JNK‑IN‑8 treatment alleviates lipopolysaccharide‑induced acute lung injury via suppression of inflammation and oxidative stress regulated by JNK/NF‑κB signaling

JNK serves critical roles in numerous types of inflammation‑ and oxidative stress‑induced disease, including acute lung injury (ALI). JNK‑IN‑8 is the first irreversible JNK inhibitor that has been described. However, whether JNK‑IN‑8 can prevent lipopolysaccharide (LPS)‑induced ALI by inhibiting JNK...

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Veröffentlicht in:	Molecular medicine reports 2021-02, Vol.23 (2), Article 150
Hauptverfasser:	Du, Jingxian, Wang, Gaojian, Luo, Huanyu, Liu, Na, Xie, Junran
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdomen Acute Lung Injury - chemically induced Acute Lung Injury - metabolism Acute Lung Injury - pathology Acute Lung Injury - prevention & control Alveoli Animals Bronchus Cytokines Death & dying Euthanasia Experiments Flow cytometry IL-1β Inflammation Inflammation - chemically induced Inflammation - metabolism Inflammation - pathology Inflammation - prevention & control Interleukin 6 L-Lactate dehydrogenase Laboratory animals Lactic acid Lipopolysaccharides Lipopolysaccharides - toxicity Lung diseases Macrophages Malondialdehyde MAP Kinase Kinase 4 - antagonists & inhibitors MAP Kinase Kinase 4 - metabolism Mice Molecular modelling Neutrophils NF-kappa B - metabolism NF-κB protein Oxidative stress Oxidative Stress - drug effects Peritoneum Peroxidase Protein Kinase Inhibitors - pharmacology Reverse transcription Signal transduction Signal Transduction - drug effects Superoxide dismutase Tumor necrosis factor-α
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