Deficiency of Intestinal α1‐2‐Fucosylation Exacerbates Ethanol‐Induced Liver Disease in Mice

Background Fucosyltransferase 2 (Fut2)‐mediated intestinal α1‐2‐fucosylation is important in maintaining a symbiotic host–microbiota relationship and can protect against several pathogens. Intestinal dysbiosis is an important factor for the progression of experimental ethanol (EtOH)‐induced liver di...

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Veröffentlicht in:	Alcoholism, clinical and experimental research clinical and experimental research, 2020-09, Vol.44 (9), p.1842-1851
Hauptverfasser:	Zhou, Rongrong, Llorente, Cristina, Cao, Jinling, Gao, Bei, Duan, Yi, Jiang, Lu, Wang, Yanhan, Kumar, Vipin, Stärkel, Peter, Bode, Lars, Fan, Xuegong, Schnabl, Bernd
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol use Alcoholic Liver Disease Alcoholism Alcoholism - genetics Alcoholism - metabolism Alcoholism - microbiology Animals Breast milk Central Nervous System Depressants - toxicity Colonization Cytolysin Dietary supplements Disease Models, Animal Dysbacteriosis Dysbiosis - genetics Dysbiosis - metabolism Dysbiosis - microbiology Ethanol Ethanol - toxicity Fatty liver Fucosyltransferase 2 Fucosyltransferases - genetics Fucosyltransferases - metabolism Galactoside 2-a-L-fucosyltransferase Galactoside 2-alpha-L-fucosyltransferase Gastrointestinal Microbiome - drug effects Glycocalyx - drug effects Glycocalyx - metabolism Immunohistochemistry Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Intestine Liver - drug effects Liver - metabolism Liver - pathology Liver diseases Liver Diseases, Alcoholic - genetics Liver Diseases, Alcoholic - metabolism Liver Diseases, Alcoholic - microbiology Mice Microbiome Microbiota Oligosaccharides Steatosis
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