Evaluation of piggyBac‐mediated anti‐CD19 CAR‐T cells after ex vivo expansion with aAPCs or magnetic beads

Adoptive immunotherapy is a new potential method of tumour therapy, among which anti‐CD19 chimeric antigen receptor T‐cell therapy (CAR‐T cell), is a typical treatment agent for haematological malignancies. Previous clinical trials showed that the quality and phenotype of CAR‐T cells expanded ex viv...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2021-01, Vol.25 (2), p.686-700
Hauptverfasser:	Yang, Li‐Rong, Li, Lin, Meng, Ming‐Yao, Wang, Wen‐Ju, Yang, Song‐Lin, Zhao, Yi‐Yi, Wang, Run‐Qing, Gao, Hui, Tang, Wei‐Wei, Yang, Yang, Yang, Li‐Li, Liao, Li‐Wei, Hou, Zong‐Liu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive immunotherapy Antigens Apoptosis artificial antigen‐presenting cells CAR‐T cells CD19 CD19 antigen CD28 antigen CD3 antigen CD86 antigen Cell therapy Cells Chimeric antigen receptors Clinical trials Cloning Cytokines Cytotoxicity Deoxyribonucleic acid DNA FDA approval Flow cytometry Foot & mouth disease Genes Immunological memory Immunotherapy Ligands Lymphocytes Lymphocytes T Malignancy Medical research Memory cells Monoclonal antibodies Original Penicillin Phenotypes piggyBac Tumors Xenografts
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