Fludarabine, High-Dose Cytarabine and Idarubicin-Based Induction May Overcome the Negative Prognostic Impact of FLT3 -ITD in NPM1 Mutated AML, Irrespectively of FLT3 -ITD Allelic Burden

The mutations of and -ITD represent the most frequent genetic aberration in acute myeloid leukemia. Indeed, the presence of an mutation reduces the negative prognostic impact of -ITD in patients treated with conventional "3+7" induction. However, little information is available on their pr...

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Veröffentlicht in:	Cancers 2020-12, Vol.13 (1), p.34
Hauptverfasser:	Minetto, Paola, Candoni, Anna, Guolo, Fabio, Clavio, Marino, Zannier, Maria Elena, Miglino, Maurizio, Dubbini, Maria Vittoria, Carminati, Enrico, Sicuranza, Anna, Ciofini, Sara, Colombo, Nicoletta, Pugliese, Girolamo, Marcolin, Riccardo, Santoni, Adele, Ballerini, Filippo, Lanino, Luca, Cea, Michele, Gobbi, Marco, Bocchia, Monica, Fanin, Renato, Lemoli, Roberto Massimo
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute myeloid leukemia Bone marrow Chemotherapy Cytarabine Fludarabine Hematology Leukemia Linux Medical prognosis Mortality Multivariate analysis Mutation Myeloid leukemia Risk groups Statistical analysis Stem cell transplantation Survival Survival analysis Transplants & implants
Online-Zugang:	Volltext
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