Absolute Lymphocytes, Ferritin, C-Reactive Protein, and Lactate Dehydrogenase Predict Early Invasive Ventilation in Patients With COVID-19
Abstract Objective Early detection of patients with COVID-19 who will need mechanical invasive ventilation (MIV) may aid in delivering proper care and optimizing the use of limited resources. Methods In this single-center retrospective observational study, we aimed to identify simple laboratory para...
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| Veröffentlicht in: | Laboratory medicine 2021-03, Vol.52 (2), p.141-145 |
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| creator | Payán-Pernía, Salvador Gómez Pérez, Lucía Remacha Sevilla, Ángel F Sierra Gil, Jordi Novelli Canales, Silvana |
| description | Abstract
Objective
Early detection of patients with COVID-19 who will need mechanical invasive ventilation (MIV) may aid in delivering proper care and optimizing the use of limited resources.
Methods
In this single-center retrospective observational study, we aimed to identify simple laboratory parameters that in combination with ferritin (a surrogate marker of severe inflammation) may help predict early (first 48 hours) MIV. A total of 160 patients with COVID-19 in whom serum ferritin, absolute lymphocyte count (ALC), platelet count, C-reactive protein (CRP), and lactate dehydrogenase (LDH) had been analyzed at admission were included.
Results
We found that ferritin, LDH, ALC, and CRP predicted with 88% accuracy the probability of early MIV. Results indicated that LDH showed the greater area under the curve (AUC), with a value of 89.1%. Using the AUC, we established cutoff values for clinical application. Finally, we developed a classification tree based on LDH for its clinical use.
Conclusion
Ferritin, LDH, ALC, and CRP predict with 88% accuracy the probability of early MIV. |
| doi_str_mv | 10.1093/labmed/lmaa105 |
| format | Article |
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Objective
Early detection of patients with COVID-19 who will need mechanical invasive ventilation (MIV) may aid in delivering proper care and optimizing the use of limited resources.
Methods
In this single-center retrospective observational study, we aimed to identify simple laboratory parameters that in combination with ferritin (a surrogate marker of severe inflammation) may help predict early (first 48 hours) MIV. A total of 160 patients with COVID-19 in whom serum ferritin, absolute lymphocyte count (ALC), platelet count, C-reactive protein (CRP), and lactate dehydrogenase (LDH) had been analyzed at admission were included.
Results
We found that ferritin, LDH, ALC, and CRP predicted with 88% accuracy the probability of early MIV. Results indicated that LDH showed the greater area under the curve (AUC), with a value of 89.1%. Using the AUC, we established cutoff values for clinical application. Finally, we developed a classification tree based on LDH for its clinical use.
Conclusion
Ferritin, LDH, ALC, and CRP predict with 88% accuracy the probability of early MIV.</description><identifier>ISSN: 0007-5027</identifier><identifier>EISSN: 1943-7730</identifier><identifier>DOI: 10.1093/labmed/lmaa105</identifier><identifier>PMID: 33336243</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Acute respiratory distress syndrome ; Adult ; Aged ; Analysis ; Biomarkers - blood ; C-reactive protein ; C-Reactive Protein - metabolism ; Coronaviruses ; COVID-19 ; COVID-19 - blood ; COVID-19 - therapy ; Dehydrogenases ; Female ; Ferritin ; Ferritins - blood ; Humans ; L-Lactate Dehydrogenase - blood ; Logistic Models ; Lymphocyte Count ; Lymphocytes ; Male ; Medical research ; Medicine, Experimental ; Middle Aged ; Respiration, Artificial - statistics & numerical data ; Retrospective Studies ; Science ; Ventilation ; Young Adult</subject><ispartof>Laboratory medicine, 2021-03, Vol.52 (2), p.141-145</ispartof><rights>American Society for Clinical Pathology 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2020</rights><rights>American Society for Clinical Pathology 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><rights>COPYRIGHT 2021 Oxford University Press</rights><rights>American Society for Clinical Pathology 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c547t-a3cbbe9d797cbfa16d746c9dbc6536b15a9e15da6ac46cd9751cbef9922045d83</citedby><cites>FETCH-LOGICAL-c547t-a3cbbe9d797cbfa16d746c9dbc6536b15a9e15da6ac46cd9751cbef9922045d83</cites><orcidid>0000-0002-4288-7362</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,1584,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33336243$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Payán-Pernía, Salvador</creatorcontrib><creatorcontrib>Gómez Pérez, Lucía</creatorcontrib><creatorcontrib>Remacha Sevilla, Ángel F</creatorcontrib><creatorcontrib>Sierra Gil, Jordi</creatorcontrib><creatorcontrib>Novelli Canales, Silvana</creatorcontrib><title>Absolute Lymphocytes, Ferritin, C-Reactive Protein, and Lactate Dehydrogenase Predict Early Invasive Ventilation in Patients With COVID-19</title><title>Laboratory medicine</title><addtitle>Lab Med</addtitle><description>Abstract
Objective
Early detection of patients with COVID-19 who will need mechanical invasive ventilation (MIV) may aid in delivering proper care and optimizing the use of limited resources.
Methods
In this single-center retrospective observational study, we aimed to identify simple laboratory parameters that in combination with ferritin (a surrogate marker of severe inflammation) may help predict early (first 48 hours) MIV. A total of 160 patients with COVID-19 in whom serum ferritin, absolute lymphocyte count (ALC), platelet count, C-reactive protein (CRP), and lactate dehydrogenase (LDH) had been analyzed at admission were included.
Results
We found that ferritin, LDH, ALC, and CRP predicted with 88% accuracy the probability of early MIV. Results indicated that LDH showed the greater area under the curve (AUC), with a value of 89.1%. Using the AUC, we established cutoff values for clinical application. Finally, we developed a classification tree based on LDH for its clinical use.
Conclusion
Ferritin, LDH, ALC, and CRP predict with 88% accuracy the probability of early MIV.</description><subject>Acute respiratory distress syndrome</subject><subject>Adult</subject><subject>Aged</subject><subject>Analysis</subject><subject>Biomarkers - blood</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - metabolism</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 - blood</subject><subject>COVID-19 - therapy</subject><subject>Dehydrogenases</subject><subject>Female</subject><subject>Ferritin</subject><subject>Ferritins - blood</subject><subject>Humans</subject><subject>L-Lactate Dehydrogenase - blood</subject><subject>Logistic Models</subject><subject>Lymphocyte Count</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Middle Aged</subject><subject>Respiration, Artificial - statistics & numerical data</subject><subject>Retrospective Studies</subject><subject>Science</subject><subject>Ventilation</subject><subject>Young Adult</subject><issn>0007-5027</issn><issn>1943-7730</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFUl1rFDEUHUSxa_XVRwn4otBpk_lINi_Csm11YaFFtD6GTHJnN2UmWZPMwvwFf7UZdq0fFEwekpx7zsm9l5tlrwk-J5iXF51setAXXS8lwfWTbEZ4VeaMlfhpNsMYs7zGBTvJXoRwn54Vp8Xz7KRMixZVOct-LJrguiECWo_9buvUGCGcoWvw3kRjz9Ay_wxSRbMHdOtdhAmTVqN1AmWSXcJ21N5twMowUUAbFdGV9N2IVnYvw6S8AxtNJ6NxFhmLbtMtIQF9M3GLljd3q8uc8JfZs1Z2AV4dz9Ps6_XVl-WnfH3zcbVcrHNVVyzmslRNA1wzzlTTSkI1q6jiulG0LmlDasmB1FpSqRKuOauJaqDlvChwVet5eZp9OPjuhql3KmXiZSd23vTSj8JJI_6OWLMVG7cXjPE5n9Nk8O5o4N33AUIUvQkKuk5acEMQRcVIRVlRk0R9-w_13g3epvJECs9pSr1gv1kb2YEwtnXpXzWZigXllBHMysnr_BFW2hp6o5yF1iT8MYHyLgQP7UONBItpesRhesRxepLgzZ-deaD_GpdEeH8guGH3P7OfXAPRRw</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Payán-Pernía, Salvador</creator><creator>Gómez Pérez, Lucía</creator><creator>Remacha Sevilla, Ángel F</creator><creator>Sierra Gil, Jordi</creator><creator>Novelli Canales, Silvana</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4288-7362</orcidid></search><sort><creationdate>20210301</creationdate><title>Absolute Lymphocytes, Ferritin, C-Reactive Protein, and Lactate Dehydrogenase Predict Early Invasive Ventilation in Patients With COVID-19</title><author>Payán-Pernía, Salvador ; Gómez Pérez, Lucía ; Remacha Sevilla, Ángel F ; Sierra Gil, Jordi ; Novelli Canales, Silvana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c547t-a3cbbe9d797cbfa16d746c9dbc6536b15a9e15da6ac46cd9751cbef9922045d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acute respiratory distress syndrome</topic><topic>Adult</topic><topic>Aged</topic><topic>Analysis</topic><topic>Biomarkers - blood</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - metabolism</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>COVID-19 - blood</topic><topic>COVID-19 - therapy</topic><topic>Dehydrogenases</topic><topic>Female</topic><topic>Ferritin</topic><topic>Ferritins - blood</topic><topic>Humans</topic><topic>L-Lactate Dehydrogenase - blood</topic><topic>Logistic Models</topic><topic>Lymphocyte Count</topic><topic>Lymphocytes</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Middle Aged</topic><topic>Respiration, Artificial - statistics & numerical data</topic><topic>Retrospective Studies</topic><topic>Science</topic><topic>Ventilation</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Payán-Pernía, Salvador</creatorcontrib><creatorcontrib>Gómez Pérez, Lucía</creatorcontrib><creatorcontrib>Remacha Sevilla, Ángel F</creatorcontrib><creatorcontrib>Sierra Gil, Jordi</creatorcontrib><creatorcontrib>Novelli Canales, Silvana</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Laboratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Payán-Pernía, Salvador</au><au>Gómez Pérez, Lucía</au><au>Remacha Sevilla, Ángel F</au><au>Sierra Gil, Jordi</au><au>Novelli Canales, Silvana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Absolute Lymphocytes, Ferritin, C-Reactive Protein, and Lactate Dehydrogenase Predict Early Invasive Ventilation in Patients With COVID-19</atitle><jtitle>Laboratory medicine</jtitle><addtitle>Lab Med</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>52</volume><issue>2</issue><spage>141</spage><epage>145</epage><pages>141-145</pages><issn>0007-5027</issn><eissn>1943-7730</eissn><abstract>Abstract
Objective
Early detection of patients with COVID-19 who will need mechanical invasive ventilation (MIV) may aid in delivering proper care and optimizing the use of limited resources.
Methods
In this single-center retrospective observational study, we aimed to identify simple laboratory parameters that in combination with ferritin (a surrogate marker of severe inflammation) may help predict early (first 48 hours) MIV. A total of 160 patients with COVID-19 in whom serum ferritin, absolute lymphocyte count (ALC), platelet count, C-reactive protein (CRP), and lactate dehydrogenase (LDH) had been analyzed at admission were included.
Results
We found that ferritin, LDH, ALC, and CRP predicted with 88% accuracy the probability of early MIV. Results indicated that LDH showed the greater area under the curve (AUC), with a value of 89.1%. Using the AUC, we established cutoff values for clinical application. Finally, we developed a classification tree based on LDH for its clinical use.
Conclusion
Ferritin, LDH, ALC, and CRP predict with 88% accuracy the probability of early MIV.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>33336243</pmid><doi>10.1093/labmed/lmaa105</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-4288-7362</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acute respiratory distress syndrome Adult Aged Analysis Biomarkers - blood C-reactive protein C-Reactive Protein - metabolism Coronaviruses COVID-19 COVID-19 - blood COVID-19 - therapy Dehydrogenases Female Ferritin Ferritins - blood Humans L-Lactate Dehydrogenase - blood Logistic Models Lymphocyte Count Lymphocytes Male Medical research Medicine, Experimental Middle Aged Respiration, Artificial - statistics & numerical data Retrospective Studies Science Ventilation Young Adult |
| title | Absolute Lymphocytes, Ferritin, C-Reactive Protein, and Lactate Dehydrogenase Predict Early Invasive Ventilation in Patients With COVID-19 |
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