Cell cycle inertia underlies a bifurcation in cell fates after DNA damage

The G -S checkpoint is thought to prevent cells with damaged DNA from entering S phase and replicating their DNA and efficiently arrests cells at the G -S transition. Here, using time-lapse imaging and single-cell tracking, we instead find that DNA damage leads to highly variable and divergent fate...

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Veröffentlicht in:	Science advances 2021-01, Vol.7 (3)
Hauptverfasser:	Nathans, Jenny F, Cornwell, James A, Afifi, Marwa M, Paul, Debasish, Cappell, Steven D
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Biology SciAdv r-articles Systems Biology
Online-Zugang:	Volltext
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