Multiple screening approaches reveal HDAC6 as a novel regulator of glycolytic metabolism in triple-negative breast cancer

Triple-negative breast cancer (TNBC) is a subtype of breast cancer without a targeted form of therapy. Unfortunately, up to 70% of patients with TNBC develop resistance to treatment. A known contributor to chemoresistance is dysfunctional mitochondrial apoptosis signaling. We set up a phenotypic sma...

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Veröffentlicht in:	Science advances 2021-01, Vol.7 (3)
Hauptverfasser:	Dowling, Catríona M, Hollinshead, Kate E R, Di Grande, Alessandra, Pritchard, Justin, Zhang, Hua, Dillon, Eugene T, Haley, Kathryn, Papadopoulos, Eleni, Mehta, Anita K, Bleach, Rachel, Lindner, Andreas U, Mooney, Brian, Düssmann, Heiko, O'Connor, Darran, Prehn, Jochen H M, Wynne, Kieran, Hemann, Michael, Bradner, James E, Kimmelman, Alec C, Guerriero, Jennifer L, Cagney, Gerard, Wong, Kwok-Kin, Letai, Anthony G, Chonghaile, Tríona Ní
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Cell Biology SciAdv r-articles
Online-Zugang:	Volltext
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