Effect of herbal formulation intake on health indices in albino Wistar rat model
Dyslipidemia management activity of ginger‐, garlic‐, and lemon‐based herbal mixture was tested as paste and herbal extract in hypercholesterolemic adult male albino rats. Atherogenic diet‐induced hypercholesterolemia in rats was treated by supplementing the diet with 2.5% herbal paste (4.2 g/kg b.w...
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| Veröffentlicht in: | Food Science & Nutrition 2021-01, Vol.9 (1), p.441-448 |
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| creator | Naseem, Adila Akhtar, Saeed Manzoor, Muhammad Faisal Sameen, Aysha Layla, Anam Afzal, Khurram Karrar, Emad Rahaman, Abdul Ismail, Tariq Ahmad, Nazir Siddeeg, Azhari |
| description | Dyslipidemia management activity of ginger‐, garlic‐, and lemon‐based herbal mixture was tested as paste and herbal extract in hypercholesterolemic adult male albino rats. Atherogenic diet‐induced hypercholesterolemia in rats was treated by supplementing the diet with 2.5% herbal paste (4.2 g/kg b.w.) or 2.5 ml oral gavage (20 ml/kg b.w.) of liquid herbal extract daily for 42 days. Hematological and serological outcomes of herbal formulation feeding were compared with the cholesterol‐fed positive control and normal control. The results suggest the significant (p |
| doi_str_mv | 10.1002/fsn3.2009 |
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Herbal medicines are primitive and conventional therapeutics for around 80% of the world's population due to their wide acceptability, availability, and affordability while their safety claims are in the process of validation in line with the consumer safety standards of the recent era. Findings of this subchronic exposure study on evaluating the synergistic effect of garlic‐, ginger‐, onion‐, apple cider vinegar‐, and honey‐based conventional herbal formulations against dyslipidemia validated existing therapeutic claims of the recipe.</description><identifier>ISSN: 2048-7177</identifier><identifier>EISSN: 2048-7177</identifier><identifier>DOI: 10.1002/fsn3.2009</identifier><identifier>PMID: 33473305</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>Albinism ; Albumin ; Animal models ; Anticholesteremic agents ; Atherogenic diet ; Atherosclerosis ; Bilirubin ; Bioassays ; Cholesterol ; Comparative analysis ; Diabetes ; Diet ; Dyslipidemia ; Enzymes ; Ethylenediaminetetraacetic acid ; Feeds ; Formulations ; Garlic ; Ginger ; Heart ; Hematology ; Herbs ; Honey ; Hypercholesterolemia ; Inflammatory diseases ; Laboratory animals ; Lipids ; Lipoproteins ; Low density lipoprotein ; Low density lipoproteins ; Lymphocytes ; Medicine, Botanic ; Medicine, Herbal ; Metabolic disorders ; Mortality ; Nutrition research ; Original Research ; Plant extracts ; Risk factors ; Serology ; Serum albumin ; toxicity ; Traditional medicine ; Triglycerides ; Variance analysis ; Vinegar</subject><ispartof>Food Science & Nutrition, 2021-01, Vol.9 (1), p.441-448</ispartof><rights>2020 The Authors. published by Wiley Periodicals LLC</rights><rights>2020 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC.</rights><rights>COPYRIGHT 2020 John Wiley & Sons, Inc.</rights><rights>2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5389-11a16e7ead38047284a520e3c180135e2501b80ec39f3176d82676bf1a28d2a63</citedby><cites>FETCH-LOGICAL-c5389-11a16e7ead38047284a520e3c180135e2501b80ec39f3176d82676bf1a28d2a63</cites><orcidid>0000-0002-3705-0277 ; 0000-0003-3151-0276 ; 0000-0003-1031-1251 ; 0000-0002-7680-8423 ; 0000-0002-3206-1962</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802562/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802562/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,11543,27903,27904,45553,45554,46030,46454,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33473305$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Naseem, Adila</creatorcontrib><creatorcontrib>Akhtar, Saeed</creatorcontrib><creatorcontrib>Manzoor, Muhammad Faisal</creatorcontrib><creatorcontrib>Sameen, Aysha</creatorcontrib><creatorcontrib>Layla, Anam</creatorcontrib><creatorcontrib>Afzal, Khurram</creatorcontrib><creatorcontrib>Karrar, Emad</creatorcontrib><creatorcontrib>Rahaman, Abdul</creatorcontrib><creatorcontrib>Ismail, Tariq</creatorcontrib><creatorcontrib>Ahmad, Nazir</creatorcontrib><creatorcontrib>Siddeeg, Azhari</creatorcontrib><title>Effect of herbal formulation intake on health indices in albino Wistar rat model</title><title>Food Science & Nutrition</title><addtitle>Food Sci Nutr</addtitle><description>Dyslipidemia management activity of ginger‐, garlic‐, and lemon‐based herbal mixture was tested as paste and herbal extract in hypercholesterolemic adult male albino rats. Atherogenic diet‐induced hypercholesterolemia in rats was treated by supplementing the diet with 2.5% herbal paste (4.2 g/kg b.w.) or 2.5 ml oral gavage (20 ml/kg b.w.) of liquid herbal extract daily for 42 days. Hematological and serological outcomes of herbal formulation feeding were compared with the cholesterol‐fed positive control and normal control. The results suggest the significant (p < .05) inhibitory properties of herbal paste and liquid extracts against dyslipidemia showing 31%–37%, 62%–68%, and 40%–56% lower levels of total cholesterol, triglycerides (TGs), and low‐density lipoprotein cholesterol (LDL‐C), respectively. Treating cholesterol‐fed animals with herbal paste and extract significantly (p < .05) increased total protein (5–5.5 g/dl) and serum albumin (3.7–4.2 g/dl) concentration as compared to the normal control. Contrary to significant hypocholesterolemic activity, higher serum total bilirubin levels, that is, 0.70 mg/dl, were observed in rats subchronically exposed to herbal paste and liquid extracts. Nonsignificant (p > .05) impact of herbal formula feeding was observed on hematological indices except lymphocyte counts, that is, 93% in rats fed on herbal paste. The results validate conventional hypocholesterolemic claims associated with ginger‐, garlic‐, and lemon‐based herbal formulations; however, deeper insight into their dose‐dependent response in hypercholesterolemia is necessitated to rule out the toxicological impact on the consumer.
Herbal medicines are primitive and conventional therapeutics for around 80% of the world's population due to their wide acceptability, availability, and affordability while their safety claims are in the process of validation in line with the consumer safety standards of the recent era. Findings of this subchronic exposure study on evaluating the synergistic effect of garlic‐, ginger‐, onion‐, apple cider vinegar‐, and honey‐based conventional herbal formulations against dyslipidemia validated existing therapeutic claims of the recipe.</description><subject>Albinism</subject><subject>Albumin</subject><subject>Animal models</subject><subject>Anticholesteremic agents</subject><subject>Atherogenic diet</subject><subject>Atherosclerosis</subject><subject>Bilirubin</subject><subject>Bioassays</subject><subject>Cholesterol</subject><subject>Comparative analysis</subject><subject>Diabetes</subject><subject>Diet</subject><subject>Dyslipidemia</subject><subject>Enzymes</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Feeds</subject><subject>Formulations</subject><subject>Garlic</subject><subject>Ginger</subject><subject>Heart</subject><subject>Hematology</subject><subject>Herbs</subject><subject>Honey</subject><subject>Hypercholesterolemia</subject><subject>Inflammatory diseases</subject><subject>Laboratory animals</subject><subject>Lipids</subject><subject>Lipoproteins</subject><subject>Low density lipoprotein</subject><subject>Low density lipoproteins</subject><subject>Lymphocytes</subject><subject>Medicine, Botanic</subject><subject>Medicine, Herbal</subject><subject>Metabolic disorders</subject><subject>Mortality</subject><subject>Nutrition research</subject><subject>Original Research</subject><subject>Plant extracts</subject><subject>Risk factors</subject><subject>Serology</subject><subject>Serum albumin</subject><subject>toxicity</subject><subject>Traditional medicine</subject><subject>Triglycerides</subject><subject>Variance analysis</subject><subject>Vinegar</subject><issn>2048-7177</issn><issn>2048-7177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kUFPFTEQxxsjEQIc_AKmiScP7zFtd9vuxYQQEBOiJGg8Nt3ulFfcbbHdh-Hb08dDggdtDzOZ_uY_0_wJectgyQD4kS9RLDlA94rscWj0QjGlXr_Id8lhKTdQT9cwyfkbsitEo4SAdo9cnnqPbqbJ0xXm3o7UpzytRzuHFGmIs_2JtGYrtOO8qoUhOCw1Ujv2ISb6I5TZZprtTKc04HhAdrwdCx4-xX3y_ez028n54uLrp88nxxcL1wrdLRizTKJCOwgNjeK6sS0HFI5pYKJF3gLrNaATnRdMyUFzqWTvmeV64FaKffJxq3u77iccHMY529Hc5jDZfG-SDebvlxhW5jrdGaWBt5JXgfdPAjn9WmOZzU1a51h3NgKarpOKsf9SvFFS8wYeqeWWurYjmhB9qiNdvQNOwaWIPtT6sQItWt1xXRs-bBtcTqVk9M-LMzAbW83GVrOxtbLvXv70mfxjYgWOtsDvOuX-30rm7OqLeJR8ALH0qdo</recordid><startdate>202101</startdate><enddate>202101</enddate><creator>Naseem, Adila</creator><creator>Akhtar, Saeed</creator><creator>Manzoor, Muhammad 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of herbal formulation intake on health indices in albino Wistar rat model</title><author>Naseem, Adila ; Akhtar, Saeed ; Manzoor, Muhammad Faisal ; Sameen, Aysha ; Layla, Anam ; Afzal, Khurram ; Karrar, Emad ; Rahaman, Abdul ; Ismail, Tariq ; Ahmad, Nazir ; Siddeeg, Azhari</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5389-11a16e7ead38047284a520e3c180135e2501b80ec39f3176d82676bf1a28d2a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Albinism</topic><topic>Albumin</topic><topic>Animal models</topic><topic>Anticholesteremic agents</topic><topic>Atherogenic diet</topic><topic>Atherosclerosis</topic><topic>Bilirubin</topic><topic>Bioassays</topic><topic>Cholesterol</topic><topic>Comparative analysis</topic><topic>Diabetes</topic><topic>Diet</topic><topic>Dyslipidemia</topic><topic>Enzymes</topic><topic>Ethylenediaminetetraacetic acid</topic><topic>Feeds</topic><topic>Formulations</topic><topic>Garlic</topic><topic>Ginger</topic><topic>Heart</topic><topic>Hematology</topic><topic>Herbs</topic><topic>Honey</topic><topic>Hypercholesterolemia</topic><topic>Inflammatory diseases</topic><topic>Laboratory animals</topic><topic>Lipids</topic><topic>Lipoproteins</topic><topic>Low density lipoprotein</topic><topic>Low density lipoproteins</topic><topic>Lymphocytes</topic><topic>Medicine, Botanic</topic><topic>Medicine, Herbal</topic><topic>Metabolic disorders</topic><topic>Mortality</topic><topic>Nutrition research</topic><topic>Original Research</topic><topic>Plant extracts</topic><topic>Risk factors</topic><topic>Serology</topic><topic>Serum albumin</topic><topic>toxicity</topic><topic>Traditional medicine</topic><topic>Triglycerides</topic><topic>Variance analysis</topic><topic>Vinegar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Naseem, 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Nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Naseem, Adila</au><au>Akhtar, Saeed</au><au>Manzoor, Muhammad Faisal</au><au>Sameen, Aysha</au><au>Layla, Anam</au><au>Afzal, Khurram</au><au>Karrar, Emad</au><au>Rahaman, Abdul</au><au>Ismail, Tariq</au><au>Ahmad, Nazir</au><au>Siddeeg, Azhari</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of herbal formulation intake on health indices in albino Wistar rat model</atitle><jtitle>Food Science & Nutrition</jtitle><addtitle>Food Sci Nutr</addtitle><date>2021-01</date><risdate>2021</risdate><volume>9</volume><issue>1</issue><spage>441</spage><epage>448</epage><pages>441-448</pages><issn>2048-7177</issn><eissn>2048-7177</eissn><abstract>Dyslipidemia management activity of ginger‐, garlic‐, and lemon‐based herbal mixture was tested as paste and herbal extract in hypercholesterolemic adult male albino rats. Atherogenic diet‐induced hypercholesterolemia in rats was treated by supplementing the diet with 2.5% herbal paste (4.2 g/kg b.w.) or 2.5 ml oral gavage (20 ml/kg b.w.) of liquid herbal extract daily for 42 days. Hematological and serological outcomes of herbal formulation feeding were compared with the cholesterol‐fed positive control and normal control. The results suggest the significant (p < .05) inhibitory properties of herbal paste and liquid extracts against dyslipidemia showing 31%–37%, 62%–68%, and 40%–56% lower levels of total cholesterol, triglycerides (TGs), and low‐density lipoprotein cholesterol (LDL‐C), respectively. Treating cholesterol‐fed animals with herbal paste and extract significantly (p < .05) increased total protein (5–5.5 g/dl) and serum albumin (3.7–4.2 g/dl) concentration as compared to the normal control. Contrary to significant hypocholesterolemic activity, higher serum total bilirubin levels, that is, 0.70 mg/dl, were observed in rats subchronically exposed to herbal paste and liquid extracts. Nonsignificant (p > .05) impact of herbal formula feeding was observed on hematological indices except lymphocyte counts, that is, 93% in rats fed on herbal paste. The results validate conventional hypocholesterolemic claims associated with ginger‐, garlic‐, and lemon‐based herbal formulations; however, deeper insight into their dose‐dependent response in hypercholesterolemia is necessitated to rule out the toxicological impact on the consumer.
Herbal medicines are primitive and conventional therapeutics for around 80% of the world's population due to their wide acceptability, availability, and affordability while their safety claims are in the process of validation in line with the consumer safety standards of the recent era. Findings of this subchronic exposure study on evaluating the synergistic effect of garlic‐, ginger‐, onion‐, apple cider vinegar‐, and honey‐based conventional herbal formulations against dyslipidemia validated existing therapeutic claims of the recipe.</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>33473305</pmid><doi>10.1002/fsn3.2009</doi><tpages>0</tpages><orcidid>https://orcid.org/0000-0002-3705-0277</orcidid><orcidid>https://orcid.org/0000-0003-3151-0276</orcidid><orcidid>https://orcid.org/0000-0003-1031-1251</orcidid><orcidid>https://orcid.org/0000-0002-7680-8423</orcidid><orcidid>https://orcid.org/0000-0002-3206-1962</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Food Science & Nutrition, 2021-01, Vol.9 (1), p.441-448 |
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| source | Wiley-Blackwell Open Access Titles; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Albinism Albumin Animal models Anticholesteremic agents Atherogenic diet Atherosclerosis Bilirubin Bioassays Cholesterol Comparative analysis Diabetes Diet Dyslipidemia Enzymes Ethylenediaminetetraacetic acid Feeds Formulations Garlic Ginger Heart Hematology Herbs Honey Hypercholesterolemia Inflammatory diseases Laboratory animals Lipids Lipoproteins Low density lipoprotein Low density lipoproteins Lymphocytes Medicine, Botanic Medicine, Herbal Metabolic disorders Mortality Nutrition research Original Research Plant extracts Risk factors Serology Serum albumin toxicity Traditional medicine Triglycerides Variance analysis Vinegar |
| title | Effect of herbal formulation intake on health indices in albino Wistar rat model |
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