Human Stem Cell-Derived Neurons Repair Circuits and Restore Neural Function

Although cell transplantation can rescue motor defects in Parkinson’s disease (PD) models, whether and how grafts functionally repair damaged neural circuitry in the adult brain is not known. We transplanted hESC-derived midbrain dopamine (mDA) or cortical glutamate neurons into the substantia nigra...

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Veröffentlicht in:	Cell stem cell 2021-01, Vol.28 (1), p.112-126.e6
Hauptverfasser:	Xiong, Man, Tao, Yezheng, Gao, Qinqin, Feng, Ban, Yan, Wei, Zhou, Yingying, Kotsonis, Thomas A., Yuan, Tingli, You, Zhiwen, Wu, Ziyan, Xi, Jiajie, Haberman, Alexander, Graham, Julia, Block, Jasper, Zhou, Wenhao, Chen, Yuejun, Zhang, Su-Chun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals circuit repair Dopamine dopamine neuron Dopaminergic Neurons graft integration human pluripotent stem cells Humans Mesencephalon neural regeneration Neurons Parkinson Disease - therapy Parkinson's disease stem cell therapy Substantia Nigra
Online-Zugang:	Volltext
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