Prospects for pharmacological targeting of pseudokinases

Pseudokinases are members of the protein kinase superfamily but signal primarily through noncatalytic mechanisms. Many pseudokinases contribute to the pathologies of human diseases, yet they remain largely unexplored as drug targets owing to challenges associated with modulation of their biological...

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Veröffentlicht in:	Nature reviews. Drug discovery 2019-07, Vol.18 (7), p.501-526
Hauptverfasser:	Kung, Jennifer E., Jura, Natalia
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154 631/45/535 631/92/275 Animals Antigens Binding Sites Biomedical and Life Sciences Biomedicine Biotechnology Breast cancer Cancer Research Cancer therapies Drug targeting Forecasts and trends Health aspects Humans Immunoglobulins Kinases Leukemia Ligands Medicinal Chemistry Molecular Conformation Molecular Medicine Molecular Structure Molecular Targeted Therapy Peptides Pharmacology/Toxicology Protein Binding Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology Protein kinases Protein Kinases - chemistry Protein Kinases - genetics Protein Kinases - metabolism Proteins Recruitment Review Article Scholarships & fellowships Small Molecule Libraries - chemistry Small Molecule Libraries - pharmacology Structure
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