An Update on the Role of Common Genetic Variation Underlying Substance Use Disorders
Purpose of the Review Sample size increases have resulted in novel and replicable loci for substance use disorders (SUDs). We summarize some of the latest insights into SUD genetics and discuss next steps for the field. Recent Findings Genome-wide association studies have substantiated the role of p...
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| Veröffentlicht in: | Current genetic medicine reports 2020-06, Vol.8 (2), p.35-46 |
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| creator | Johnson, Emma C. Chang, Yoonhoo Agrawal, Arpana |
| description | Purpose of the Review
Sample size increases have resulted in novel and replicable loci for substance use disorders (SUDs). We summarize some of the latest insights into SUD genetics and discuss next steps for the field.
Recent Findings
Genome-wide association studies have substantiated the role of previously known variants (e.g., rs1229984 in
ADH1B
for alcohol) and identified several novel loci for alcohol, tobacco, cannabis, opioid, and cocaine use disorders. SUDs are genetically correlated with psychiatric outcomes, while liability to substance use is inconsistently associated with these outcomes and more closely associated with lifestyle factors. Specific variant associations appear to differ somewhat across populations, although similar genes and systems are implicated.
Summary
The next decade of human genetic studies of addiction should focus on expanding to non-European populations, consider pleiotropy across SUDs and with other psychiatric disorders, and leverage human and cross-species functional data to elucidate the biological mechanisms underlying SUDs. |
| doi_str_mv | 10.1007/s40142-020-00184-w |
| format | Article |
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Sample size increases have resulted in novel and replicable loci for substance use disorders (SUDs). We summarize some of the latest insights into SUD genetics and discuss next steps for the field.
Recent Findings
Genome-wide association studies have substantiated the role of previously known variants (e.g., rs1229984 in
ADH1B
for alcohol) and identified several novel loci for alcohol, tobacco, cannabis, opioid, and cocaine use disorders. SUDs are genetically correlated with psychiatric outcomes, while liability to substance use is inconsistently associated with these outcomes and more closely associated with lifestyle factors. Specific variant associations appear to differ somewhat across populations, although similar genes and systems are implicated.
Summary
The next decade of human genetic studies of addiction should focus on expanding to non-European populations, consider pleiotropy across SUDs and with other psychiatric disorders, and leverage human and cross-species functional data to elucidate the biological mechanisms underlying SUDs.</description><identifier>ISSN: 2167-4876</identifier><identifier>EISSN: 2167-4876</identifier><identifier>DOI: 10.1007/s40142-020-00184-w</identifier><identifier>PMID: 33457110</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Addictions ; Alcohol dehydrogenase ; Cannabis ; Cocaine ; Drug use ; Genetic diversity ; Genome-wide association studies ; Genomes ; Internal Medicine ; Medicine ; Medicine & Public Health ; Mental disorders ; Neurogenetics and Psychiatric Genetics ; Neurogenetics and Psychiatric Genetics (C Cruchaga and C Karch ; Opioids ; Pleiotropy ; Section Editors ; Tobacco</subject><ispartof>Current genetic medicine reports, 2020-06, Vol.8 (2), p.35-46</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-7bc7f82b38e2264aeedf46e48bc587d44193e9ffb51c19dc406d74386f9992c23</citedby><cites>FETCH-LOGICAL-c404t-7bc7f82b38e2264aeedf46e48bc587d44193e9ffb51c19dc406d74386f9992c23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40142-020-00184-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40142-020-00184-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33457110$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Johnson, Emma C.</creatorcontrib><creatorcontrib>Chang, Yoonhoo</creatorcontrib><creatorcontrib>Agrawal, Arpana</creatorcontrib><title>An Update on the Role of Common Genetic Variation Underlying Substance Use Disorders</title><title>Current genetic medicine reports</title><addtitle>Curr Genet Med Rep</addtitle><addtitle>Curr Genet Med Rep</addtitle><description>Purpose of the Review
Sample size increases have resulted in novel and replicable loci for substance use disorders (SUDs). We summarize some of the latest insights into SUD genetics and discuss next steps for the field.
Recent Findings
Genome-wide association studies have substantiated the role of previously known variants (e.g., rs1229984 in
ADH1B
for alcohol) and identified several novel loci for alcohol, tobacco, cannabis, opioid, and cocaine use disorders. SUDs are genetically correlated with psychiatric outcomes, while liability to substance use is inconsistently associated with these outcomes and more closely associated with lifestyle factors. Specific variant associations appear to differ somewhat across populations, although similar genes and systems are implicated.
Summary
The next decade of human genetic studies of addiction should focus on expanding to non-European populations, consider pleiotropy across SUDs and with other psychiatric disorders, and leverage human and cross-species functional data to elucidate the biological mechanisms underlying SUDs.</description><subject>Addictions</subject><subject>Alcohol dehydrogenase</subject><subject>Cannabis</subject><subject>Cocaine</subject><subject>Drug use</subject><subject>Genetic diversity</subject><subject>Genome-wide association studies</subject><subject>Genomes</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mental disorders</subject><subject>Neurogenetics and Psychiatric Genetics</subject><subject>Neurogenetics and Psychiatric Genetics (C Cruchaga and C Karch</subject><subject>Opioids</subject><subject>Pleiotropy</subject><subject>Section Editors</subject><subject>Tobacco</subject><issn>2167-4876</issn><issn>2167-4876</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kV1rFTEQhoMottT-AS8k4I03W_N1NsmNUE61CgVBe7wN2ezsacpuckx2Lf33Tj21Vi8MhAwzz7yT5CXkJWcnnDH9tirGlWiYYA1j3Kjm5gk5FLzVjTK6ffooPiDHtV4zXEa0uJ-TAynVSnPODsnlaaKbXe9noDnR-QrolzxiPNB1niZMnUOCOQb6zZfo54iZTeqhjLcxbenXpauzTwHopgI9izUXrNUX5NngxwrH9-cR2Xx4f7n-2Fx8Pv-0Pr1ogmJqbnQX9GBEJw0I0SoP0A-qBWW6sDK6V4pbCXYYuhUP3PbY1PZaSdMO1loRhDwi7_a6u6WboA-Q5uJHtytx8uXWZR_d35UUr9w2_3DacPw4iQJv7gVK_r5And0Ua4Bx9AnyUp1Q2mgtrDKIvv4Hvc5LSfg8J6S1kiO5QkrsqVByrQWGh8tw5u58c3vfHI53v3xzN9j06vEzHlp-u4SA3AMVS2kL5c_s_8j-BMDio38</recordid><startdate>20200601</startdate><enddate>20200601</enddate><creator>Johnson, Emma C.</creator><creator>Chang, Yoonhoo</creator><creator>Agrawal, Arpana</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200601</creationdate><title>An Update on the Role of Common Genetic Variation Underlying Substance Use Disorders</title><author>Johnson, Emma C. ; Chang, Yoonhoo ; Agrawal, Arpana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-7bc7f82b38e2264aeedf46e48bc587d44193e9ffb51c19dc406d74386f9992c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Addictions</topic><topic>Alcohol dehydrogenase</topic><topic>Cannabis</topic><topic>Cocaine</topic><topic>Drug use</topic><topic>Genetic diversity</topic><topic>Genome-wide association studies</topic><topic>Genomes</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mental disorders</topic><topic>Neurogenetics and Psychiatric Genetics</topic><topic>Neurogenetics and Psychiatric Genetics (C Cruchaga and C Karch</topic><topic>Opioids</topic><topic>Pleiotropy</topic><topic>Section Editors</topic><topic>Tobacco</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Johnson, Emma C.</creatorcontrib><creatorcontrib>Chang, Yoonhoo</creatorcontrib><creatorcontrib>Agrawal, Arpana</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Current genetic medicine reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Johnson, Emma C.</au><au>Chang, Yoonhoo</au><au>Agrawal, Arpana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An Update on the Role of Common Genetic Variation Underlying Substance Use Disorders</atitle><jtitle>Current genetic medicine reports</jtitle><stitle>Curr Genet Med Rep</stitle><addtitle>Curr Genet Med Rep</addtitle><date>2020-06-01</date><risdate>2020</risdate><volume>8</volume><issue>2</issue><spage>35</spage><epage>46</epage><pages>35-46</pages><issn>2167-4876</issn><eissn>2167-4876</eissn><abstract>Purpose of the Review
Sample size increases have resulted in novel and replicable loci for substance use disorders (SUDs). We summarize some of the latest insights into SUD genetics and discuss next steps for the field.
Recent Findings
Genome-wide association studies have substantiated the role of previously known variants (e.g., rs1229984 in
ADH1B
for alcohol) and identified several novel loci for alcohol, tobacco, cannabis, opioid, and cocaine use disorders. SUDs are genetically correlated with psychiatric outcomes, while liability to substance use is inconsistently associated with these outcomes and more closely associated with lifestyle factors. Specific variant associations appear to differ somewhat across populations, although similar genes and systems are implicated.
Summary
The next decade of human genetic studies of addiction should focus on expanding to non-European populations, consider pleiotropy across SUDs and with other psychiatric disorders, and leverage human and cross-species functional data to elucidate the biological mechanisms underlying SUDs.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>33457110</pmid><doi>10.1007/s40142-020-00184-w</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Addictions Alcohol dehydrogenase Cannabis Cocaine Drug use Genetic diversity Genome-wide association studies Genomes Internal Medicine Medicine Medicine & Public Health Mental disorders Neurogenetics and Psychiatric Genetics Neurogenetics and Psychiatric Genetics (C Cruchaga and C Karch Opioids Pleiotropy Section Editors Tobacco |
| title | An Update on the Role of Common Genetic Variation Underlying Substance Use Disorders |
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