The effect of anesthetics on toll like receptor 9

Toll like receptors (TLRs) are critical receptors to respond to danger signals, and their functions are relevant in the perioperative period. We previously reported that volatile anesthetics directly bound to TLR2 and TLR4 and attenuated their functions. Given that TLR9 can respond to mitochondrial...

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Veröffentlicht in:	The FASEB journal 2020-11, Vol.34 (11), p.14645-14654
Hauptverfasser:	Koutsogiannaki, Sophia, Bu, Weiming, Hou, Lifei, Shibamura‐Fujiogi, Miho, Ishida, Hanako, Ohto, Umeharu, Eckenhoff, Roderic G., Yuki, Koichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthetics, Inhalation - chemistry Anesthetics, Inhalation - pharmacology Animals Binding Sites electrostatic potential HEK293 Cells Horses Humans Isoflurane - chemistry Isoflurane - pharmacology Mice Molecular Docking Simulation nucleic acid Protein Binding Protein Multimerization Sevoflurane - chemistry Sevoflurane - pharmacology Toll-Like Receptor 9 - chemistry Toll-Like Receptor 9 - metabolism toll‐like receptor volatile anesthetics
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