Cross-subunit interactions that stabilize open states mediate gating in NMDA receptors

NMDA receptors are excitatory channels with critical functions in the physiology of central synapses. Their activation reaction proceeds as a series of kinetically distinguishable, reversible steps, whose structural bases are currently under investigation. Very likely, the earliest steps include glu...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2021-01, Vol.118 (2), p.1-10
Hauptverfasser:	Iacobucci, Gary J., Wen, Han, Helou, Matthew, Liu, Beiying, Zheng, Wenjun, Popescu, Gabriela K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Biological Sciences Channel gating Charge transfer Glutamic acid receptors (ionotropic) Glycine Helices Humans Kinetics Molecular Dynamics Simulation N-Methyl-D-aspartic acid receptors Receptors Receptors, N-Methyl-D-Aspartate - genetics Receptors, N-Methyl-D-Aspartate - metabolism Synapses
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