Perinatal SSRI exposure affects brain functional activity associated with whisker stimulation in adolescent and adult rats

Selective serotonin reuptake inhibitors (SSRI), such as fluoxetine, are used as first-line antidepressant medication during pregnancy. Since SSRIs cross the placenta the unborn child is exposed to the maternal SSRI medication, resulting in, amongst others, increased risk for autism in offspring. Thi...

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Veröffentlicht in:	Scientific reports 2021-01, Vol.11 (1), p.1680-9, Article 1680
Hauptverfasser:	Van der Knaap, Noortje, Wiedermann, Dirk, Schubert, Dirk, Hoehn, Mathias, Homberg, Judith R.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/2571 631/378/2620 Adolescents Animals Antidepressants Antidepressive Agents - toxicity Autism Brain - diagnostic imaging Brain - drug effects Brain - metabolism Brain - pathology Brain mapping Cortex (entorhinal) Disease Models, Animal Female Fluoxetine Fluoxetine - toxicity Functional magnetic resonance imaging Genetic crosses Hippocampus Hippocampus - diagnostic imaging Hippocampus - drug effects Hippocampus - metabolism Hippocampus - pathology Humanities and Social Sciences Information processing Magnetic Resonance Imaging - methods Male multidisciplinary Neuroimaging Offspring Perinatal exposure Piriform cortex Placenta Pregnancy Prenatal Exposure Delayed Effects - chemically induced Prenatal Exposure Delayed Effects - pathology Rats Rats, Sprague-Dawley Science Science (multidisciplinary) Selective Serotonin Reuptake Inhibitors - toxicity Sensory integration Serotonin Serotonin - metabolism Serotonin transporter Serotonin uptake inhibitors Somatosensory cortex Thalamus Vibrissae - physiology Visual cortex
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