P - cresol and Indoxyl Sulfate Impair Osteogenic Differentiation by Triggering Mesenchymal Stem Cell Senescence

Chronic kidney disease (CKD) patients obtained high levels of uremic toxins progressively develop several complications including bone fractures. Protein-bound uremic toxins especially p-cresol and indoxyl sulfate are hardly eliminated due to their high molecular weight. Thus, the abnormality of bon...

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Veröffentlicht in:	International journal of medical sciences 2021, Vol.18 (3), p.744-755
Hauptverfasser:	Kamprom, Witchayapon, Tawonsawatruk, Tulyapruek, Mas-Oodi, Sumana, Anansilp, Korrarit, Rattanasompattikul, Manoch, Supokawej, Aungkura
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia Bone marrow Cardiovascular disease Cyclin-dependent kinases Gene expression Hemodialysis Kinases Metabolism Molecular weight Oxidative stress Patients Penicillin Phosphatase Proteins Research Paper Senescence Stem cells Toxins
Online-Zugang:	Volltext
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