagnostic biomarker of TS.</description><identifier>ISSN: 0300-9564</identifier><identifier>EISSN: 1435-1463</identifier><identifier>DOI: 10.1007/s00702-020-02289-6</identifier><identifier>PMID: 33355691</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Attention Deficit Disorder with Hyperactivity ; Humans ; Medicine ; Medicine & Public Health ; Neurology ; Neurosciences ; Psychiatry ; Psychiatry and Preclinical Psychiatric Studies - Original ; Psychiatry and Preclinical Psychiatric Studies - Original Article ; Tetrahydroisoquinolines ; Tic Disorders ; Tourette Syndrome</subject><ispartof>Journal of Neural Transmission, 2021-01, Vol.128 (1), p.115-120</ispartof><rights>The Author(s) 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c446t-7f459574d147d753e81ea87207c601d819f3b7a614d13173461f8261212b4bee3</citedby><cites>FETCH-LOGICAL-c446t-7f459574d147d753e81ea87207c601d819f3b7a614d13173461f8261212b4bee3</cites><orcidid>0000-0003-1712-3659</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00702-020-02289-6$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00702-020-02289-6$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33355691$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Capetian, Philipp</creatorcontrib><creatorcontrib>Roessner, Veit</creatorcontrib><creatorcontrib>Korte, Caroline</creatorcontrib><creatorcontrib>Walitza, Susanne</creatorcontrib><creatorcontrib>Riederer, Franz</creatorcontrib><creatorcontrib>Taurines, Regina</creatorcontrib><creatorcontrib>Gerlach, Manfred</creatorcontrib><creatorcontrib>Moser, Andreas</creatorcontrib><title>Altered urinary tetrahydroisoquinoline derivatives in patients with Tourette syndrome: reflection of dopaminergic hyperactivity?</title><title>Journal of Neural Transmission</title><addtitle>J Neural Transm</addtitle><addtitle>J Neural Transm (Vienna)</addtitle><description>Tetrahydroisoquinolines (TIQs) such as salsolinol (SAL), norsalsolinol (NSAL) and their methylated derivatives N-methyl-norsalsolinol (NMNSAL) and
N
-methyl-salsolinol (NMSAL), modulate dopaminergic neurotransmission and metabolism in the central nervous system. Dopaminergic neurotransmission is thought to play an important role in the pathophysiology of chronic tic disorders, such as Tourette syndrome (TS). Therefore, the urinary concentrations of these TIQ derivatives were measured in patients with TS and patients with comorbid attention-deficit/hyperactivity disorder (TS + ADHD) compared with controls. Seventeen patients with TS, 12 with TS and ADHD, and 19 age-matched healthy controls with no medication took part in this study. Free levels of NSAL, NMNSAL, SAL, and NMSAL in urine were measured by a two-phase chromatographic approach. Furthermore, individual TIQ concentrations in TS patients were used in receiver-operating characteristics (ROC) curve analysis to examine the diagnostic value. NSAL concentrations were elevated significantly in TS [434.67 ± 55.4 nmol/l (standard error of mean = S.E.M.), two-way ANOVA,
p
< 0.0001] and TS + ADHD patients [605.18 ± 170.21 nmol/l (S.E.M.), two-way ANOVA,
p
< 0.0001] compared with controls [107.02 ± 33.18 nmol/l (S.E.M.), two-way ANOVA,
p
< 0.0001] and NSAL levels in TS + ADHD patients were elevated significantly in comparison with TS patients (two-way ANOVA,
p
= 0.017). NSAL demonstrated an AUC of 0.93 ± 0.046 (S.E.M) the highest diagnostic value of all metabolites for the diagnosis of TS. Our results suggest a dopaminergic hyperactivity underlying the pathophysiology of TS and ADHD. In addition, NSAL concentrations in urine may be a potential diagnostic biomarker of TS.</description><subject>Attention Deficit Disorder with Hyperactivity</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Psychiatry</subject><subject>Psychiatry and Preclinical Psychiatric Studies - Original</subject><subject>Psychiatry and Preclinical Psychiatric Studies - Original Article</subject><subject>Tetrahydroisoquinolines</subject><subject>Tic Disorders</subject><subject>Tourette Syndrome</subject><issn>0300-9564</issn><issn>1435-1463</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9UU1v1DAQtRCIbgt_gAPykUuKJ3bshAOoqviSKnEpZ8ubTHZdJXawvYty46czsKWCCwfbI703b8bvMfYCxCUIYV5nukRdiVrQqduu0o_YBpRsKlBaPmYbIYWoukarM3ae850QAsC0T9mZlLJpdAcb9uNqKphw4Ifkg0srL1iS269Dij7Hbwcf4uQD8gGTP7rij5i5D3yhEkPJ_Lsve34bDwlLQZ7XQI0zvuEJxwn74mPgceRDXNxMMmnne75fF0yOsKMv67tn7MnopozP798L9vXD-9vrT9XNl4-fr69uql4pXSozqqZrjBpAmcE0EltA15pamF4LGFroRrk1TgMxJBipNIxtraGGequ2iPKCvT3pLoftjENP2yc32SX5mb5to_P2XyT4vd3FozUtNI0RJPDqXiCRL5iLnX3ucZpcwHjItlY0FYTWQNT6RO1TzJmseBgDwv6Kzp6isxSd_R2d1dT08u8FH1r-ZEUEeSJkgsIOk70j3wOZ9j_Zn98cqK0</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Capetian, Philipp</creator><creator>Roessner, Veit</creator><creator>Korte, Caroline</creator><creator>Walitza, Susanne</creator><creator>Riederer, Franz</creator><creator>Taurines, Regina</creator><creator>Gerlach, Manfred</creator><creator>Moser, Andreas</creator><general>Springer Vienna</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1712-3659</orcidid></search><sort><creationdate>20210101</creationdate><title>Altered urinary tetrahydroisoquinoline derivatives in patients with Tourette syndrome: reflection of dopaminergic hyperactivity?</title><author>Capetian, Philipp ; Roessner, Veit ; Korte, Caroline ; Walitza, Susanne ; Riederer, Franz ; Taurines, Regina ; Gerlach, Manfred ; Moser, Andreas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-7f459574d147d753e81ea87207c601d819f3b7a614d13173461f8261212b4bee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Attention Deficit Disorder with Hyperactivity</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Psychiatry</topic><topic>Psychiatry and Preclinical Psychiatric Studies - Original</topic><topic>Psychiatry and Preclinical Psychiatric Studies - Original Article</topic><topic>Tetrahydroisoquinolines</topic><topic>Tic Disorders</topic><topic>Tourette Syndrome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Capetian, Philipp</creatorcontrib><creatorcontrib>Roessner, Veit</creatorcontrib><creatorcontrib>Korte, Caroline</creatorcontrib><creatorcontrib>Walitza, Susanne</creatorcontrib><creatorcontrib>Riederer, Franz</creatorcontrib><creatorcontrib>Taurines, Regina</creatorcontrib><creatorcontrib>Gerlach, Manfred</creatorcontrib><creatorcontrib>Moser, Andreas</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Neural Transmission</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Capetian, Philipp</au><au>Roessner, Veit</au><au>Korte, Caroline</au><au>Walitza, Susanne</au><au>Riederer, Franz</au><au>Taurines, Regina</au><au>Gerlach, Manfred</au><au>Moser, Andreas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Altered urinary tetrahydroisoquinoline derivatives in patients with Tourette syndrome: reflection of dopaminergic hyperactivity?</atitle><jtitle>Journal of Neural Transmission</jtitle><stitle>J Neural Transm</stitle><addtitle>J Neural Transm (Vienna)</addtitle><date>2021-01-01</date><risdate>2021</risdate><volume>128</volume><issue>1</issue><spage>115</spage><epage>120</epage><pages>115-120</pages><issn>0300-9564</issn><eissn>1435-1463</eissn><abstract>Tetrahydroisoquinolines (TIQs) such as salsolinol (SAL), norsalsolinol (NSAL) and their methylated derivatives N-methyl-norsalsolinol (NMNSAL) and
N
-methyl-salsolinol (NMSAL), modulate dopaminergic neurotransmission and metabolism in the central nervous system. Dopaminergic neurotransmission is thought to play an important role in the pathophysiology of chronic tic disorders, such as Tourette syndrome (TS). Therefore, the urinary concentrations of these TIQ derivatives were measured in patients with TS and patients with comorbid attention-deficit/hyperactivity disorder (TS + ADHD) compared with controls. Seventeen patients with TS, 12 with TS and ADHD, and 19 age-matched healthy controls with no medication took part in this study. Free levels of NSAL, NMNSAL, SAL, and NMSAL in urine were measured by a two-phase chromatographic approach. Furthermore, individual TIQ concentrations in TS patients were used in receiver-operating characteristics (ROC) curve analysis to examine the diagnostic value. NSAL concentrations were elevated significantly in TS [434.67 ± 55.4 nmol/l (standard error of mean = S.E.M.), two-way ANOVA,
p
< 0.0001] and TS + ADHD patients [605.18 ± 170.21 nmol/l (S.E.M.), two-way ANOVA,
p
< 0.0001] compared with controls [107.02 ± 33.18 nmol/l (S.E.M.), two-way ANOVA,
p
< 0.0001] and NSAL levels in TS + ADHD patients were elevated significantly in comparison with TS patients (two-way ANOVA,
p
= 0.017). NSAL demonstrated an AUC of 0.93 ± 0.046 (S.E.M) the highest diagnostic value of all metabolites for the diagnosis of TS. Our results suggest a dopaminergic hyperactivity underlying the pathophysiology of TS and ADHD. In addition, NSAL concentrations in urine may be a potential diagnostic biomarker of TS.</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><pmid>33355691</pmid><doi>10.1007/s00702-020-02289-6</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-1712-3659</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Attention Deficit Disorder with Hyperactivity Humans Medicine Medicine & Public Health Neurology Neurosciences Psychiatry Psychiatry and Preclinical Psychiatric Studies - Original Psychiatry and Preclinical Psychiatric Studies - Original Article Tetrahydroisoquinolines Tic Disorders Tourette Syndrome |
| title | Altered urinary tetrahydroisoquinoline derivatives in patients with Tourette syndrome: reflection of dopaminergic hyperactivity? |
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