An overview of neuroblastoma cell lineage phenotypes and in vitro models
This review was conducted to present the main neuroblastoma (NB) clinical characteristics and the most common genetic alterations present in these pediatric tumors, highlighting their impact in tumor cell aggressiveness behavior, including metastatic development and treatment resistance, and patient...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 2020-12, Vol.245 (18), p.1637-1647 |
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| creator | Campos Cogo, Sheron Gradowski Farias da Costa do Nascimento, Thatyanne de Almeida Brehm Pinhatti, Fernanda de França Junior, Nilton Santos Rodrigues, Bruna Cavalli, Luciane Regina Elifio-Esposito, Selene |
| description | This review was conducted to present the main neuroblastoma (NB) clinical characteristics and the most common genetic alterations present in these pediatric tumors, highlighting their impact in tumor cell aggressiveness behavior, including metastatic development and treatment resistance, and patients’ prognosis. The distinct three NB cell lineage phenotypes, S-type, N-type, and I-type, which are characterized by unique cell surface markers and gene expression patterns, are also reviewed. Finally, an overview of the most used NB cell lines currently available for in vitro studies and their unique cellular and molecular characteristics, which should be taken into account for the selection of the most appropriate model for NB pre-clinical studies, is presented. These valuable models can be complemented by the generation of NB reprogrammed tumor cells or organoids, derived directly from patients’ tumor specimens, in the direction toward personalized medicine. |
| doi_str_mv | 10.1177/1535370220949237 |
| format | Article |
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The distinct three NB cell lineage phenotypes, S-type, N-type, and I-type, which are characterized by unique cell surface markers and gene expression patterns, are also reviewed. Finally, an overview of the most used NB cell lines currently available for in vitro studies and their unique cellular and molecular characteristics, which should be taken into account for the selection of the most appropriate model for NB pre-clinical studies, is presented. These valuable models can be complemented by the generation of NB reprogrammed tumor cells or organoids, derived directly from patients’ tumor specimens, in the direction toward personalized medicine.</description><subject>Biomarkers, Tumor - metabolism</subject><subject>Cell Line, Tumor</subject><subject>Cell Lineage</subject><subject>Humans</subject><subject>Minireview</subject><subject>Models, Biological</subject><subject>Neuroblastoma - genetics</subject><subject>Neuroblastoma - pathology</subject><subject>Phenotype</subject><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UU1PwzAMjRCIjcGdE8qRSyFfbdoL0jQBQ5rEBc5RljpbpzYZSTu0f0-nbQiQONnye362nxG6puSOUinvacpTLgljpBAF4_IEDXelhGdFcXrMe3yALmJcEUJTybJzNOBM5lJkfIimY4f9BsKmgk_sLXbQBT-vdWx9o7GBusZ15UAvAK-X4Hy7XUPE2pW4cnhTtcHjxpdQx0t0ZnUd4eoQR-j96fFtMk1mr88vk_EsMZzINpEFsZBq4HSeiiy3qcypkJkW1AhrClGWOTOUEpvpOaGlzbmwrMeYNEZzUvARetjrrrt5A6UB1wZdq3WoGh22yutK_UZctVQLv1EyJ4znohe4PQgE_9FBbFVTxd2h2oHvomKCC5LKtNhRyZ5qgo8xgP0eQ4naPUD9fUDfcvNzve-Go-M9IdkTYu-pWvkuuN6u_wW_AL4sjls</recordid><startdate>20201201</startdate><enddate>20201201</enddate><creator>Campos Cogo, Sheron</creator><creator>Gradowski Farias da Costa do Nascimento, Thatyanne</creator><creator>de Almeida Brehm Pinhatti, Fernanda</creator><creator>de França Junior, Nilton</creator><creator>Santos Rodrigues, Bruna</creator><creator>Cavalli, Luciane Regina</creator><creator>Elifio-Esposito, Selene</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8676-134X</orcidid><orcidid>https://orcid.org/0000-0001-8137-5186</orcidid></search><sort><creationdate>20201201</creationdate><title>An overview of neuroblastoma cell lineage phenotypes and in vitro models</title><author>Campos Cogo, Sheron ; Gradowski Farias da Costa do Nascimento, Thatyanne ; de Almeida Brehm Pinhatti, Fernanda ; de França Junior, Nilton ; Santos Rodrigues, Bruna ; Cavalli, Luciane Regina ; Elifio-Esposito, Selene</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c307t-790fe5ae31b5468f5781476a41c4fc94dd82c110f6ab01df834f21c427cca3093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Biomarkers, Tumor - metabolism</topic><topic>Cell Line, Tumor</topic><topic>Cell Lineage</topic><topic>Humans</topic><topic>Minireview</topic><topic>Models, Biological</topic><topic>Neuroblastoma - genetics</topic><topic>Neuroblastoma - pathology</topic><topic>Phenotype</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Campos Cogo, Sheron</creatorcontrib><creatorcontrib>Gradowski Farias da Costa do Nascimento, Thatyanne</creatorcontrib><creatorcontrib>de Almeida Brehm Pinhatti, Fernanda</creatorcontrib><creatorcontrib>de França Junior, Nilton</creatorcontrib><creatorcontrib>Santos Rodrigues, Bruna</creatorcontrib><creatorcontrib>Cavalli, Luciane Regina</creatorcontrib><creatorcontrib>Elifio-Esposito, Selene</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Campos Cogo, Sheron</au><au>Gradowski Farias da Costa do Nascimento, Thatyanne</au><au>de Almeida Brehm Pinhatti, Fernanda</au><au>de França Junior, Nilton</au><au>Santos Rodrigues, Bruna</au><au>Cavalli, Luciane Regina</au><au>Elifio-Esposito, Selene</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An overview of neuroblastoma cell lineage phenotypes and in vitro models</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Exp Biol Med (Maywood)</addtitle><date>2020-12-01</date><risdate>2020</risdate><volume>245</volume><issue>18</issue><spage>1637</spage><epage>1647</epage><pages>1637-1647</pages><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>This review was conducted to present the main neuroblastoma (NB) clinical characteristics and the most common genetic alterations present in these pediatric tumors, highlighting their impact in tumor cell aggressiveness behavior, including metastatic development and treatment resistance, and patients’ prognosis. 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| source | MEDLINE; SAGE Complete; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Biomarkers, Tumor - metabolism Cell Line, Tumor Cell Lineage Humans Minireview Models, Biological Neuroblastoma - genetics Neuroblastoma - pathology Phenotype |
| title | An overview of neuroblastoma cell lineage phenotypes and in vitro models |
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