Influence of aging on deterioration of patients with COVID-19
Aging is an important factor affecting the deterioration of patients with coronavirus disease 2019 (COVID-19). The aging and degeneration of various tissues and organs in the elderly lead to impaired organ function. Underlying conditions such as chronic lung disease, cardiovascular disease, and diab...
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| Veröffentlicht in: | Aging (Albany, NY.) NY.), 2020-11, Vol.12 (24), p.26248-26262 |
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| container_title | Aging (Albany, NY.) |
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| creator | Pang, Limin Liu, Yi Shen, Maoze Ye, Jujian Chen, Ruirong Lan, Zhien Wu, Zhijian Guo, Yang Zhang, Peidong |
| description | Aging is an important factor affecting the deterioration of patients with coronavirus disease 2019 (COVID-19). The aging and degeneration of various tissues and organs in the elderly lead to impaired organ function. Underlying conditions such as chronic lung disease, cardiovascular disease, and diabetes in aged patients are associated with higher mortality. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily interacts with the cell surface receptor angiotensin-converting enzyme (ACE) 2 and other accessory proteins such as 78 kDa glucose-regulated protein 78 (GRP78) and CD147. Thus, altered receptor signals in aging and chronic disease play a role in SARS-CoV-2 infection, and are associated with a higher risk of deterioration in different organs. In this review, after a brief introduction to the link between aging and receptors for SARS-CoV-2, we focus on the risk of deterioration in different organs of COVID-19 patients considering aging as the main factor. We further discuss the structural and/or physiological changes in the immune system and organs (lung, heart, kidney, vessels, nerve system), as well as those associated with diabetes, in aging patients, and speculate on the most likely mechanisms underlying the deterioration of COVID-19 patients. |
| doi_str_mv | 10.18632/aging.202136 |
| format | Article |
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The aging and degeneration of various tissues and organs in the elderly lead to impaired organ function. Underlying conditions such as chronic lung disease, cardiovascular disease, and diabetes in aged patients are associated with higher mortality. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily interacts with the cell surface receptor angiotensin-converting enzyme (ACE) 2 and other accessory proteins such as 78 kDa glucose-regulated protein 78 (GRP78) and CD147. Thus, altered receptor signals in aging and chronic disease play a role in SARS-CoV-2 infection, and are associated with a higher risk of deterioration in different organs. In this review, after a brief introduction to the link between aging and receptors for SARS-CoV-2, we focus on the risk of deterioration in different organs of COVID-19 patients considering aging as the main factor. We further discuss the structural and/or physiological changes in the immune system and organs (lung, heart, kidney, vessels, nerve system), as well as those associated with diabetes, in aging patients, and speculate on the most likely mechanisms underlying the deterioration of COVID-19 patients.</description><identifier>ISSN: 1945-4589</identifier><identifier>EISSN: 1945-4589</identifier><identifier>DOI: 10.18632/aging.202136</identifier><identifier>PMID: 33232272</identifier><language>eng</language><publisher>United States: Impact Journals</publisher><subject>Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Aging ; Angiotensin-Converting Enzyme 2 - metabolism ; Biomarkers ; Child ; Child, Preschool ; Comorbidity ; COVID-19 - epidemiology ; COVID-19 - metabolism ; COVID-19 - virology ; Disease Susceptibility ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Mortality ; Patient Outcome Assessment ; Population Surveillance ; Receptors, Virus - metabolism ; Review ; SARS-CoV-2 ; Young Adult</subject><ispartof>Aging (Albany, NY.), 2020-11, Vol.12 (24), p.26248-26262</ispartof><rights>Copyright: © 2020 Pang et al.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-96f045d40a91bae9f68fce5e9914e8d1fd914bc27ee00ec7069c2ddc3872c2dc3</citedby><cites>FETCH-LOGICAL-c387t-96f045d40a91bae9f68fce5e9914e8d1fd914bc27ee00ec7069c2ddc3872c2dc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803552/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803552/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33232272$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pang, Limin</creatorcontrib><creatorcontrib>Liu, Yi</creatorcontrib><creatorcontrib>Shen, Maoze</creatorcontrib><creatorcontrib>Ye, Jujian</creatorcontrib><creatorcontrib>Chen, Ruirong</creatorcontrib><creatorcontrib>Lan, Zhien</creatorcontrib><creatorcontrib>Wu, Zhijian</creatorcontrib><creatorcontrib>Guo, Yang</creatorcontrib><creatorcontrib>Zhang, Peidong</creatorcontrib><title>Influence of aging on deterioration of patients with COVID-19</title><title>Aging (Albany, NY.)</title><addtitle>Aging (Albany NY)</addtitle><description>Aging is an important factor affecting the deterioration of patients with coronavirus disease 2019 (COVID-19). The aging and degeneration of various tissues and organs in the elderly lead to impaired organ function. Underlying conditions such as chronic lung disease, cardiovascular disease, and diabetes in aged patients are associated with higher mortality. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily interacts with the cell surface receptor angiotensin-converting enzyme (ACE) 2 and other accessory proteins such as 78 kDa glucose-regulated protein 78 (GRP78) and CD147. Thus, altered receptor signals in aging and chronic disease play a role in SARS-CoV-2 infection, and are associated with a higher risk of deterioration in different organs. In this review, after a brief introduction to the link between aging and receptors for SARS-CoV-2, we focus on the risk of deterioration in different organs of COVID-19 patients considering aging as the main factor. We further discuss the structural and/or physiological changes in the immune system and organs (lung, heart, kidney, vessels, nerve system), as well as those associated with diabetes, in aging patients, and speculate on the most likely mechanisms underlying the deterioration of COVID-19 patients.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Angiotensin-Converting Enzyme 2 - metabolism</subject><subject>Biomarkers</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Comorbidity</subject><subject>COVID-19 - epidemiology</subject><subject>COVID-19 - metabolism</subject><subject>COVID-19 - virology</subject><subject>Disease Susceptibility</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Patient Outcome Assessment</subject><subject>Population Surveillance</subject><subject>Receptors, Virus - metabolism</subject><subject>Review</subject><subject>SARS-CoV-2</subject><subject>Young Adult</subject><issn>1945-4589</issn><issn>1945-4589</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUE1PAjEUbIxGED16NXv0stjP3e1BE4NfJCRc1GtTuq9Qs2yxXTT-eysowdObl5k3bzIInRM8JFXB6JWeu3Y-pJgSVhygPpFc5FxU8nAP99BJjG8YF0Lw4hj1GKOM0pL20fW4tc0aWgOZt9nGK_NtVkMHwfmgO5e2xKwSgraL2afrFtlo-jq-y4k8RUdWNxHOfucAvTzcP4-e8sn0cTy6neSGVWWXy8JiLmqOtSQzDdIWlTUgQErCoaqJrROYGVoCYAymxIU0tK5_jmkChg3QzdZ3tZ4toTYpSdCNWgW31OFLee3Uf6Z1CzX3H6qsMBOCJoPLX4Pg39cQO7V00UDT6Bb8OirKC06qClORpPlWaoKPMYDdvSFYbSpXm5rUtvKkv9jPtlP_dcy-AV_Nfcg</recordid><startdate>20201124</startdate><enddate>20201124</enddate><creator>Pang, Limin</creator><creator>Liu, Yi</creator><creator>Shen, Maoze</creator><creator>Ye, Jujian</creator><creator>Chen, Ruirong</creator><creator>Lan, Zhien</creator><creator>Wu, Zhijian</creator><creator>Guo, Yang</creator><creator>Zhang, Peidong</creator><general>Impact Journals</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20201124</creationdate><title>Influence of aging on deterioration of patients with COVID-19</title><author>Pang, Limin ; Liu, Yi ; Shen, Maoze ; Ye, Jujian ; Chen, Ruirong ; Lan, Zhien ; Wu, Zhijian ; Guo, Yang ; Zhang, Peidong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-96f045d40a91bae9f68fce5e9914e8d1fd914bc27ee00ec7069c2ddc3872c2dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Angiotensin-Converting Enzyme 2 - metabolism</topic><topic>Biomarkers</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Comorbidity</topic><topic>COVID-19 - epidemiology</topic><topic>COVID-19 - metabolism</topic><topic>COVID-19 - virology</topic><topic>Disease Susceptibility</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Patient Outcome Assessment</topic><topic>Population Surveillance</topic><topic>Receptors, Virus - metabolism</topic><topic>Review</topic><topic>SARS-CoV-2</topic><topic>Young Adult</topic><toplevel>online_resources</toplevel><creatorcontrib>Pang, Limin</creatorcontrib><creatorcontrib>Liu, Yi</creatorcontrib><creatorcontrib>Shen, Maoze</creatorcontrib><creatorcontrib>Ye, Jujian</creatorcontrib><creatorcontrib>Chen, Ruirong</creatorcontrib><creatorcontrib>Lan, Zhien</creatorcontrib><creatorcontrib>Wu, Zhijian</creatorcontrib><creatorcontrib>Guo, Yang</creatorcontrib><creatorcontrib>Zhang, Peidong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Aging (Albany, NY.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pang, Limin</au><au>Liu, Yi</au><au>Shen, Maoze</au><au>Ye, Jujian</au><au>Chen, Ruirong</au><au>Lan, Zhien</au><au>Wu, Zhijian</au><au>Guo, Yang</au><au>Zhang, Peidong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of aging on deterioration of patients with COVID-19</atitle><jtitle>Aging (Albany, NY.)</jtitle><addtitle>Aging (Albany NY)</addtitle><date>2020-11-24</date><risdate>2020</risdate><volume>12</volume><issue>24</issue><spage>26248</spage><epage>26262</epage><pages>26248-26262</pages><issn>1945-4589</issn><eissn>1945-4589</eissn><abstract>Aging is an important factor affecting the deterioration of patients with coronavirus disease 2019 (COVID-19). The aging and degeneration of various tissues and organs in the elderly lead to impaired organ function. Underlying conditions such as chronic lung disease, cardiovascular disease, and diabetes in aged patients are associated with higher mortality. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily interacts with the cell surface receptor angiotensin-converting enzyme (ACE) 2 and other accessory proteins such as 78 kDa glucose-regulated protein 78 (GRP78) and CD147. Thus, altered receptor signals in aging and chronic disease play a role in SARS-CoV-2 infection, and are associated with a higher risk of deterioration in different organs. In this review, after a brief introduction to the link between aging and receptors for SARS-CoV-2, we focus on the risk of deterioration in different organs of COVID-19 patients considering aging as the main factor. 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| subjects | Adolescent Adult Age Factors Aged Aged, 80 and over Aging Angiotensin-Converting Enzyme 2 - metabolism Biomarkers Child Child, Preschool Comorbidity COVID-19 - epidemiology COVID-19 - metabolism COVID-19 - virology Disease Susceptibility Female Humans Infant Infant, Newborn Male Middle Aged Mortality Patient Outcome Assessment Population Surveillance Receptors, Virus - metabolism Review SARS-CoV-2 Young Adult |
| title | Influence of aging on deterioration of patients with COVID-19 |
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