Association between Maternal Adverse Childhood Experiences and Attention-Deficit/Hyperactivity Disorder in the Offspring: The Mediating Role of Antepartum Health Risks

This study aimed to examine the effect of maternal adverse childhood experiences (ACEs) on the attention-deficit/hyper-activity disorder (ADHD) symptoms in the offspring and to examine the mediating role of antepartum health risk on the intergenera-tional transmission of maternal ACEs. The participants consisted of 461 mother-child dyads. Mothers completed the ACEs questionnaire and Diagnostic Predictive Scales. Multivariate logistic regression analysis was used to estimate the risk of ADHD symptoms in the offspring of mothers with ACEs and the mediating effect of antepartum health risks by path analysis. In all, 35.4% (n=163) had at least one maternal ACE, and 11.1% (n=51) had three or more. Compared to the non-ADHD symp-tom group, the group of offspring with ADHD symptoms showed a significant association with maternal ACE score (p