Branched-chain amino acid metabolism, insulin sensitivity and liver fat response to exercise training in sedentary dysglycaemic and normoglycaemic men

Aims/hypothesis Obesity and insulin resistance may be associated with elevated plasma concentration of branched-chain amino acids (BCAAs) and impaired BCAA metabolism. However, it is unknown whether the insulin-sensitising effect of long-term exercise can be explained by concomitant change in BCAAs...

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Veröffentlicht in:	Diabetologia 2021-02, Vol.64 (2), p.410-423
Hauptverfasser:	Lee, Sindre, Gulseth, Hanne L., Langleite, Torgrim M., Norheim, Frode, Olsen, Thomas, Refsum, Helga, Jensen, Jørgen, Birkeland, Kåre I., Drevon, Christian A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Adipose Tissue - diagnostic imaging Adipose Tissue - metabolism Adipose Tissue - pathology Amino acids Amino Acids, Branched-Chain - metabolism Body composition Body fat Body weight Diabetes Endurance Training Exercise Gene expression Glucose Clamp Technique Glucose Metabolism Disorders - metabolism Glucose Metabolism Disorders - therapy High-performance liquid chromatography Human Physiology Humans Insulin Insulin Resistance Internal Medicine Isoleucine Kinases Liver Liver - diagnostic imaging Liver - metabolism Magnetic Resonance Imaging Male Medicine Medicine & Public Health Mens health Metabolic Diseases Metabolism Metabolites Middle Aged Mitochondria Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Overweight Overweight - metabolism Overweight - therapy Oxygen Consumption Physical training Plasma Resistance Training Sedentary Behavior Skeletal muscle Spectroscopy Subcutaneous Fat - metabolism Subcutaneous Fat - pathology
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