Antileishmanial Chemotherapy through Clemastine Fumarate Mediated Inhibition of the Leishmania Inositol Phosphorylceramide Synthase

Current chemotherapeutics for leishmaniasis have multiple deficiencies, and there is a need for new safe, efficacious, and affordable medicines. This study describes a successful drug repurposing approach that identifies the over-the-counter antihistamine, clemastine fumarate, as a potential antilei...

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Veröffentlicht in:	ACS infectious diseases 2021-01, Vol.7 (1), p.47-63
Hauptverfasser:	Mina, John G M, Charlton, Rebecca L, Alpizar-Sosa, Edubiel, Escrivani, Douglas O, Brown, Christopher, Alqaisi, Amjed, Borsodi, Maria Paula G, Figueiredo, Claudia P, de Lima, Emanuelle V, Dickie, Emily A, Wei, Wenbin, Coutinho-Silva, Robson, Merritt, Andy, Smith, Terry K, Barrett, Michael P, Rossi-Bergmann, Bartira, Denny, Paul W, Steel, Patrick G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiprotozoal Agents - pharmacology Clemastine - therapeutic use Inositol Leishmaniasis - drug therapy Mice Pharmaceutical Preparations
Online-Zugang:	Volltext
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