The clinical research of 5 steps sequential method for whole treatment of hemorrhagic radiation cystitis in china
Curing hemorrhagic cystitis remains a challenge. We explore a continuous and effective treatment for hemorrhagic radiation cystitis. The data of patients in 6 provincial cancer hospital urology departments between April 2015 and December 2019 was reviewed retrospectively. Patients were classified as...
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| Veröffentlicht in: | International journal of medical sciences 2021, Vol.18 (3), p.756-762 |
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| creator | Ju, Zhenghua Yu, Wenchang Li, Youyuan Han, Weiqing Tu, Xinhua Zhu, Shaoxing Zou, Qing |
| description | Curing hemorrhagic cystitis remains a challenge. We explore a continuous and effective treatment for hemorrhagic radiation cystitis.
The data of patients in 6 provincial cancer hospital urology departments between April 2015 and December 2019 was reviewed retrospectively. Patients were classified as moderate and severe groups. The 5-steps sequential method was adopted. Two groups were initiated with step 1 and step 3 respectively. Step 1 was symptomatic treatment. Thrombin solution or sodium hyaluronate was administrated for bladder irrigation in step 2. Step 3 was transurethral electrocoagulation. Step 4 was interventional embolization. Step 5 was HBO therapy. OABSS was used to assess the improvement of patients' symptoms. The outcome was evaluated after at least 6 months of follow-up.
A total of 650 patients (56 men and 594 women), mean age 71.2 years, were enrolled in the 5 steps sequential method. 582 patients were classified as moderate and 68 severe group. In moderate group, the cure rate of step 1 was 61.2% (356/582), 80.4% (468/582) after step 2, 93.1% (542/582) after step 3, 96.2% (560/582) after step 4, and 99.8% (581/582) after step 5. In severe group, the cure rate was 54.4% (37/68) after step 3, 76.5% (52/68) after step 4, and 94.1% (64/68) after the step 5 respectively. The mean OABSS scores of both groups significantly decreased after 5 steps sequential method treatment (P |
| doi_str_mv | 10.7150/ijms.47906 |
| format | Article |
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The data of patients in 6 provincial cancer hospital urology departments between April 2015 and December 2019 was reviewed retrospectively. Patients were classified as moderate and severe groups. The 5-steps sequential method was adopted. Two groups were initiated with step 1 and step 3 respectively. Step 1 was symptomatic treatment. Thrombin solution or sodium hyaluronate was administrated for bladder irrigation in step 2. Step 3 was transurethral electrocoagulation. Step 4 was interventional embolization. Step 5 was HBO therapy. OABSS was used to assess the improvement of patients' symptoms. The outcome was evaluated after at least 6 months of follow-up.
A total of 650 patients (56 men and 594 women), mean age 71.2 years, were enrolled in the 5 steps sequential method. 582 patients were classified as moderate and 68 severe group. In moderate group, the cure rate of step 1 was 61.2% (356/582), 80.4% (468/582) after step 2, 93.1% (542/582) after step 3, 96.2% (560/582) after step 4, and 99.8% (581/582) after step 5. In severe group, the cure rate was 54.4% (37/68) after step 3, 76.5% (52/68) after step 4, and 94.1% (64/68) after the step 5 respectively. The mean OABSS scores of both groups significantly decreased after 5 steps sequential method treatment (P<0.01).
Our results show hemorrhagic radiation cystitis can be cured in 5 steps, and the 5 steps sequential method is welcomed and effective. Therapy efficacy depends on the number of steps adopted and the severity of hematuria.</description><identifier>ISSN: 1449-1907</identifier><identifier>EISSN: 1449-1907</identifier><identifier>DOI: 10.7150/ijms.47906</identifier><identifier>PMID: 33437210</identifier><language>eng</language><publisher>Australia: Ivyspring International Publisher Pty Ltd</publisher><subject>Bladder ; Cancer therapies ; Embolization ; Hematuria ; Hemoglobin ; Patients ; Radiation therapy ; Remission (Medicine) ; Research Paper ; Urine</subject><ispartof>International journal of medical sciences, 2021, Vol.18 (3), p.756-762</ispartof><rights>The author(s).</rights><rights>2021. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The author(s) 2021</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-b7e76cd2cec0a6b428c2443fb636ae09b31af7b2edb5384d05ed5e015fc374493</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797551/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797551/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33437210$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ju, Zhenghua</creatorcontrib><creatorcontrib>Yu, Wenchang</creatorcontrib><creatorcontrib>Li, Youyuan</creatorcontrib><creatorcontrib>Han, Weiqing</creatorcontrib><creatorcontrib>Tu, Xinhua</creatorcontrib><creatorcontrib>Zhu, Shaoxing</creatorcontrib><creatorcontrib>Zou, Qing</creatorcontrib><title>The clinical research of 5 steps sequential method for whole treatment of hemorrhagic radiation cystitis in china</title><title>International journal of medical sciences</title><addtitle>Int J Med Sci</addtitle><description>Curing hemorrhagic cystitis remains a challenge. We explore a continuous and effective treatment for hemorrhagic radiation cystitis.
The data of patients in 6 provincial cancer hospital urology departments between April 2015 and December 2019 was reviewed retrospectively. Patients were classified as moderate and severe groups. The 5-steps sequential method was adopted. Two groups were initiated with step 1 and step 3 respectively. Step 1 was symptomatic treatment. Thrombin solution or sodium hyaluronate was administrated for bladder irrigation in step 2. Step 3 was transurethral electrocoagulation. Step 4 was interventional embolization. Step 5 was HBO therapy. OABSS was used to assess the improvement of patients' symptoms. The outcome was evaluated after at least 6 months of follow-up.
A total of 650 patients (56 men and 594 women), mean age 71.2 years, were enrolled in the 5 steps sequential method. 582 patients were classified as moderate and 68 severe group. In moderate group, the cure rate of step 1 was 61.2% (356/582), 80.4% (468/582) after step 2, 93.1% (542/582) after step 3, 96.2% (560/582) after step 4, and 99.8% (581/582) after step 5. In severe group, the cure rate was 54.4% (37/68) after step 3, 76.5% (52/68) after step 4, and 94.1% (64/68) after the step 5 respectively. The mean OABSS scores of both groups significantly decreased after 5 steps sequential method treatment (P<0.01).
Our results show hemorrhagic radiation cystitis can be cured in 5 steps, and the 5 steps sequential method is welcomed and effective. Therapy efficacy depends on the number of steps adopted and the severity of hematuria.</description><subject>Bladder</subject><subject>Cancer therapies</subject><subject>Embolization</subject><subject>Hematuria</subject><subject>Hemoglobin</subject><subject>Patients</subject><subject>Radiation therapy</subject><subject>Remission (Medicine)</subject><subject>Research Paper</subject><subject>Urine</subject><issn>1449-1907</issn><issn>1449-1907</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpVUU1LAzEQDaJYrV78ARLwJlSTTbLpXgQpfkHBSz2HbHa2m7K7aZNU6b83tbXoaQbemzdv5iF0RcmdpILc20UX7rgsSH6EzijnxYgWRB7_6QfoPIQFISxjkp6iAWOcyYySM7SaNYBNa3trdIs9BNDeNNjVWOAQYRlwgNUa-mgT3EFsXIVr5_FX41rA0YOOXUK3Aw10zvtGz63BXldWR-t6bDYh2mgDtqlvbK8v0Emt2wCX-zpEH89Ps8nraPr-8jZ5nI4MJ3kclRJkbqrMgCE6L3k2NhnnrC5zlmsgRcmormWZQVUKNuYVEVAJIFTUhsl0Nxuih53ucl12UJnk0utWLb3ttN8op636j_S2UXP3qaQspBA0CdzsBbxLLwhRLdza98mzykQxzmTBxzKxbncs410IHurDBkrUNh61jUf9xJPI1389Hai_ebBvLW6Otw</recordid><startdate>2021</startdate><enddate>2021</enddate><creator>Ju, Zhenghua</creator><creator>Yu, Wenchang</creator><creator>Li, Youyuan</creator><creator>Han, Weiqing</creator><creator>Tu, Xinhua</creator><creator>Zhu, Shaoxing</creator><creator>Zou, Qing</creator><general>Ivyspring International Publisher Pty Ltd</general><general>Ivyspring International Publisher</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>2021</creationdate><title>The clinical research of 5 steps sequential method for whole treatment of hemorrhagic radiation cystitis in china</title><author>Ju, Zhenghua ; Yu, Wenchang ; Li, Youyuan ; Han, Weiqing ; Tu, Xinhua ; Zhu, Shaoxing ; Zou, Qing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-b7e76cd2cec0a6b428c2443fb636ae09b31af7b2edb5384d05ed5e015fc374493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Bladder</topic><topic>Cancer therapies</topic><topic>Embolization</topic><topic>Hematuria</topic><topic>Hemoglobin</topic><topic>Patients</topic><topic>Radiation therapy</topic><topic>Remission (Medicine)</topic><topic>Research Paper</topic><topic>Urine</topic><toplevel>online_resources</toplevel><creatorcontrib>Ju, Zhenghua</creatorcontrib><creatorcontrib>Yu, Wenchang</creatorcontrib><creatorcontrib>Li, Youyuan</creatorcontrib><creatorcontrib>Han, Weiqing</creatorcontrib><creatorcontrib>Tu, Xinhua</creatorcontrib><creatorcontrib>Zhu, Shaoxing</creatorcontrib><creatorcontrib>Zou, Qing</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ju, Zhenghua</au><au>Yu, Wenchang</au><au>Li, Youyuan</au><au>Han, Weiqing</au><au>Tu, Xinhua</au><au>Zhu, Shaoxing</au><au>Zou, Qing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The clinical research of 5 steps sequential method for whole treatment of hemorrhagic radiation cystitis in china</atitle><jtitle>International journal of medical sciences</jtitle><addtitle>Int J Med Sci</addtitle><date>2021</date><risdate>2021</risdate><volume>18</volume><issue>3</issue><spage>756</spage><epage>762</epage><pages>756-762</pages><issn>1449-1907</issn><eissn>1449-1907</eissn><abstract>Curing hemorrhagic cystitis remains a challenge. We explore a continuous and effective treatment for hemorrhagic radiation cystitis.
The data of patients in 6 provincial cancer hospital urology departments between April 2015 and December 2019 was reviewed retrospectively. Patients were classified as moderate and severe groups. The 5-steps sequential method was adopted. Two groups were initiated with step 1 and step 3 respectively. Step 1 was symptomatic treatment. Thrombin solution or sodium hyaluronate was administrated for bladder irrigation in step 2. Step 3 was transurethral electrocoagulation. Step 4 was interventional embolization. Step 5 was HBO therapy. OABSS was used to assess the improvement of patients' symptoms. The outcome was evaluated after at least 6 months of follow-up.
A total of 650 patients (56 men and 594 women), mean age 71.2 years, were enrolled in the 5 steps sequential method. 582 patients were classified as moderate and 68 severe group. In moderate group, the cure rate of step 1 was 61.2% (356/582), 80.4% (468/582) after step 2, 93.1% (542/582) after step 3, 96.2% (560/582) after step 4, and 99.8% (581/582) after step 5. In severe group, the cure rate was 54.4% (37/68) after step 3, 76.5% (52/68) after step 4, and 94.1% (64/68) after the step 5 respectively. The mean OABSS scores of both groups significantly decreased after 5 steps sequential method treatment (P<0.01).
Our results show hemorrhagic radiation cystitis can be cured in 5 steps, and the 5 steps sequential method is welcomed and effective. Therapy efficacy depends on the number of steps adopted and the severity of hematuria.</abstract><cop>Australia</cop><pub>Ivyspring International Publisher Pty Ltd</pub><pmid>33437210</pmid><doi>10.7150/ijms.47906</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Bladder Cancer therapies Embolization Hematuria Hemoglobin Patients Radiation therapy Remission (Medicine) Research Paper Urine |
| title | The clinical research of 5 steps sequential method for whole treatment of hemorrhagic radiation cystitis in china |
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