The Effect of Exercise During Pregnancy on Maternal and Offspring Vascular Outcomes: a Pilot Study

The aim of this pilot study is to obtain estimates for the change in maternal cerebrovascular (primary) and offspring vascular structure (secondary) during healthy pregnancy that includes structured exercise. Eighteen pregnant women self-assigned to a moderate-intensity aerobic exercise intervention...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Reproductive sciences (Thousand Oaks, Calif.) Calif.), 2021-02, Vol.28 (2), p.510-523
Hauptverfasser: Brislane, Áine, Jones, Helen, Holder, Sophie M., Low, David A., Hopkins, Nicola D.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 523
container_issue 2
container_start_page 510
container_title Reproductive sciences (Thousand Oaks, Calif.)
container_volume 28
creator Brislane, Áine
Jones, Helen
Holder, Sophie M.
Low, David A.
Hopkins, Nicola D.
description The aim of this pilot study is to obtain estimates for the change in maternal cerebrovascular (primary) and offspring vascular structure (secondary) during healthy pregnancy that includes structured exercise. Eighteen pregnant women self-assigned to a moderate-intensity aerobic exercise intervention or a control group. Maternal cerebral blood flow (CBF) at the middle cerebral artery, cerebro- and peripheral-vascular function was assessed at the end of each trimester. Offspring carotid artery intima-media thickness (IMT) was measured within 12 weeks of birth. For exploratory purposes, we performed statistical analysis to provide estimates of the change for primary and secondary outcome variables. Maternal CBF reduced (− 8 cm s −1 [− 14 to − 2]) with evidence of change to cerebral autoregulation (normalised gain: 0.12 %cm s −1 % mmHg −1 mmHg/% [− 0.18 to 0.40]) during pregnancy. Offspring carotid IMT was smaller in the exercise group (− 0.04 mm [− 0.12–0.03]) compared with controls. Based upon this data, a sample size of 33 and 57 in each group is required for low-frequency normalised gain and offspring IMT, respectively. This would provide 90% power to detect statistically significant ( P  
doi_str_mv 10.1007/s43032-020-00302-7
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7808996</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2466035469</sourcerecordid><originalsourceid>FETCH-LOGICAL-c446t-f62371f770bd246a951141985e4c8b08c4f973e890f56ce41222dd5dbbeace6f3</originalsourceid><addsrcrecordid>eNp9kU1PFTEUhhujEUT_gAvTpZvB049ppy5MDFyUBHNJBLZNp3N6GTK3xXbGeP89AwNEN67apM95--Y8hLxncMgA9KciBQheAYcKQACv9Auyz4wQleZQv3y6M8P2yJtSbgBqaXjzmuwJwesGlNwn7cU10lUI6EeaAl39wez7gvR4yn3c0POMm-ii39EU6Q83Yo5uoC52dB1CuX1grlzx0-AyXU-jT1ssn6mj5_2QRvpznLrdW_IquKHgu8fzgFyerC6Ovldn62-nR1_PKi-lGquguNAsaA1tx6VypmZMMtPUKH3TQuNlMFpgYyDUyqNknPOuq7u2RedRBXFAviy5t1O7xc5jHLMb7Fxy6_LOJtfbf19if2036bfVDTTGqDng42NATr8mLKPd9sXjMLiIaSp2bqVA1FKZGeUL6nMqJWN4_oaBvZdjFzl2lmMf5Fg9D334u-DzyJONGRALsGwWs71J0_3Gy_9i7wCNU5tW</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2466035469</pqid></control><display><type>article</type><title>The Effect of Exercise During Pregnancy on Maternal and Offspring Vascular Outcomes: a Pilot Study</title><source>SpringerLink_现刊</source><source>Alma/SFX Local Collection</source><creator>Brislane, Áine ; Jones, Helen ; Holder, Sophie M. ; Low, David A. ; Hopkins, Nicola D.</creator><creatorcontrib>Brislane, Áine ; Jones, Helen ; Holder, Sophie M. ; Low, David A. ; Hopkins, Nicola D.</creatorcontrib><description>The aim of this pilot study is to obtain estimates for the change in maternal cerebrovascular (primary) and offspring vascular structure (secondary) during healthy pregnancy that includes structured exercise. Eighteen pregnant women self-assigned to a moderate-intensity aerobic exercise intervention or a control group. Maternal cerebral blood flow (CBF) at the middle cerebral artery, cerebro- and peripheral-vascular function was assessed at the end of each trimester. Offspring carotid artery intima-media thickness (IMT) was measured within 12 weeks of birth. For exploratory purposes, we performed statistical analysis to provide estimates of the change for primary and secondary outcome variables. Maternal CBF reduced (− 8 cm s −1 [− 14 to − 2]) with evidence of change to cerebral autoregulation (normalised gain: 0.12 %cm s −1 % mmHg −1 mmHg/% [− 0.18 to 0.40]) during pregnancy. Offspring carotid IMT was smaller in the exercise group (− 0.04 mm [− 0.12–0.03]) compared with controls. Based upon this data, a sample size of 33 and 57 in each group is required for low-frequency normalised gain and offspring IMT, respectively. This would provide 90% power to detect statistically significant ( P  &lt; 0.05) between group differences in a randomised controlled trial. CBF is reduced in pregnancy, possibly due to reduced vascular resistance and altered maternal cerebral autoregulation. Maternal exercise had negligible effects on cerebrovascular adaptation to pregnancy, but we observed lower offspring carotid artery wall thickness following maternal exercise. Our directional findings and sample size estimations should be explored in a fully powered randomised control trial. Clinical trial registration: The trial was registered on March 14th at https://register.clinicaltrials.gov (NCT03079258). Participant enrolment began on 3rd April 2016.</description><identifier>ISSN: 1933-7191</identifier><identifier>EISSN: 1933-7205</identifier><identifier>DOI: 10.1007/s43032-020-00302-7</identifier><identifier>PMID: 33258064</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Developmental Programming: Original ; Developmental Programming: Original Article ; Embryology ; Medicine ; Medicine &amp; Public Health ; Obstetrics/Perinatology/Midwifery ; Reproductive Medicine</subject><ispartof>Reproductive sciences (Thousand Oaks, Calif.), 2021-02, Vol.28 (2), p.510-523</ispartof><rights>The Author(s) 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c446t-f62371f770bd246a951141985e4c8b08c4f973e890f56ce41222dd5dbbeace6f3</citedby><cites>FETCH-LOGICAL-c446t-f62371f770bd246a951141985e4c8b08c4f973e890f56ce41222dd5dbbeace6f3</cites><orcidid>0000-0002-3214-6544</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s43032-020-00302-7$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s43032-020-00302-7$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33258064$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brislane, Áine</creatorcontrib><creatorcontrib>Jones, Helen</creatorcontrib><creatorcontrib>Holder, Sophie M.</creatorcontrib><creatorcontrib>Low, David A.</creatorcontrib><creatorcontrib>Hopkins, Nicola D.</creatorcontrib><title>The Effect of Exercise During Pregnancy on Maternal and Offspring Vascular Outcomes: a Pilot Study</title><title>Reproductive sciences (Thousand Oaks, Calif.)</title><addtitle>Reprod. Sci</addtitle><addtitle>Reprod Sci</addtitle><description>The aim of this pilot study is to obtain estimates for the change in maternal cerebrovascular (primary) and offspring vascular structure (secondary) during healthy pregnancy that includes structured exercise. Eighteen pregnant women self-assigned to a moderate-intensity aerobic exercise intervention or a control group. Maternal cerebral blood flow (CBF) at the middle cerebral artery, cerebro- and peripheral-vascular function was assessed at the end of each trimester. Offspring carotid artery intima-media thickness (IMT) was measured within 12 weeks of birth. For exploratory purposes, we performed statistical analysis to provide estimates of the change for primary and secondary outcome variables. Maternal CBF reduced (− 8 cm s −1 [− 14 to − 2]) with evidence of change to cerebral autoregulation (normalised gain: 0.12 %cm s −1 % mmHg −1 mmHg/% [− 0.18 to 0.40]) during pregnancy. Offspring carotid IMT was smaller in the exercise group (− 0.04 mm [− 0.12–0.03]) compared with controls. Based upon this data, a sample size of 33 and 57 in each group is required for low-frequency normalised gain and offspring IMT, respectively. This would provide 90% power to detect statistically significant ( P  &lt; 0.05) between group differences in a randomised controlled trial. CBF is reduced in pregnancy, possibly due to reduced vascular resistance and altered maternal cerebral autoregulation. Maternal exercise had negligible effects on cerebrovascular adaptation to pregnancy, but we observed lower offspring carotid artery wall thickness following maternal exercise. Our directional findings and sample size estimations should be explored in a fully powered randomised control trial. Clinical trial registration: The trial was registered on March 14th at https://register.clinicaltrials.gov (NCT03079258). Participant enrolment began on 3rd April 2016.</description><subject>Developmental Programming: Original</subject><subject>Developmental Programming: Original Article</subject><subject>Embryology</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>Reproductive Medicine</subject><issn>1933-7191</issn><issn>1933-7205</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><recordid>eNp9kU1PFTEUhhujEUT_gAvTpZvB049ppy5MDFyUBHNJBLZNp3N6GTK3xXbGeP89AwNEN67apM95--Y8hLxncMgA9KciBQheAYcKQACv9Auyz4wQleZQv3y6M8P2yJtSbgBqaXjzmuwJwesGlNwn7cU10lUI6EeaAl39wez7gvR4yn3c0POMm-ii39EU6Q83Yo5uoC52dB1CuX1grlzx0-AyXU-jT1ssn6mj5_2QRvpznLrdW_IquKHgu8fzgFyerC6Ovldn62-nR1_PKi-lGquguNAsaA1tx6VypmZMMtPUKH3TQuNlMFpgYyDUyqNknPOuq7u2RedRBXFAviy5t1O7xc5jHLMb7Fxy6_LOJtfbf19if2036bfVDTTGqDng42NATr8mLKPd9sXjMLiIaSp2bqVA1FKZGeUL6nMqJWN4_oaBvZdjFzl2lmMf5Fg9D334u-DzyJONGRALsGwWs71J0_3Gy_9i7wCNU5tW</recordid><startdate>20210201</startdate><enddate>20210201</enddate><creator>Brislane, Áine</creator><creator>Jones, Helen</creator><creator>Holder, Sophie M.</creator><creator>Low, David A.</creator><creator>Hopkins, Nicola D.</creator><general>Springer International Publishing</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3214-6544</orcidid></search><sort><creationdate>20210201</creationdate><title>The Effect of Exercise During Pregnancy on Maternal and Offspring Vascular Outcomes: a Pilot Study</title><author>Brislane, Áine ; Jones, Helen ; Holder, Sophie M. ; Low, David A. ; Hopkins, Nicola D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-f62371f770bd246a951141985e4c8b08c4f973e890f56ce41222dd5dbbeace6f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Developmental Programming: Original</topic><topic>Developmental Programming: Original Article</topic><topic>Embryology</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Obstetrics/Perinatology/Midwifery</topic><topic>Reproductive Medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brislane, Áine</creatorcontrib><creatorcontrib>Jones, Helen</creatorcontrib><creatorcontrib>Holder, Sophie M.</creatorcontrib><creatorcontrib>Low, David A.</creatorcontrib><creatorcontrib>Hopkins, Nicola D.</creatorcontrib><collection>Springer_OA刊</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Reproductive sciences (Thousand Oaks, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brislane, Áine</au><au>Jones, Helen</au><au>Holder, Sophie M.</au><au>Low, David A.</au><au>Hopkins, Nicola D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effect of Exercise During Pregnancy on Maternal and Offspring Vascular Outcomes: a Pilot Study</atitle><jtitle>Reproductive sciences (Thousand Oaks, Calif.)</jtitle><stitle>Reprod. Sci</stitle><addtitle>Reprod Sci</addtitle><date>2021-02-01</date><risdate>2021</risdate><volume>28</volume><issue>2</issue><spage>510</spage><epage>523</epage><pages>510-523</pages><issn>1933-7191</issn><eissn>1933-7205</eissn><abstract>The aim of this pilot study is to obtain estimates for the change in maternal cerebrovascular (primary) and offspring vascular structure (secondary) during healthy pregnancy that includes structured exercise. Eighteen pregnant women self-assigned to a moderate-intensity aerobic exercise intervention or a control group. Maternal cerebral blood flow (CBF) at the middle cerebral artery, cerebro- and peripheral-vascular function was assessed at the end of each trimester. Offspring carotid artery intima-media thickness (IMT) was measured within 12 weeks of birth. For exploratory purposes, we performed statistical analysis to provide estimates of the change for primary and secondary outcome variables. Maternal CBF reduced (− 8 cm s −1 [− 14 to − 2]) with evidence of change to cerebral autoregulation (normalised gain: 0.12 %cm s −1 % mmHg −1 mmHg/% [− 0.18 to 0.40]) during pregnancy. Offspring carotid IMT was smaller in the exercise group (− 0.04 mm [− 0.12–0.03]) compared with controls. Based upon this data, a sample size of 33 and 57 in each group is required for low-frequency normalised gain and offspring IMT, respectively. This would provide 90% power to detect statistically significant ( P  &lt; 0.05) between group differences in a randomised controlled trial. CBF is reduced in pregnancy, possibly due to reduced vascular resistance and altered maternal cerebral autoregulation. Maternal exercise had negligible effects on cerebrovascular adaptation to pregnancy, but we observed lower offspring carotid artery wall thickness following maternal exercise. Our directional findings and sample size estimations should be explored in a fully powered randomised control trial. Clinical trial registration: The trial was registered on March 14th at https://register.clinicaltrials.gov (NCT03079258). Participant enrolment began on 3rd April 2016.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>33258064</pmid><doi>10.1007/s43032-020-00302-7</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-3214-6544</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1933-7191
ispartof Reproductive sciences (Thousand Oaks, Calif.), 2021-02, Vol.28 (2), p.510-523
issn 1933-7191
1933-7205
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7808996
source SpringerLink_现刊; Alma/SFX Local Collection
subjects Developmental Programming: Original
Developmental Programming: Original Article
Embryology
Medicine
Medicine & Public Health
Obstetrics/Perinatology/Midwifery
Reproductive Medicine
title The Effect of Exercise During Pregnancy on Maternal and Offspring Vascular Outcomes: a Pilot Study
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T11%3A09%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Effect%20of%20Exercise%20During%20Pregnancy%20on%20Maternal%20and%20Offspring%20Vascular%20Outcomes:%20a%20Pilot%20Study&rft.jtitle=Reproductive%20sciences%20(Thousand%20Oaks,%20Calif.)&rft.au=Brislane,%20%C3%81ine&rft.date=2021-02-01&rft.volume=28&rft.issue=2&rft.spage=510&rft.epage=523&rft.pages=510-523&rft.issn=1933-7191&rft.eissn=1933-7205&rft_id=info:doi/10.1007/s43032-020-00302-7&rft_dat=%3Cproquest_pubme%3E2466035469%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2466035469&rft_id=info:pmid/33258064&rfr_iscdi=true