A microtubule‐LUZP1 association around tight junction promotes epithelial cell apical constriction

Apical constriction is critical for epithelial morphogenesis, including neural tube formation. Vertebrate apical constriction is induced by di‐phosphorylated myosin light chain (ppMLC)‐driven contraction of actomyosin‐based circumferential rings (CRs), also known as perijunctional actomyosin rings,...

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Veröffentlicht in:	The EMBO journal 2021-01, Vol.40 (2), p.e104712-n/a
Hauptverfasser:	Yano, Tomoki, Tsukita, Kazuto, Kanoh, Hatsuho, Nakayama, Shogo, Kashihara, Hiroka, Mizuno, Tomoaki, Tanaka, Hiroo, Matsui, Takeshi, Goto, Yuhei, Komatsubara, Akira, Aoki, Kazuhiro, Takahashi, Ryosuke, Tamura, Atsushi, Tsukita, Sachiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Cytoskeleton - metabolism Actins - metabolism Actomyosin actomyosin‐based circumferential rings Adherens junctions Adherens Junctions - metabolism Animals apical constriction apical microtubules Cell Line Chains Chickens Constrictions Contraction DNA-Binding Proteins - metabolism EMBO05 EMBO31 Epithelial cells Epithelial Cells - metabolism HEK293 Cells Humans Kinases Leucine Leucine zipper proteins LUZP1 Mice Mice, Inbred C57BL Microtubules Microtubules - metabolism Morphogenesis Myosin Myosins - metabolism Neural tube Phosphatase Phosphorylation Proteins Recruitment Sf9 Cells tight junction Tight junctions Tight Junctions - metabolism Vertebrates
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