Discovery and clinical translation of novel glaucoma biomarkers
Glaucoma and other optic neuropathies are characterized by progressive dysfunction and loss of retinal ganglion cells and their axons. Given the high prevalence of glaucoma-related blindness and the availability of treatment options, improving the diagnosis and precise monitoring of progression in t...
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| Veröffentlicht in: | Progress in retinal and eye research 2021-01, Vol.80, p.100875-100875, Article 100875 |
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| container_title | Progress in retinal and eye research |
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| creator | Beykin, Gala Norcia, Anthony M. Srinivasan, Vivek J. Dubra, Alfredo Goldberg, Jeffrey L. |
| description | Glaucoma and other optic neuropathies are characterized by progressive dysfunction and loss of retinal ganglion cells and their axons. Given the high prevalence of glaucoma-related blindness and the availability of treatment options, improving the diagnosis and precise monitoring of progression in these conditions is paramount. Here we review recent progress in the development of novel biomarkers for glaucoma in the context of disease pathophysiology and we propose future steps for the field, including integration of exploratory biomarker outcomes into prospective therapeutic trials. We anticipate that, when validated, some of the novel glaucoma biomarkers discussed here will prove useful for clinical diagnosis and prediction of progression, as well as monitoring of clinical responses to standard and investigational therapies. |
| doi_str_mv | 10.1016/j.preteyeres.2020.100875 |
| format | Article |
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| ispartof | Progress in retinal and eye research, 2021-01, Vol.80, p.100875-100875, Article 100875 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Axonal degeneration Axons - pathology Biomarkers - metabolism Disease Models, Animal Glaucoma Glaucoma - metabolism Glaucoma - physiopathology Humans Nerve fiber layer Optic Nerve Diseases - metabolism Optic Nerve Diseases - physiopathology Retinal ganglion cell Retinal Ganglion Cells - pathology Retinal imaging |
| title | Discovery and clinical translation of novel glaucoma biomarkers |
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