Vitamin D and Immunoglobulin E Status in Allergic Rhinitis Patients Compared to Healthy People
Allergic rhinitis (AR) is a type of inflammatory condition that includes a group of symptoms, mainly affecting the nasal mucosa. Nasal obstruction, sneezing, stuffy or runny nose, in addition to swollen, itchy, red and watery eyes are the most common symptoms of the disease. These symptoms are trigg...
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| Veröffentlicht in: | Journal of medicine and life 2020-10, Vol.13 (4), p.463-468 |
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| description | Allergic rhinitis (AR) is a type of inflammatory condition that includes a group of symptoms, mainly affecting the nasal mucosa. Nasal obstruction, sneezing, stuffy or runny nose, in addition to swollen, itchy, red and watery eyes are the most common symptoms of the disease. These symptoms are triggered as a result of increased inflammatory mediators such as histamine and leukotrienes. Studies have recently shown the role of vitamin D (vit.D) in many allergic and immune conditions, where receptors for the active form of vit.D (1,25-dihydroxyvitamin D3) have been discovered on the surface of almost all types of inflammatory cells. Therefore, the present study was conducted to explore the level of vit. D in AR patients and its correlation with the severity of the disease. Two groups participated in the study; the first group included 49 patients who were diagnosed in a private otolaryngology clinic by the first author as having allergic rhinitis (AR group). The second one served as a control group and included 50 apparently healthy volunteers with no history of AR. The mean level of IgE and vit. D was found to be 326.3 and 10.2 ng/ml in the AR group, respectively, and 30.8 and 23.3 ng/ml in the control group, respectively. Ninety-three percent of AR patients have shown a deficiency in vit. D level, where 56% of this group showed severe deficiency. On the other hand, 34% of the control group has shown an insufficient level of vit. D. Additionally, 64% of AR patients have shown serum levels of IgE at values ranging between 100-299 ng/ml. Higher serum levels of IgE at values ranging between 300-599 ng/ml and 600-1000 ng/ml were observed in 25% and 11% of AR patients, respectively. The prevalence of low levels of vit. D in the AR group was significantly higher than that in the control group (P < 0.001). Vit. D deficiency is significantly related to severe AR symptoms and measuring serum vit. D level is recommended in the management plan of this group of patients. |
| doi_str_mv | 10.25122/jml-2020-0015 |
| format | Article |
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Nasal obstruction, sneezing, stuffy or runny nose, in addition to swollen, itchy, red and watery eyes are the most common symptoms of the disease. These symptoms are triggered as a result of increased inflammatory mediators such as histamine and leukotrienes. Studies have recently shown the role of vitamin D (vit.D) in many allergic and immune conditions, where receptors for the active form of vit.D (1,25-dihydroxyvitamin D3) have been discovered on the surface of almost all types of inflammatory cells. Therefore, the present study was conducted to explore the level of vit. D in AR patients and its correlation with the severity of the disease. Two groups participated in the study; the first group included 49 patients who were diagnosed in a private otolaryngology clinic by the first author as having allergic rhinitis (AR group). The second one served as a control group and included 50 apparently healthy volunteers with no history of AR. The mean level of IgE and vit. D was found to be 326.3 and 10.2 ng/ml in the AR group, respectively, and 30.8 and 23.3 ng/ml in the control group, respectively. Ninety-three percent of AR patients have shown a deficiency in vit. D level, where 56% of this group showed severe deficiency. On the other hand, 34% of the control group has shown an insufficient level of vit. D. Additionally, 64% of AR patients have shown serum levels of IgE at values ranging between 100-299 ng/ml. Higher serum levels of IgE at values ranging between 300-599 ng/ml and 600-1000 ng/ml were observed in 25% and 11% of AR patients, respectively. The prevalence of low levels of vit. D in the AR group was significantly higher than that in the control group (P < 0.001). Vit. D deficiency is significantly related to severe AR symptoms and measuring serum vit. D level is recommended in the management plan of this group of patients.</description><identifier>ISSN: 1844-122X</identifier><identifier>EISSN: 1844-3117</identifier><identifier>DOI: 10.25122/jml-2020-0015</identifier><identifier>PMID: 33456593</identifier><language>eng</language><publisher>Romania: Carol Daila University Foundation</publisher><subject>Adult ; Age ; Aged ; Allergens ; Allergic rhinitis ; Allergies ; Asthma ; Calcitriol ; Case-Control Studies ; Disease ; Female ; Histamine ; Humans ; Immunoassay ; Immunoglobulin E ; Immunoglobulin E - blood ; Immunoglobulin E - immunology ; Immunoglobulins ; Inflammation ; Leukotrienes ; Male ; Middle Aged ; Mucosa ; Nose ; Original ; Otolaryngology ; Patients ; Population ; Rhinitis, Allergic - blood ; Rhinitis, Allergic - immunology ; Serum levels ; Severity of Illness Index ; Sleep ; Vitamin D ; Vitamin D - blood ; Vitamin D3 ; Vitamin deficiency</subject><ispartof>Journal of medicine and life, 2020-10, Vol.13 (4), p.463-468</ispartof><rights>Carol Davila University Press.</rights><rights>Copyright Carol Daila University Foundation Oct-Dec 2020</rights><rights>Carol Davila University Press 2020</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3335-2942ab62cb073537ffb15d55f22b8f03dcb3dafcc7e8a6aad3c3907992f99c93</citedby><cites>FETCH-LOGICAL-c3335-2942ab62cb073537ffb15d55f22b8f03dcb3dafcc7e8a6aad3c3907992f99c93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803312/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803312/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33456593$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alnori, Haitham</creatorcontrib><creatorcontrib>Alassaf, Fawaz Abdulghani</creatorcontrib><creatorcontrib>Alfahad, Mohanad</creatorcontrib><creatorcontrib>Qazzaz, Mohannad Emad</creatorcontrib><creatorcontrib>Jasim, Mahmood</creatorcontrib><creatorcontrib>Abed, Mohammed Najim</creatorcontrib><creatorcontrib>Department of Pharmacognosy and Medicinal Plants, College of Pharmacy, University of Mosul, Mosul, Iraq</creatorcontrib><creatorcontrib>Haitham Alnori,Department of Surgery, College of Medicine,University of Mosul,Mosul Ninavah 00964 Iraq.Phone: 009647701637724 E-mail: haithamabdnori@uomosul.edu.iq</creatorcontrib><creatorcontrib>Department of Surgery, College of Medicine, University of Mosul, Mosul, Iraq</creatorcontrib><creatorcontrib>Department of Pharmacology, College of Pharmacy, University of Mosul, Mosul, Iraq</creatorcontrib><creatorcontrib>Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, Iraq</creatorcontrib><creatorcontrib>Department of Pharmaceutics, College of Pharmacy, University of Mosul, Mosul, Iraq</creatorcontrib><title>Vitamin D and Immunoglobulin E Status in Allergic Rhinitis Patients Compared to Healthy People</title><title>Journal of medicine and life</title><addtitle>J Med Life</addtitle><description>Allergic rhinitis (AR) is a type of inflammatory condition that includes a group of symptoms, mainly affecting the nasal mucosa. Nasal obstruction, sneezing, stuffy or runny nose, in addition to swollen, itchy, red and watery eyes are the most common symptoms of the disease. These symptoms are triggered as a result of increased inflammatory mediators such as histamine and leukotrienes. Studies have recently shown the role of vitamin D (vit.D) in many allergic and immune conditions, where receptors for the active form of vit.D (1,25-dihydroxyvitamin D3) have been discovered on the surface of almost all types of inflammatory cells. Therefore, the present study was conducted to explore the level of vit. D in AR patients and its correlation with the severity of the disease. Two groups participated in the study; the first group included 49 patients who were diagnosed in a private otolaryngology clinic by the first author as having allergic rhinitis (AR group). The second one served as a control group and included 50 apparently healthy volunteers with no history of AR. The mean level of IgE and vit. D was found to be 326.3 and 10.2 ng/ml in the AR group, respectively, and 30.8 and 23.3 ng/ml in the control group, respectively. Ninety-three percent of AR patients have shown a deficiency in vit. D level, where 56% of this group showed severe deficiency. On the other hand, 34% of the control group has shown an insufficient level of vit. D. Additionally, 64% of AR patients have shown serum levels of IgE at values ranging between 100-299 ng/ml. Higher serum levels of IgE at values ranging between 300-599 ng/ml and 600-1000 ng/ml were observed in 25% and 11% of AR patients, respectively. The prevalence of low levels of vit. D in the AR group was significantly higher than that in the control group (P < 0.001). Vit. D deficiency is significantly related to severe AR symptoms and measuring serum vit. D level is recommended in the management plan of this group of patients.</description><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Allergens</subject><subject>Allergic rhinitis</subject><subject>Allergies</subject><subject>Asthma</subject><subject>Calcitriol</subject><subject>Case-Control Studies</subject><subject>Disease</subject><subject>Female</subject><subject>Histamine</subject><subject>Humans</subject><subject>Immunoassay</subject><subject>Immunoglobulin E</subject><subject>Immunoglobulin E - blood</subject><subject>Immunoglobulin E - immunology</subject><subject>Immunoglobulins</subject><subject>Inflammation</subject><subject>Leukotrienes</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mucosa</subject><subject>Nose</subject><subject>Original</subject><subject>Otolaryngology</subject><subject>Patients</subject><subject>Population</subject><subject>Rhinitis, Allergic - blood</subject><subject>Rhinitis, Allergic - immunology</subject><subject>Serum levels</subject><subject>Severity of Illness Index</subject><subject>Sleep</subject><subject>Vitamin D</subject><subject>Vitamin D - blood</subject><subject>Vitamin D3</subject><subject>Vitamin deficiency</subject><issn>1844-122X</issn><issn>1844-3117</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkcFLHDEYxUNpUbFePZaAl17GJvkmk8mlIFurgqC0UjwZMpnMbpbMZE0yBf_7ZnUrtbnk8eWXx_t4CB1Tcso4ZezLevQVI4xUhFD-Dh3Qtq4roFS83-kC3e-jo5TWpJyaN00De2gfoEgu4QA9_HJZj27C37Ceenw1jvMUlj50sy_Dc_wz6zwnXPSZ9zYuncE_Vm5y2SV8q7OzU054EcaNjrbHOeBLq31ePeFbGzbefkQfBu2TPdrdh-ju-_nd4rK6vrm4WpxdVwYAeMVkzXTXMNMRARzEMHSU95wPjHXtQKA3HfR6MEbYVjda92BAEiElG6Q0Eg7R1xfbzdyNtjclVdRebaIbdXxSQTv19mVyK7UMv5VoCQBlxeDzziCGx9mmrEaXjPVeTzbMSbFatEJIkKKgJ_-h6zDHqWxXqLZ4UUm2iU5fKBNDStEOr2EoUc_lqVKe2pantuWVD5_-XeEV_1sV_AEPjJXd</recordid><startdate>202010</startdate><enddate>202010</enddate><creator>Alnori, Haitham</creator><creator>Alassaf, Fawaz Abdulghani</creator><creator>Alfahad, Mohanad</creator><creator>Qazzaz, Mohannad Emad</creator><creator>Jasim, Mahmood</creator><creator>Abed, Mohammed Najim</creator><general>Carol Daila University Foundation</general><general>Carol Davila University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BYOGL</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>202010</creationdate><title>Vitamin D and Immunoglobulin E Status in Allergic Rhinitis Patients Compared to Healthy People</title><author>Alnori, Haitham ; Alassaf, Fawaz Abdulghani ; Alfahad, Mohanad ; Qazzaz, Mohannad Emad ; Jasim, Mahmood ; Abed, Mohammed Najim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3335-2942ab62cb073537ffb15d55f22b8f03dcb3dafcc7e8a6aad3c3907992f99c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Allergens</topic><topic>Allergic rhinitis</topic><topic>Allergies</topic><topic>Asthma</topic><topic>Calcitriol</topic><topic>Case-Control Studies</topic><topic>Disease</topic><topic>Female</topic><topic>Histamine</topic><topic>Humans</topic><topic>Immunoassay</topic><topic>Immunoglobulin E</topic><topic>Immunoglobulin E - blood</topic><topic>Immunoglobulin E - immunology</topic><topic>Immunoglobulins</topic><topic>Inflammation</topic><topic>Leukotrienes</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mucosa</topic><topic>Nose</topic><topic>Original</topic><topic>Otolaryngology</topic><topic>Patients</topic><topic>Population</topic><topic>Rhinitis, Allergic - blood</topic><topic>Rhinitis, Allergic - immunology</topic><topic>Serum levels</topic><topic>Severity of Illness Index</topic><topic>Sleep</topic><topic>Vitamin D</topic><topic>Vitamin D - blood</topic><topic>Vitamin D3</topic><topic>Vitamin deficiency</topic><toplevel>online_resources</toplevel><creatorcontrib>Alnori, Haitham</creatorcontrib><creatorcontrib>Alassaf, Fawaz Abdulghani</creatorcontrib><creatorcontrib>Alfahad, Mohanad</creatorcontrib><creatorcontrib>Qazzaz, Mohannad Emad</creatorcontrib><creatorcontrib>Jasim, Mahmood</creatorcontrib><creatorcontrib>Abed, Mohammed Najim</creatorcontrib><creatorcontrib>Department of Pharmacognosy and Medicinal Plants, College of Pharmacy, University of Mosul, Mosul, Iraq</creatorcontrib><creatorcontrib>Haitham Alnori,Department of Surgery, College of Medicine,University of Mosul,Mosul Ninavah 00964 Iraq.Phone: 009647701637724 E-mail: haithamabdnori@uomosul.edu.iq</creatorcontrib><creatorcontrib>Department of Surgery, College of Medicine, University of Mosul, Mosul, Iraq</creatorcontrib><creatorcontrib>Department of Pharmacology, College of Pharmacy, University of Mosul, Mosul, Iraq</creatorcontrib><creatorcontrib>Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, Iraq</creatorcontrib><creatorcontrib>Department of Pharmaceutics, College of Pharmacy, University of Mosul, Mosul, Iraq</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>East Europe, Central Europe Database</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of medicine and life</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alnori, Haitham</au><au>Alassaf, Fawaz Abdulghani</au><au>Alfahad, Mohanad</au><au>Qazzaz, Mohannad Emad</au><au>Jasim, Mahmood</au><au>Abed, Mohammed Najim</au><aucorp>Department of Pharmacognosy and Medicinal Plants, College of Pharmacy, University of Mosul, Mosul, Iraq</aucorp><aucorp>Haitham Alnori,Department of Surgery, College of Medicine,University of Mosul,Mosul Ninavah 00964 Iraq.Phone: 009647701637724 E-mail: haithamabdnori@uomosul.edu.iq</aucorp><aucorp>Department of Surgery, College of Medicine, University of Mosul, Mosul, Iraq</aucorp><aucorp>Department of Pharmacology, College of Pharmacy, University of Mosul, Mosul, Iraq</aucorp><aucorp>Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, Iraq</aucorp><aucorp>Department of Pharmaceutics, College of Pharmacy, University of Mosul, Mosul, Iraq</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin D and Immunoglobulin E Status in Allergic Rhinitis Patients Compared to Healthy People</atitle><jtitle>Journal of medicine and life</jtitle><addtitle>J Med Life</addtitle><date>2020-10</date><risdate>2020</risdate><volume>13</volume><issue>4</issue><spage>463</spage><epage>468</epage><pages>463-468</pages><issn>1844-122X</issn><eissn>1844-3117</eissn><abstract>Allergic rhinitis (AR) is a type of inflammatory condition that includes a group of symptoms, mainly affecting the nasal mucosa. Nasal obstruction, sneezing, stuffy or runny nose, in addition to swollen, itchy, red and watery eyes are the most common symptoms of the disease. These symptoms are triggered as a result of increased inflammatory mediators such as histamine and leukotrienes. Studies have recently shown the role of vitamin D (vit.D) in many allergic and immune conditions, where receptors for the active form of vit.D (1,25-dihydroxyvitamin D3) have been discovered on the surface of almost all types of inflammatory cells. Therefore, the present study was conducted to explore the level of vit. D in AR patients and its correlation with the severity of the disease. Two groups participated in the study; the first group included 49 patients who were diagnosed in a private otolaryngology clinic by the first author as having allergic rhinitis (AR group). The second one served as a control group and included 50 apparently healthy volunteers with no history of AR. The mean level of IgE and vit. D was found to be 326.3 and 10.2 ng/ml in the AR group, respectively, and 30.8 and 23.3 ng/ml in the control group, respectively. Ninety-three percent of AR patients have shown a deficiency in vit. D level, where 56% of this group showed severe deficiency. On the other hand, 34% of the control group has shown an insufficient level of vit. D. Additionally, 64% of AR patients have shown serum levels of IgE at values ranging between 100-299 ng/ml. Higher serum levels of IgE at values ranging between 300-599 ng/ml and 600-1000 ng/ml were observed in 25% and 11% of AR patients, respectively. The prevalence of low levels of vit. D in the AR group was significantly higher than that in the control group (P < 0.001). Vit. D deficiency is significantly related to severe AR symptoms and measuring serum vit. D level is recommended in the management plan of this group of patients.</abstract><cop>Romania</cop><pub>Carol Daila University Foundation</pub><pmid>33456593</pmid><doi>10.25122/jml-2020-0015</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Aged Allergens Allergic rhinitis Allergies Asthma Calcitriol Case-Control Studies Disease Female Histamine Humans Immunoassay Immunoglobulin E Immunoglobulin E - blood Immunoglobulin E - immunology Immunoglobulins Inflammation Leukotrienes Male Middle Aged Mucosa Nose Original Otolaryngology Patients Population Rhinitis, Allergic - blood Rhinitis, Allergic - immunology Serum levels Severity of Illness Index Sleep Vitamin D Vitamin D - blood Vitamin D3 Vitamin deficiency |
| title | Vitamin D and Immunoglobulin E Status in Allergic Rhinitis Patients Compared to Healthy People |
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