Statistical Modelling of the Visual Impact of Subretinal Fluid and Associated Features
Introduction The aim of this study was to develop a statistical model to determine the visual significance of subretinal fluid (SRF) in combination with other constructed optical coherence tomography (OCT) features in patients with wet age-related macular degeneration. Methods The project used label...
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| Veröffentlicht in: | Ophthalmology and Therapy 2021-03, Vol.10 (1), p.127-135 |
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| creator | Aslam, Tariq M. Mahmood, Sajjad Balaskas, Konstantinos Hoyle, David C. |
| description | Introduction
The aim of this study was to develop a statistical model to determine the visual significance of subretinal fluid (SRF) in combination with other constructed optical coherence tomography (OCT) features in patients with wet age-related macular degeneration.
Methods
The project used labelled data from 1211 OCTs of patients with neovascular macular degeneration (nAMD) attending the macular treatment centre of Manchester Royal Eye Hospital to build a statistical model to determine vision for any virtual, constructed OCT. A four-dimensional plot was created to represent the visual impact of SRF in OCTs in the context of the associated OCT characteristics of atrophy and subretinal hyperreflective material (SHRM).
Results
The plot illustrates that at levels of SRF below 150 µm, the impact of SRF on vision is very low. Increasing the amount of fluid to 200 µm and beyond increases the impact on vision, but only if there is little atrophy or SHRM.
Conclusions
This study suggests that levels of SRF up to around 150 µm thickness on OCT have minimal impact on vision. Greater levels of SRF have greater impact on vision, unless associated with significant amounts of atrophy or SHRM, when the additional effect of the SRF on vision remains low. |
| doi_str_mv | 10.1007/s40123-020-00327-w |
| format | Article |
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The aim of this study was to develop a statistical model to determine the visual significance of subretinal fluid (SRF) in combination with other constructed optical coherence tomography (OCT) features in patients with wet age-related macular degeneration.
Methods
The project used labelled data from 1211 OCTs of patients with neovascular macular degeneration (nAMD) attending the macular treatment centre of Manchester Royal Eye Hospital to build a statistical model to determine vision for any virtual, constructed OCT. A four-dimensional plot was created to represent the visual impact of SRF in OCTs in the context of the associated OCT characteristics of atrophy and subretinal hyperreflective material (SHRM).
Results
The plot illustrates that at levels of SRF below 150 µm, the impact of SRF on vision is very low. Increasing the amount of fluid to 200 µm and beyond increases the impact on vision, but only if there is little atrophy or SHRM.
Conclusions
This study suggests that levels of SRF up to around 150 µm thickness on OCT have minimal impact on vision. Greater levels of SRF have greater impact on vision, unless associated with significant amounts of atrophy or SHRM, when the additional effect of the SRF on vision remains low.</description><identifier>ISSN: 2193-8245</identifier><identifier>EISSN: 2193-6528</identifier><identifier>DOI: 10.1007/s40123-020-00327-w</identifier><identifier>PMID: 33420953</identifier><language>eng</language><publisher>Cheshire: Springer Healthcare</publisher><subject>Aqueous humor ; Development and progression ; Health aspects ; Internal Medicine ; Macular degeneration ; Measurement ; Medicine ; Medicine & Public Health ; Ophthalmology ; Original Research ; Risk factors ; Vision disorders</subject><ispartof>Ophthalmology and Therapy, 2021-03, Vol.10 (1), p.127-135</ispartof><rights>The Author(s) 2021</rights><rights>COPYRIGHT 2021 Springer</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c513t-16a3caa2a9f72b02eb6d0e2182369b8d334a7fcc2fea9472f450f78fcf54783f3</citedby><cites>FETCH-LOGICAL-c513t-16a3caa2a9f72b02eb6d0e2182369b8d334a7fcc2fea9472f450f78fcf54783f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796679/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796679/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27922,27923,41118,42187,51574,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33420953$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aslam, Tariq M.</creatorcontrib><creatorcontrib>Mahmood, Sajjad</creatorcontrib><creatorcontrib>Balaskas, Konstantinos</creatorcontrib><creatorcontrib>Hoyle, David C.</creatorcontrib><title>Statistical Modelling of the Visual Impact of Subretinal Fluid and Associated Features</title><title>Ophthalmology and Therapy</title><addtitle>Ophthalmol Ther</addtitle><addtitle>Ophthalmol Ther</addtitle><description>Introduction
The aim of this study was to develop a statistical model to determine the visual significance of subretinal fluid (SRF) in combination with other constructed optical coherence tomography (OCT) features in patients with wet age-related macular degeneration.
Methods
The project used labelled data from 1211 OCTs of patients with neovascular macular degeneration (nAMD) attending the macular treatment centre of Manchester Royal Eye Hospital to build a statistical model to determine vision for any virtual, constructed OCT. A four-dimensional plot was created to represent the visual impact of SRF in OCTs in the context of the associated OCT characteristics of atrophy and subretinal hyperreflective material (SHRM).
Results
The plot illustrates that at levels of SRF below 150 µm, the impact of SRF on vision is very low. Increasing the amount of fluid to 200 µm and beyond increases the impact on vision, but only if there is little atrophy or SHRM.
Conclusions
This study suggests that levels of SRF up to around 150 µm thickness on OCT have minimal impact on vision. Greater levels of SRF have greater impact on vision, unless associated with significant amounts of atrophy or SHRM, when the additional effect of the SRF on vision remains low.</description><subject>Aqueous humor</subject><subject>Development and progression</subject><subject>Health aspects</subject><subject>Internal Medicine</subject><subject>Macular degeneration</subject><subject>Measurement</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Ophthalmology</subject><subject>Original Research</subject><subject>Risk factors</subject><subject>Vision disorders</subject><issn>2193-8245</issn><issn>2193-6528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><recordid>eNp9kUtv1TAQhS0EolXpH2CBsmST4reTDdJVxYVKRV30sbUcZ3zrKrEvtkPFv8cllwo2lRe2zpw5Gs-H0HuCzwjG6lPmmFDWYopbjBlV7eMrdExJz1opaPf68O4oF0foNOcHjKu_Ez3nb9ERY5ziXrBjdHddTPG5eGum5nscYZp82DXRNeUemjufl6pfzHtjy5N4vQwJig9V3E6LHxsTxmaTc7TeFBibLZiyJMjv0Btnpgynh_sE3W6_3Jx_ay-vvl6cby5bKwgrLZGGWWOo6Z2iA6YwyBEDJR1lsh-6sc5plLOWOjA9V9RxgZ3qnHWCq445doI-r7n7ZZhhtBBKMpPeJz-b9EtH4_X_leDv9S7-1Er1Uqq-Bnw8BKT4Y4Fc9OyzrVswAeKSNeVKCkm4ZNV6tlp3ZgLtg4s10dYzwuxtDOB81Td1_ViIyqg20LXBpphzAvc8F8H6CaJeIeoKUf-BqB9r04d_f_Tc8hdZNbDVkGsp7CDph7ikSiS_FPsbEbWo_A</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Aslam, Tariq M.</creator><creator>Mahmood, Sajjad</creator><creator>Balaskas, Konstantinos</creator><creator>Hoyle, David C.</creator><general>Springer Healthcare</general><general>Springer</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20210301</creationdate><title>Statistical Modelling of the Visual Impact of Subretinal Fluid and Associated Features</title><author>Aslam, Tariq M. ; Mahmood, Sajjad ; Balaskas, Konstantinos ; Hoyle, David C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c513t-16a3caa2a9f72b02eb6d0e2182369b8d334a7fcc2fea9472f450f78fcf54783f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aqueous humor</topic><topic>Development and progression</topic><topic>Health aspects</topic><topic>Internal Medicine</topic><topic>Macular degeneration</topic><topic>Measurement</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Ophthalmology</topic><topic>Original Research</topic><topic>Risk factors</topic><topic>Vision disorders</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aslam, Tariq M.</creatorcontrib><creatorcontrib>Mahmood, Sajjad</creatorcontrib><creatorcontrib>Balaskas, Konstantinos</creatorcontrib><creatorcontrib>Hoyle, David C.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Ophthalmology and Therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aslam, Tariq M.</au><au>Mahmood, Sajjad</au><au>Balaskas, Konstantinos</au><au>Hoyle, David C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Statistical Modelling of the Visual Impact of Subretinal Fluid and Associated Features</atitle><jtitle>Ophthalmology and Therapy</jtitle><stitle>Ophthalmol Ther</stitle><addtitle>Ophthalmol Ther</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>10</volume><issue>1</issue><spage>127</spage><epage>135</epage><pages>127-135</pages><issn>2193-8245</issn><eissn>2193-6528</eissn><abstract>Introduction
The aim of this study was to develop a statistical model to determine the visual significance of subretinal fluid (SRF) in combination with other constructed optical coherence tomography (OCT) features in patients with wet age-related macular degeneration.
Methods
The project used labelled data from 1211 OCTs of patients with neovascular macular degeneration (nAMD) attending the macular treatment centre of Manchester Royal Eye Hospital to build a statistical model to determine vision for any virtual, constructed OCT. A four-dimensional plot was created to represent the visual impact of SRF in OCTs in the context of the associated OCT characteristics of atrophy and subretinal hyperreflective material (SHRM).
Results
The plot illustrates that at levels of SRF below 150 µm, the impact of SRF on vision is very low. Increasing the amount of fluid to 200 µm and beyond increases the impact on vision, but only if there is little atrophy or SHRM.
Conclusions
This study suggests that levels of SRF up to around 150 µm thickness on OCT have minimal impact on vision. Greater levels of SRF have greater impact on vision, unless associated with significant amounts of atrophy or SHRM, when the additional effect of the SRF on vision remains low.</abstract><cop>Cheshire</cop><pub>Springer Healthcare</pub><pmid>33420953</pmid><doi>10.1007/s40123-020-00327-w</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Springer Nature OA Free Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Aqueous humor Development and progression Health aspects Internal Medicine Macular degeneration Measurement Medicine Medicine & Public Health Ophthalmology Original Research Risk factors Vision disorders |
| title | Statistical Modelling of the Visual Impact of Subretinal Fluid and Associated Features |
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