A negative-feedback loop maintains optimal chemokine concentrations for directional cell migration

Chemoattractant gradients frequently guide migrating cells. To achieve the most directional signal, such gradients should be maintained with concentrations around the dissociation constant ( K d ) 1 – 6 of the chemoreceptor. Whether this actually occurs in animals is unknown. Here we investigate whe...

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Veröffentlicht in:	Nature cell biology 2020-03, Vol.22 (3), p.266-273
Hauptverfasser:	Lau, Stephanie, Feitzinger, Anna, Venkiteswaran, Gayatri, Wang, John, Lewellis, Stephen W., Koplinski, Chad A., Peterson, Francis C., Volkman, Brian F., Meier-Schellersheim, Martin, Knaut, Holger
Format:	Artikel
Sprache:	eng
Schlagworte:	14 14/35 631/136 631/80/84/1372 631/80/84/2334 631/80/86/820 64 64/116 Animals Animals, Genetically Modified Biomedical and Life Sciences Buffers Cancer Research Cell adhesion & migration Cell Biology Cell Line Cell migration Cell Movement Chemokine CXCL12 - metabolism Chemokines Chemokines - metabolism CXCL12 protein CXCR4 protein Danio rerio Developmental Biology Embryonic development Embryos Feedback Feedback loops Feedback, Physiological Health aspects Humans Lateral line Letter Life Sciences Negative feedback Phosphorylation Receptors, CXCR - metabolism Receptors, CXCR4 - metabolism Robustness SDF-1 protein Stem Cells Zebrafish Zebrafish - embryology Zebrafish - genetics Zebrafish - metabolism Zebrafish Proteins - metabolism
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