Cellular senescence, a novel therapeutic target for mesenchymal stem cells in acute kidney injury
Cellular senescence is a widespread cellular programme that is characterized by permanent cell cycle arrest. Senescent cells adopt a changed secretory phenotype that can alter cellular function. For years, cellular senescence has been thought to be a protective factor against cancer; however, it is...
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| Veröffentlicht in: | Journal of cellular and molecular medicine 2021-01, Vol.25 (2), p.629-638 |
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| creator | Zhao, Lingfei Hu, Chenxia Han, Fei Chen, Dajin Ma, Yanhong Wang, Junni Chen, Jianghua |
| description | Cellular senescence is a widespread cellular programme that is characterized by permanent cell cycle arrest. Senescent cells adopt a changed secretory phenotype that can alter cellular function. For years, cellular senescence has been thought to be a protective factor against cancer; however, it is now recognized that it has a dual effect on individuals. Co‐ordinated activation of cellular senescence provides advantages during embryogenesis, wound healing, tissue repair and inhibition of tumorigenesis. On the other hand, the aberrant generation and accumulation of abnormal senescent cells lead to the development of age‐related conditions and tissue deterioration. During acute kidney injury (AKI), the kidney faces multiple types of stressors and challenges, which can easily drive cellular senescence. How to appropriately progress through the cell cycle and minimize long‐term damage is of great importance to the acquisition of adaptive repair considering that no available therapeutic interventions can reliably limit injury, speedy recovery or improve the prognosis of this syndrome. Whether the manipulation of cellular senescence can become a novel therapeutic target in AKI and reignite clinical and research interest remains to be determined. Here, we share our current understanding of the role of cellular senescence in AKI, along with examples of the application of mesenchymal stem cells (MSCs) for targeting this disorder during its treatment. |
| doi_str_mv | 10.1111/jcmm.16163 |
| format | Article |
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Senescent cells adopt a changed secretory phenotype that can alter cellular function. For years, cellular senescence has been thought to be a protective factor against cancer; however, it is now recognized that it has a dual effect on individuals. Co‐ordinated activation of cellular senescence provides advantages during embryogenesis, wound healing, tissue repair and inhibition of tumorigenesis. On the other hand, the aberrant generation and accumulation of abnormal senescent cells lead to the development of age‐related conditions and tissue deterioration. During acute kidney injury (AKI), the kidney faces multiple types of stressors and challenges, which can easily drive cellular senescence. How to appropriately progress through the cell cycle and minimize long‐term damage is of great importance to the acquisition of adaptive repair considering that no available therapeutic interventions can reliably limit injury, speedy recovery or improve the prognosis of this syndrome. Whether the manipulation of cellular senescence can become a novel therapeutic target in AKI and reignite clinical and research interest remains to be determined. Here, we share our current understanding of the role of cellular senescence in AKI, along with examples of the application of mesenchymal stem cells (MSCs) for targeting this disorder during its treatment.</description><identifier>ISSN: 1582-1838</identifier><identifier>EISSN: 1582-4934</identifier><identifier>DOI: 10.1111/jcmm.16163</identifier><language>eng</language><publisher>Chichester: John Wiley & Sons, Inc</publisher><subject>acute kidney injury ; Age ; Apoptosis ; Cell culture ; Cell cycle ; Cell division ; cellular senescence ; Cyclin-dependent kinases ; Embryogenesis ; Gene expression ; Health care ; Heart surgery ; Ischemia ; Kidney diseases ; Kidneys ; Kinases ; Mesenchymal stem cells ; Mortality ; Phenotypes ; Proteins ; Review ; Reviews ; Senescence ; Stem cells ; Therapeutic applications ; Therapeutic targets ; Tissue engineering ; Tumorigenesis ; Wound healing</subject><ispartof>Journal of cellular and molecular medicine, 2021-01, Vol.25 (2), p.629-638</ispartof><rights>2020 The Authors. published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.</rights><rights>2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4203-b76397b816b9c03b3fcd88787084c425518be7addfd74b9e62c01c50ec4c3e323</citedby><cites>FETCH-LOGICAL-c4203-b76397b816b9c03b3fcd88787084c425518be7addfd74b9e62c01c50ec4c3e323</cites><orcidid>0000-0002-1805-0589</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812305/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812305/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1411,11542,27903,27904,45553,45554,46031,46455,53770,53772</link.rule.ids></links><search><creatorcontrib>Zhao, Lingfei</creatorcontrib><creatorcontrib>Hu, Chenxia</creatorcontrib><creatorcontrib>Han, Fei</creatorcontrib><creatorcontrib>Chen, Dajin</creatorcontrib><creatorcontrib>Ma, Yanhong</creatorcontrib><creatorcontrib>Wang, Junni</creatorcontrib><creatorcontrib>Chen, Jianghua</creatorcontrib><title>Cellular senescence, a novel therapeutic target for mesenchymal stem cells in acute kidney injury</title><title>Journal of cellular and molecular medicine</title><description>Cellular senescence is a widespread cellular programme that is characterized by permanent cell cycle arrest. Senescent cells adopt a changed secretory phenotype that can alter cellular function. For years, cellular senescence has been thought to be a protective factor against cancer; however, it is now recognized that it has a dual effect on individuals. Co‐ordinated activation of cellular senescence provides advantages during embryogenesis, wound healing, tissue repair and inhibition of tumorigenesis. On the other hand, the aberrant generation and accumulation of abnormal senescent cells lead to the development of age‐related conditions and tissue deterioration. During acute kidney injury (AKI), the kidney faces multiple types of stressors and challenges, which can easily drive cellular senescence. How to appropriately progress through the cell cycle and minimize long‐term damage is of great importance to the acquisition of adaptive repair considering that no available therapeutic interventions can reliably limit injury, speedy recovery or improve the prognosis of this syndrome. Whether the manipulation of cellular senescence can become a novel therapeutic target in AKI and reignite clinical and research interest remains to be determined. Here, we share our current understanding of the role of cellular senescence in AKI, along with examples of the application of mesenchymal stem cells (MSCs) for targeting this disorder during its treatment.</description><subject>acute kidney injury</subject><subject>Age</subject><subject>Apoptosis</subject><subject>Cell culture</subject><subject>Cell cycle</subject><subject>Cell division</subject><subject>cellular senescence</subject><subject>Cyclin-dependent kinases</subject><subject>Embryogenesis</subject><subject>Gene expression</subject><subject>Health care</subject><subject>Heart surgery</subject><subject>Ischemia</subject><subject>Kidney diseases</subject><subject>Kidneys</subject><subject>Kinases</subject><subject>Mesenchymal stem cells</subject><subject>Mortality</subject><subject>Phenotypes</subject><subject>Proteins</subject><subject>Review</subject><subject>Reviews</subject><subject>Senescence</subject><subject>Stem cells</subject><subject>Therapeutic applications</subject><subject>Therapeutic targets</subject><subject>Tissue engineering</subject><subject>Tumorigenesis</subject><subject>Wound healing</subject><issn>1582-1838</issn><issn>1582-4934</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU1PwzAMhiMEEmNw4RdE4oboSJq0SS9IaOJTm7jAOUpTd2vpx0jaof57MjohcVkujuXHr2y_CF1SMqP-3Zamrmc0pjE7QhMayTDgCePH-z-VTJ6iM-dKQlhMWTJBeg5V1VfaYgcNOAONgRuscdNuocLdGqzeQN8VBnfarqDDeWtxDR4266HWFXYd1Nh4EYeLBmvTd4A_i6yBwedlb4dzdJLrysHFPk7Rx-PD-_w5WLw9vczvF4HhIWFBKmKWiFTSOE0MYSnLTSalkIJI7okoojIFobMszwRPE4hDQ6iJCBhuGLCQTdHdqLvp0xoyv0lndaU2tqi1HVSrC_W_0hRrtWq3SkgaMhJ5gau9gG2_enCdKtveNn5mxYiMRZKEcXiICrmQnHLuLztF1yNlbOuchfxvDkrUzim1c0r9OuVhOsLfRQXDAVK9zpfLsecHb0KXcw</recordid><startdate>202101</startdate><enddate>202101</enddate><creator>Zhao, Lingfei</creator><creator>Hu, Chenxia</creator><creator>Han, Fei</creator><creator>Chen, Dajin</creator><creator>Ma, Yanhong</creator><creator>Wang, Junni</creator><creator>Chen, Jianghua</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1805-0589</orcidid></search><sort><creationdate>202101</creationdate><title>Cellular senescence, a novel therapeutic target for mesenchymal stem cells in acute kidney injury</title><author>Zhao, Lingfei ; 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| subjects | acute kidney injury Age Apoptosis Cell culture Cell cycle Cell division cellular senescence Cyclin-dependent kinases Embryogenesis Gene expression Health care Heart surgery Ischemia Kidney diseases Kidneys Kinases Mesenchymal stem cells Mortality Phenotypes Proteins Review Reviews Senescence Stem cells Therapeutic applications Therapeutic targets Tissue engineering Tumorigenesis Wound healing |
| title | Cellular senescence, a novel therapeutic target for mesenchymal stem cells in acute kidney injury |
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