Single-molecule visualization of human RECQ5 interactions with single-stranded DNA recombination intermediates

Abstract RECQ5 is one of five RecQ helicases found in humans and is thought to participate in homologous DNA recombination by acting as a negative regulator of the recombinase protein RAD51. Here, we use kinetic and single molecule imaging methods to monitor RECQ5 behavior on various nucleoprotein c...

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Veröffentlicht in:	Nucleic acids research 2021-01, Vol.49 (1), p.285-305
Hauptverfasser:	Xue, Chaoyou, Molnarova, Lucia, Steinfeld, Justin B, Zhao, Weixing, Ma, Chujian, Spirek, Mario, Kaniecki, Kyle, Kwon, Youngho, Beláň, Ondrej, Krejci, Katerina, Boulton, Simon J, Sung, Patrick, Greene, Eric C, Krejci, Lumir
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism DNA, Single-Stranded - metabolism DNA, Single-Stranded - ultrastructure Genome Integrity, Repair and Homologous Recombination Humans Hydrolysis Kinetics Microscopy, Atomic Force Molecular Motor Proteins - metabolism Molecular Motor Proteins - ultrastructure Mutation, Missense Point Mutation Rad51 Recombinase - genetics Rad51 Recombinase - metabolism Recombinant Fusion Proteins - metabolism Recombinant Proteins - metabolism RecQ Helicases - genetics RecQ Helicases - metabolism RecQ Helicases - ultrastructure Replication Protein A - metabolism Single Molecule Imaging Substrate Specificity
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