Functional MRI (fMRI) Evaluation of Hyperbaric Oxygen Therapy (HBOT) Efficacy in Chronic Cerebral Stroke: A Small Retrospective Consecutive Case Series
Functional Magnetic Resonance Imaging (fMRI) evaluation of HyberBaric Oxygen Therapy (HBOT) effects on chronic cerebral stroke Patients (Pts). Our aim was to evaluate with fMRI, in a 3 Tesla system, the functional effects of HBOT on the Central Nervous System (CNS) in four Pts with established ischa...
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| Veröffentlicht in: | International journal of environmental research and public health 2020-12, Vol.18 (1), p.190 |
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| creator | Cevolani, Daniela Di Donato, Ferruccio Santarella, Luigi Bertossi, Simone Cellerini, Martino |
| description | Functional Magnetic Resonance Imaging (fMRI) evaluation of HyberBaric Oxygen Therapy (HBOT) effects on chronic cerebral stroke Patients (Pts).
Our aim was to evaluate with fMRI, in a 3 Tesla system, the functional effects of HBOT on the Central Nervous System (CNS) in four Pts with established ischaemic and haemorrhagic cerebral strokes (2 Pts each). To our knowledge, no author used this Magnetic Resonance (MR) technique for this purpose, till now.
All four Pts underwent a fMRI study before and after 40 HBOT sessions, with a time window of a few days. They carried out two language (text listening, silent word-verb generation) and two motor (hand and foot movements) tasks (30 s On-Off block paradigms).
After HBOT, all Pts reported a clinical improvement, mostly concerning language fluency and motor paresis. fMRI analysis demonstrated an increase in both the extent and the statistical significance of most of the examined eloquent areas.
These changes were consistent with the clinical improvement in all Pts, suggesting a possible role of fMRI in revealing neuronal functional correlates of neuronal plasticity and HBOT-related neoangiogenesis. Although only four Pts were examined, fMRI proved to be a sensitive, non-invasive and reliable modality for monitoring neuronal functional changes before and after HBOT. |
| doi_str_mv | 10.3390/ijerph18010190 |
| format | Article |
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Our aim was to evaluate with fMRI, in a 3 Tesla system, the functional effects of HBOT on the Central Nervous System (CNS) in four Pts with established ischaemic and haemorrhagic cerebral strokes (2 Pts each). To our knowledge, no author used this Magnetic Resonance (MR) technique for this purpose, till now.
All four Pts underwent a fMRI study before and after 40 HBOT sessions, with a time window of a few days. They carried out two language (text listening, silent word-verb generation) and two motor (hand and foot movements) tasks (30 s On-Off block paradigms).
After HBOT, all Pts reported a clinical improvement, mostly concerning language fluency and motor paresis. fMRI analysis demonstrated an increase in both the extent and the statistical significance of most of the examined eloquent areas.
These changes were consistent with the clinical improvement in all Pts, suggesting a possible role of fMRI in revealing neuronal functional correlates of neuronal plasticity and HBOT-related neoangiogenesis. Although only four Pts were examined, fMRI proved to be a sensitive, non-invasive and reliable modality for monitoring neuronal functional changes before and after HBOT.</description><identifier>ISSN: 1660-4601</identifier><identifier>ISSN: 1661-7827</identifier><identifier>EISSN: 1660-4601</identifier><identifier>DOI: 10.3390/ijerph18010190</identifier><identifier>PMID: 33383925</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adult ; Aged ; Aphasia ; Brain Ischemia - diagnostic imaging ; Brain Ischemia - therapy ; Brief Report ; Central nervous system ; Consent ; Dysarthria ; Evaluation ; Functional magnetic resonance imaging ; Functional plasticity ; Humans ; Hyperbaric oxygen therapy ; Hyperbaric Oxygenation ; Language ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neuroplasticity ; Outpatient care facilities ; Oxygen therapy ; Paresis ; Patients ; Resonance ; Retrospective Studies ; Software ; Speech therapy ; Stroke ; Stroke - diagnostic imaging ; Stroke - therapy</subject><ispartof>International journal of environmental research and public health, 2020-12, Vol.18 (1), p.190</ispartof><rights>2021. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-815c52fbe686ef925bf6119eca2382d939522f3d736c29537b3b1bab1f7c5d633</citedby><cites>FETCH-LOGICAL-c418t-815c52fbe686ef925bf6119eca2382d939522f3d736c29537b3b1bab1f7c5d633</cites><orcidid>0000-0003-4385-5386</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794810/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794810/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33383925$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cevolani, Daniela</creatorcontrib><creatorcontrib>Di Donato, Ferruccio</creatorcontrib><creatorcontrib>Santarella, Luigi</creatorcontrib><creatorcontrib>Bertossi, Simone</creatorcontrib><creatorcontrib>Cellerini, Martino</creatorcontrib><title>Functional MRI (fMRI) Evaluation of Hyperbaric Oxygen Therapy (HBOT) Efficacy in Chronic Cerebral Stroke: A Small Retrospective Consecutive Case Series</title><title>International journal of environmental research and public health</title><addtitle>Int J Environ Res Public Health</addtitle><description>Functional Magnetic Resonance Imaging (fMRI) evaluation of HyberBaric Oxygen Therapy (HBOT) effects on chronic cerebral stroke Patients (Pts).
Our aim was to evaluate with fMRI, in a 3 Tesla system, the functional effects of HBOT on the Central Nervous System (CNS) in four Pts with established ischaemic and haemorrhagic cerebral strokes (2 Pts each). To our knowledge, no author used this Magnetic Resonance (MR) technique for this purpose, till now.
All four Pts underwent a fMRI study before and after 40 HBOT sessions, with a time window of a few days. They carried out two language (text listening, silent word-verb generation) and two motor (hand and foot movements) tasks (30 s On-Off block paradigms).
After HBOT, all Pts reported a clinical improvement, mostly concerning language fluency and motor paresis. fMRI analysis demonstrated an increase in both the extent and the statistical significance of most of the examined eloquent areas.
These changes were consistent with the clinical improvement in all Pts, suggesting a possible role of fMRI in revealing neuronal functional correlates of neuronal plasticity and HBOT-related neoangiogenesis. Although only four Pts were examined, fMRI proved to be a sensitive, non-invasive and reliable modality for monitoring neuronal functional changes before and after HBOT.</description><subject>Adult</subject><subject>Aged</subject><subject>Aphasia</subject><subject>Brain Ischemia - diagnostic imaging</subject><subject>Brain Ischemia - therapy</subject><subject>Brief Report</subject><subject>Central nervous system</subject><subject>Consent</subject><subject>Dysarthria</subject><subject>Evaluation</subject><subject>Functional magnetic resonance imaging</subject><subject>Functional plasticity</subject><subject>Humans</subject><subject>Hyperbaric oxygen therapy</subject><subject>Hyperbaric Oxygenation</subject><subject>Language</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neuroplasticity</subject><subject>Outpatient care facilities</subject><subject>Oxygen therapy</subject><subject>Paresis</subject><subject>Patients</subject><subject>Resonance</subject><subject>Retrospective Studies</subject><subject>Software</subject><subject>Speech therapy</subject><subject>Stroke</subject><subject>Stroke - diagnostic imaging</subject><subject>Stroke - therapy</subject><issn>1660-4601</issn><issn>1661-7827</issn><issn>1660-4601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkU1v1DAQhi1ERT_gyhFZ4rI9bLEziZNwQGqjlq1UtFJ3OUeOd9z1krWDnayaX8LfxWXbquVij8aP3_l4CfnI2RlAyb6YDfpuzQvGGS_ZG3LEhWDTVDD-9kV8SI5D2DAGRSrKd-QQAAook-yI_LkarOqNs7KlP26v6UTH85Re7mQ7yIc8dZrOxg59I71RdH4_3qGlyzV62Y10MruYLyOutVFSjdRYWq29s5Gs0GPjo-yi9-4XfqXndLGVbUtvMSZCh7HsDmnlbEA17GMZkC7QGwzvyYGWbcAPj_cJ-Xl1uaxm05v59-vq_GaqUl7004JnKkt0g6IQqONEjRacl6hkAkWyKqHMkkTDKgehkjKDvIGGN7LhOlfZSgCckG973W5otrhSaPvYc915s5V-rJ009esXa9b1ndvVeV6mBWdRYPIo4N3vAUNfb01Q2LbSohtCnaR5mrGE_UM__4du3ODj5vdUzlMAHqmzPaXiloJH_dwMZ_WD5_Vrz-OHTy9HeMafTIa_vPqpIw</recordid><startdate>20201229</startdate><enddate>20201229</enddate><creator>Cevolani, Daniela</creator><creator>Di Donato, Ferruccio</creator><creator>Santarella, Luigi</creator><creator>Bertossi, Simone</creator><creator>Cellerini, Martino</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4385-5386</orcidid></search><sort><creationdate>20201229</creationdate><title>Functional MRI (fMRI) Evaluation of Hyperbaric Oxygen Therapy (HBOT) Efficacy in Chronic Cerebral Stroke: A Small Retrospective Consecutive Case Series</title><author>Cevolani, Daniela ; Di Donato, Ferruccio ; Santarella, Luigi ; Bertossi, Simone ; Cellerini, Martino</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-815c52fbe686ef925bf6119eca2382d939522f3d736c29537b3b1bab1f7c5d633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aphasia</topic><topic>Brain Ischemia - diagnostic imaging</topic><topic>Brain Ischemia - therapy</topic><topic>Brief Report</topic><topic>Central nervous system</topic><topic>Consent</topic><topic>Dysarthria</topic><topic>Evaluation</topic><topic>Functional magnetic resonance imaging</topic><topic>Functional plasticity</topic><topic>Humans</topic><topic>Hyperbaric oxygen therapy</topic><topic>Hyperbaric Oxygenation</topic><topic>Language</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neuroplasticity</topic><topic>Outpatient care facilities</topic><topic>Oxygen therapy</topic><topic>Paresis</topic><topic>Patients</topic><topic>Resonance</topic><topic>Retrospective Studies</topic><topic>Software</topic><topic>Speech therapy</topic><topic>Stroke</topic><topic>Stroke - diagnostic imaging</topic><topic>Stroke - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cevolani, Daniela</creatorcontrib><creatorcontrib>Di Donato, Ferruccio</creatorcontrib><creatorcontrib>Santarella, Luigi</creatorcontrib><creatorcontrib>Bertossi, Simone</creatorcontrib><creatorcontrib>Cellerini, Martino</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of environmental research and public health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cevolani, Daniela</au><au>Di Donato, Ferruccio</au><au>Santarella, Luigi</au><au>Bertossi, Simone</au><au>Cellerini, Martino</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional MRI (fMRI) Evaluation of Hyperbaric Oxygen Therapy (HBOT) Efficacy in Chronic Cerebral Stroke: A Small Retrospective Consecutive Case Series</atitle><jtitle>International journal of environmental research and public health</jtitle><addtitle>Int J Environ Res Public Health</addtitle><date>2020-12-29</date><risdate>2020</risdate><volume>18</volume><issue>1</issue><spage>190</spage><pages>190-</pages><issn>1660-4601</issn><issn>1661-7827</issn><eissn>1660-4601</eissn><abstract>Functional Magnetic Resonance Imaging (fMRI) evaluation of HyberBaric Oxygen Therapy (HBOT) effects on chronic cerebral stroke Patients (Pts).
Our aim was to evaluate with fMRI, in a 3 Tesla system, the functional effects of HBOT on the Central Nervous System (CNS) in four Pts with established ischaemic and haemorrhagic cerebral strokes (2 Pts each). To our knowledge, no author used this Magnetic Resonance (MR) technique for this purpose, till now.
All four Pts underwent a fMRI study before and after 40 HBOT sessions, with a time window of a few days. They carried out two language (text listening, silent word-verb generation) and two motor (hand and foot movements) tasks (30 s On-Off block paradigms).
After HBOT, all Pts reported a clinical improvement, mostly concerning language fluency and motor paresis. fMRI analysis demonstrated an increase in both the extent and the statistical significance of most of the examined eloquent areas.
These changes were consistent with the clinical improvement in all Pts, suggesting a possible role of fMRI in revealing neuronal functional correlates of neuronal plasticity and HBOT-related neoangiogenesis. Although only four Pts were examined, fMRI proved to be a sensitive, non-invasive and reliable modality for monitoring neuronal functional changes before and after HBOT.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>33383925</pmid><doi>10.3390/ijerph18010190</doi><orcidid>https://orcid.org/0000-0003-4385-5386</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Free E-Journal (出版社公開部分のみ）; PubMed Central; Free Full-Text Journals in Chemistry; PubMed Central Open Access |
| subjects | Adult Aged Aphasia Brain Ischemia - diagnostic imaging Brain Ischemia - therapy Brief Report Central nervous system Consent Dysarthria Evaluation Functional magnetic resonance imaging Functional plasticity Humans Hyperbaric oxygen therapy Hyperbaric Oxygenation Language Magnetic Resonance Imaging Male Middle Aged Neuroplasticity Outpatient care facilities Oxygen therapy Paresis Patients Resonance Retrospective Studies Software Speech therapy Stroke Stroke - diagnostic imaging Stroke - therapy |
| title | Functional MRI (fMRI) Evaluation of Hyperbaric Oxygen Therapy (HBOT) Efficacy in Chronic Cerebral Stroke: A Small Retrospective Consecutive Case Series |
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