Oxidized Low-Density Lipoprotein Drives Dysfunction of the Liver Lymphatic System

As the incidence of nonalcoholic steatohepatitis (NASH) continues to rise, understanding how normal liver functions are affected during disease is required before developing novel therapeutics which could reduce morbidity and mortality. However, very little is understood about how the transport of p...

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Veröffentlicht in:	Cellular and molecular gastroenterology and hepatology 2021-01, Vol.11 (2), p.573-595
Hauptverfasser:	Burchill, Matthew A., Finlon, Jeffrey M., Goldberg, Alyssa R., Gillen, Austin E., Dahms, Petra A., McMahan, Rachel H., Tye, Anne, Winter, Andrew B., Reisz, Julie A., Bohrnsen, Eric, Schafer, Johnathon B., D’Alessandro, Angelo, Orlicky, David J., Kriss, Michael S., Rosen, Hugo R., McCullough, Rebecca L., Jirón Tamburini, Beth A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Diet, High-Fat - adverse effects Disease Models, Animal Homeodomain Proteins - metabolism Humans Inflammation Intercellular Junctions - pathology Lipoproteins, LDL - metabolism Liver - immunology Liver - pathology Lymphangiogenesis Lymphatic Vessels - cytology Lymphatic Vessels - immunology Lymphatic Vessels - pathology Male Mice Non-alcoholic Fatty Liver Disease - immunology Non-alcoholic Fatty Liver Disease - metabolism Non-alcoholic Fatty Liver Disease - pathology Original Research Oxidized LDL Permeability Proteostasis - genetics Proteostasis - immunology RNA-Seq Single-Cell Analysis Tumor Suppressor Proteins - metabolism VEGFC
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