miR-204-3p/Nox4 Mediates Memory Deficits in a Mouse Model of Alzheimer’s Disease

Alzheimer’s disease (AD) is the most common neurodegenerative disorder leading to dementia in the elderly, and the mechanisms of AD are not fully defined. MicroRNAs (miRNAs) have been shown to contribute to memory deficits in AD. In this study, we identified that miR-204-3p was downregulated in the...

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Veröffentlicht in:	Molecular therapy 2021-01, Vol.29 (1), p.396-408
Hauptverfasser:	Tao, Wenyuan, Yu, Linjie, Shu, Shu, Liu, Ying, Zhuang, Zi, Xu, Siyi, Bao, Xinyu, Gu, Yue, Cai, Fang, Song, Weihong, Xu, Yun, Zhu, Xiaolei
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - complications Alzheimer Disease - genetics Alzheimer’s disease Amyloid beta-Peptides - metabolism Animals beta amyloid Biomarkers Disease Models, Animal Disease Susceptibility memory deficits Memory Disorders - diagnosis Memory Disorders - etiology Mice Mice, Transgenic MicroRNAs - genetics miR-204-3p NADPH Oxidase 4 - genetics Nox4 Original Oxidative Stress synaptic dysfunction
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